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Maternal drug use and infant cleft lip/palate with special reference to corticoids

Källén, Bengt LU (2003) In The Cleft Palate-Craniofacial Journal 40(6). p.624-628
Abstract
Objective: To study the association between maternal drug use in early pregnancy and orofacial cleft in the infant. Design: Register analysis based on prospectively collected information. Patients: All delivered women in Sweden July 1, 1995, through December 31, 2001. Main outcome measure: Presence of orofacial cleft in infant. Results: Prospective information on maternal drug use during the first trimester, as reported in early pregnancy, was studied in 1142 infants with orofacial clefts, isolated or with other malformations, excluding chromosome anomalies. Any drug use was not associated with clefts (odds ratio [OR] = 0.98, 95% confidence interval [95% CI] = 0.85 to 1.13), with isolated clefts (OR = 0.92) with isolated median cleft... (More)
Objective: To study the association between maternal drug use in early pregnancy and orofacial cleft in the infant. Design: Register analysis based on prospectively collected information. Patients: All delivered women in Sweden July 1, 1995, through December 31, 2001. Main outcome measure: Presence of orofacial cleft in infant. Results: Prospective information on maternal drug use during the first trimester, as reported in early pregnancy, was studied in 1142 infants with orofacial clefts, isolated or with other malformations, excluding chromosome anomalies. Any drug use was not associated with clefts (odds ratio [OR] = 0.98, 95% confidence interval [95% CI] = 0.85 to 1.13), with isolated clefts (OR = 0.92) with isolated median cleft palate (OR = 1.03, 95% CI = 0.79 to 1.36) or with isolated cleft lip with or without cleft palate (OR = 0.86, 95% CI = 0.71 to 1.05). Reported use of multivitamins, folic acid, or 131, was not associated with a decrease in orofacial cleft risk (OR = 1.00, 95% CI = 0.63 to 1.52). ORs above 2 were seen for some drugs: sulfasalazine, naproxen, and anticonvulsants, but only a few exposed cases occurred. An association between glucocorticoid use and infant cleft was indicated and seemed to be strongest for median cleft palate. Conclusion: Maternal drug use seems to play only a small role for the origin of orofacial clefts, at least in Sweden. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
sulfasalazine, vitamins, naproxen, glucocorticoid, drugs, cleft lip, cleft palate
in
The Cleft Palate-Craniofacial Journal
volume
40
issue
6
pages
624 - 628
publisher
Allen Press
external identifiers
  • wos:000186602200011
  • pmid:14577813
  • scopus:17644448555
ISSN
1545-1569
DOI
10.1597/02-077
language
English
LU publication?
yes
id
3087eaa2-3fd4-421f-97fb-03686df15a35 (old id 295449)
date added to LUP
2007-09-13 15:25:40
date last changed
2018-06-24 03:56:10
@article{3087eaa2-3fd4-421f-97fb-03686df15a35,
  abstract     = {Objective: To study the association between maternal drug use in early pregnancy and orofacial cleft in the infant. Design: Register analysis based on prospectively collected information. Patients: All delivered women in Sweden July 1, 1995, through December 31, 2001. Main outcome measure: Presence of orofacial cleft in infant. Results: Prospective information on maternal drug use during the first trimester, as reported in early pregnancy, was studied in 1142 infants with orofacial clefts, isolated or with other malformations, excluding chromosome anomalies. Any drug use was not associated with clefts (odds ratio [OR] = 0.98, 95% confidence interval [95% CI] = 0.85 to 1.13), with isolated clefts (OR = 0.92) with isolated median cleft palate (OR = 1.03, 95% CI = 0.79 to 1.36) or with isolated cleft lip with or without cleft palate (OR = 0.86, 95% CI = 0.71 to 1.05). Reported use of multivitamins, folic acid, or 131, was not associated with a decrease in orofacial cleft risk (OR = 1.00, 95% CI = 0.63 to 1.52). ORs above 2 were seen for some drugs: sulfasalazine, naproxen, and anticonvulsants, but only a few exposed cases occurred. An association between glucocorticoid use and infant cleft was indicated and seemed to be strongest for median cleft palate. Conclusion: Maternal drug use seems to play only a small role for the origin of orofacial clefts, at least in Sweden.},
  author       = {Källén, Bengt},
  issn         = {1545-1569},
  keyword      = {sulfasalazine,vitamins,naproxen,glucocorticoid,drugs,cleft lip,cleft palate},
  language     = {eng},
  number       = {6},
  pages        = {624--628},
  publisher    = {Allen Press},
  series       = {The Cleft Palate-Craniofacial Journal},
  title        = {Maternal drug use and infant cleft lip/palate with special reference to corticoids},
  url          = {http://dx.doi.org/10.1597/02-077},
  volume       = {40},
  year         = {2003},
}