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Role of TCF7L2 risk variant and dietary fibre intake on incident type 2 diabetes.

Hindy, George LU ; Sonestedt, Emily LU ; Ericson, Ulrika LU ; Jing, X-J; Zhou, Yuedan LU ; Hansson, Ola LU ; Renström, Erik LU ; Wirfält, Elisabet LU and Orho-Melander, Marju LU (2012) In Diabetologia 55(10). p.2646-2654
Abstract
AIMS/HYPOTHESIS:

The T allele of transcription factor 7-like 2 gene variant, TCF7L2 rs7903146, increases the risk of type 2 diabetes by 40-50%. As TCF7L2 rs7903146 has been associated with diminished incretin effect we investigated whether interaction between dietary intake of carbohydrate, fat, protein or fibre and this variant affects the risk of type 2 diabetes.



METHODS:

A cohort of 24,799 non-diabetic individuals from the Malmö Diet and Cancer Study (MDCS), with dietary data obtained by a modified diet history method, were followed up for 12 years, with 1,649 recordings of incident type 2 diabetes made. Risk of type 2 diabetes in strata of diet quintiles was analysed prospectively adjusting for... (More)
AIMS/HYPOTHESIS:

The T allele of transcription factor 7-like 2 gene variant, TCF7L2 rs7903146, increases the risk of type 2 diabetes by 40-50%. As TCF7L2 rs7903146 has been associated with diminished incretin effect we investigated whether interaction between dietary intake of carbohydrate, fat, protein or fibre and this variant affects the risk of type 2 diabetes.



METHODS:

A cohort of 24,799 non-diabetic individuals from the Malmö Diet and Cancer Study (MDCS), with dietary data obtained by a modified diet history method, were followed up for 12 years, with 1,649 recordings of incident type 2 diabetes made. Risk of type 2 diabetes in strata of diet quintiles was analysed prospectively adjusting for potential confounders. Cross-sectional analyses were performed on baseline fasting glucose and HbA(1c) levels in a subset of 5,216 randomly selected individuals from the MDCS.



RESULTS:

The elevated risk of type 2 diabetes with rs7903146 (OR 1.44, 95% CI 1.33, 1.56, p = 4.6 × 10(-19)) increased with higher intake of dietary fibre (OR 1.24, 95% CI 1.04, 1.47 to OR 1.56, 95% CI 1.31, 1.86 from the lowest to highest quintile; p (interaction) = 0.049). High intake of dietary fibre was inversely associated with diabetes incidence only among CC genotype carriers (OR 0.74, 95% CI 0.58, 0.94 per quintile, p = 0.025). The T allele was associated with 0.027% elevated HbA(1c) (p = 0.02) and this effect increased with higher intake of fibre (from -0.021% to 0.079% for the lowest to the highest quintile, p (interaction) = 0.02). Each quintile of higher fibre intake was associated with lower HbA(1c) levels among CC and CT but not among TT genotype carriers (-0.036%, p = 6.5 × 10(-7); -0.023%, p = 0.009; and 0.012%, p = 0.52, respectively).



CONCLUSIONS/INTERPRETATION:

Our study suggests that dietary fibre intake may modify the association between TCF7L2 rs7903146 and incidence of type 2 diabetes, and that higher fibre intake may associate with protection from type 2 diabetes only among non-risk allele carriers. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Diabetologia
volume
55
issue
10
pages
2646 - 2654
publisher
Springer Verlag
external identifiers
  • wos:000308354600013
  • pmid:22782288
  • scopus:84866089891
ISSN
1432-0428
DOI
10.1007/s00125-012-2634-x
language
English
LU publication?
yes
id
cf9f390d-39e2-4207-92a5-95f7fe312e60 (old id 2967274)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/22782288?dopt=Abstract
date added to LUP
2012-08-09 17:01:44
date last changed
2017-10-01 04:57:31
@article{cf9f390d-39e2-4207-92a5-95f7fe312e60,
  abstract     = {AIMS/HYPOTHESIS: <br/><br>
The T allele of transcription factor 7-like 2 gene variant, TCF7L2 rs7903146, increases the risk of type 2 diabetes by 40-50%. As TCF7L2 rs7903146 has been associated with diminished incretin effect we investigated whether interaction between dietary intake of carbohydrate, fat, protein or fibre and this variant affects the risk of type 2 diabetes. <br/><br>
<br/><br>
METHODS: <br/><br>
A cohort of 24,799 non-diabetic individuals from the Malmö Diet and Cancer Study (MDCS), with dietary data obtained by a modified diet history method, were followed up for 12 years, with 1,649 recordings of incident type 2 diabetes made. Risk of type 2 diabetes in strata of diet quintiles was analysed prospectively adjusting for potential confounders. Cross-sectional analyses were performed on baseline fasting glucose and HbA(1c) levels in a subset of 5,216 randomly selected individuals from the MDCS. <br/><br>
<br/><br>
RESULTS: <br/><br>
The elevated risk of type 2 diabetes with rs7903146 (OR 1.44, 95% CI 1.33, 1.56, p = 4.6 × 10(-19)) increased with higher intake of dietary fibre (OR 1.24, 95% CI 1.04, 1.47 to OR 1.56, 95% CI 1.31, 1.86 from the lowest to highest quintile; p (interaction) = 0.049). High intake of dietary fibre was inversely associated with diabetes incidence only among CC genotype carriers (OR 0.74, 95% CI 0.58, 0.94 per quintile, p = 0.025). The T allele was associated with 0.027% elevated HbA(1c) (p = 0.02) and this effect increased with higher intake of fibre (from -0.021% to 0.079% for the lowest to the highest quintile, p (interaction) = 0.02). Each quintile of higher fibre intake was associated with lower HbA(1c) levels among CC and CT but not among TT genotype carriers (-0.036%, p = 6.5 × 10(-7); -0.023%, p = 0.009; and 0.012%, p = 0.52, respectively). <br/><br>
<br/><br>
CONCLUSIONS/INTERPRETATION: <br/><br>
Our study suggests that dietary fibre intake may modify the association between TCF7L2 rs7903146 and incidence of type 2 diabetes, and that higher fibre intake may associate with protection from type 2 diabetes only among non-risk allele carriers.},
  author       = {Hindy, George and Sonestedt, Emily and Ericson, Ulrika and Jing, X-J and Zhou, Yuedan and Hansson, Ola and Renström, Erik and Wirfält, Elisabet and Orho-Melander, Marju},
  issn         = {1432-0428},
  language     = {eng},
  number       = {10},
  pages        = {2646--2654},
  publisher    = {Springer Verlag},
  series       = {Diabetologia},
  title        = {Role of TCF7L2 risk variant and dietary fibre intake on incident type 2 diabetes.},
  url          = {http://dx.doi.org/10.1007/s00125-012-2634-x},
  volume       = {55},
  year         = {2012},
}