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Depletion of enteric gonadotropin-releasing hormone is found in a few patients suffering from severe gastrointestinal dysmotility.

Hammar, Oskar LU ; Ohlsson, Bodil LU ; Veress, Bela; Alm, Ragnar LU ; Nordin Fredrikson, Gunilla LU and Montgomery, Agneta LU (2012) In Scandinavian Journal of Gastroenterology 47(10). p.1165-1173
Abstract
Objective:

Many patients, especially women, suffer from severe gastrointestinal pain and dysmotility for several years without being diagnosed. Depletion of gonadotropin-releasing hormone (GnRH) in the enteric nervous system (ENS) has been described in some patients. The aim of this study was to examine the expression of GnRH in ENS and antibodies against GnRH in serum, in a dysmotility patient cohort of southern Sweden.



Materials and methods:

All consecutive patients (n = 35) referred for laparoscopic full-thickness biopsy because of symptoms or signs of severe dysmotility between 1998 and 2009, or patients with a severe dysmotility disorder having had a bowel resection within the time frame, were... (More)
Objective:

Many patients, especially women, suffer from severe gastrointestinal pain and dysmotility for several years without being diagnosed. Depletion of gonadotropin-releasing hormone (GnRH) in the enteric nervous system (ENS) has been described in some patients. The aim of this study was to examine the expression of GnRH in ENS and antibodies against GnRH in serum, in a dysmotility patient cohort of southern Sweden.



Materials and methods:

All consecutive patients (n = 35) referred for laparoscopic full-thickness biopsy because of symptoms or signs of severe dysmotility between 1998 and 2009, or patients with a severe dysmotility disorder having had a bowel resection within the time frame, were considered for inclusion. In 22 cases, representative biopsy material containing ganglia was available, and these patients were included. Medical records were scrutinized. The expression of GnRH was determined by immunohistochemistry in bowel biopsies from these patients and in patients with carcinoma or diverticulosis without ENS histopathology. Antibodies against GnRH in serum were determined by ELISA in patients and controls.



Results:

14 patients were diagnosed with enteric dysmotility (ED) and 8 with chronic intestinal pseudo-obstruction due to varying etiology. Immunostained biopsies showed expression of GnRH in the ENS. A reduced expression of GnRH-containing neurons was found in 5 patients, as well as antibodies against GnRH in serum. 3 of these patients had a history of in vitro fertilization (IVF) using GnRH analogs.



Conclusions:

A subgroup of patients with severe dysmotility had a reduced expression of GnRH-containing neurons in the ENS and expressed antibodies against GnRH in serum. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Scandinavian Journal of Gastroenterology
volume
47
issue
10
pages
1165 - 1173
publisher
Taylor & Francis
external identifiers
  • wos:000308948400005
  • pmid:22835010
  • scopus:84866599691
ISSN
1502-7708
DOI
10.3109/00365521.2012.706826
language
English
LU publication?
yes
id
7a114005-b2f6-466f-b3de-44df98d1e006 (old id 2966555)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/22835010?dopt=Abstract
date added to LUP
2012-08-10 08:50:14
date last changed
2017-08-13 03:53:11
@article{7a114005-b2f6-466f-b3de-44df98d1e006,
  abstract     = {Objective:<br/><br>
Many patients, especially women, suffer from severe gastrointestinal pain and dysmotility for several years without being diagnosed. Depletion of gonadotropin-releasing hormone (GnRH) in the enteric nervous system (ENS) has been described in some patients. The aim of this study was to examine the expression of GnRH in ENS and antibodies against GnRH in serum, in a dysmotility patient cohort of southern Sweden. <br/><br>
<br/><br>
Materials and methods:<br/><br>
All consecutive patients (n = 35) referred for laparoscopic full-thickness biopsy because of symptoms or signs of severe dysmotility between 1998 and 2009, or patients with a severe dysmotility disorder having had a bowel resection within the time frame, were considered for inclusion. In 22 cases, representative biopsy material containing ganglia was available, and these patients were included. Medical records were scrutinized. The expression of GnRH was determined by immunohistochemistry in bowel biopsies from these patients and in patients with carcinoma or diverticulosis without ENS histopathology. Antibodies against GnRH in serum were determined by ELISA in patients and controls. <br/><br>
<br/><br>
Results:<br/><br>
14 patients were diagnosed with enteric dysmotility (ED) and 8 with chronic intestinal pseudo-obstruction due to varying etiology. Immunostained biopsies showed expression of GnRH in the ENS. A reduced expression of GnRH-containing neurons was found in 5 patients, as well as antibodies against GnRH in serum. 3 of these patients had a history of in vitro fertilization (IVF) using GnRH analogs. <br/><br>
<br/><br>
Conclusions:<br/><br>
A subgroup of patients with severe dysmotility had a reduced expression of GnRH-containing neurons in the ENS and expressed antibodies against GnRH in serum.},
  author       = {Hammar, Oskar and Ohlsson, Bodil and Veress, Bela and Alm, Ragnar and Nordin Fredrikson, Gunilla and Montgomery, Agneta},
  issn         = {1502-7708},
  language     = {eng},
  number       = {10},
  pages        = {1165--1173},
  publisher    = {Taylor & Francis},
  series       = {Scandinavian Journal of Gastroenterology},
  title        = {Depletion of enteric gonadotropin-releasing hormone is found in a few patients suffering from severe gastrointestinal dysmotility.},
  url          = {http://dx.doi.org/10.3109/00365521.2012.706826},
  volume       = {47},
  year         = {2012},
}