Advanced

An MRI scale for assessment of haemophilic arthropathy from the International Prophylaxis Study Group.

Lundin, Björn LU ; Manco-Johnson, M L; Ignas, D M; Moineddin, R; Blanchette, V S; Dunn, A L; Gibikote, S V; Keshava, S N; Ljung, Rolf LU and Manco-Johnson, M J, et al. (2012) In Haemophilia 18(6). p.962-970
Abstract
Evaluation of prophylactic treatment of haemophilia requires sensitive methods. To design and test a new magnetic resonance imaging (MRI) scale for haemophilic arthropathy, two scales of a combined MRI scoring scheme were merged into a single scale which includes soft tissue and osteochondral subscores. Sixty-one joint MRI's of 46 patients with haemophilia were evaluated by four radiologists using the new and older scales. Forty-six of the joints were evaluated using two X-ray scales. For all MRI scores, interreader agreement and correlations with X-ray scores and lifetime number of haemarthroses were analysed. The interreader agreement intraclass correlation coefficient was 0.82, 0.89 and 0.88 for the soft tissue and osteochondral... (More)
Evaluation of prophylactic treatment of haemophilia requires sensitive methods. To design and test a new magnetic resonance imaging (MRI) scale for haemophilic arthropathy, two scales of a combined MRI scoring scheme were merged into a single scale which includes soft tissue and osteochondral subscores. Sixty-one joint MRI's of 46 patients with haemophilia were evaluated by four radiologists using the new and older scales. Forty-six of the joints were evaluated using two X-ray scales. For all MRI scores, interreader agreement and correlations with X-ray scores and lifetime number of haemarthroses were analysed. The interreader agreement intraclass correlation coefficient was 0.82, 0.89 and 0.88 for the soft tissue and osteochondral subscores and the total score, as evaluated according to the new MRI scale, compared to 0.80 and 0.89 as for the older scales. The total score and osteochondral subscore according to the new scale, as well as scores according to the older scales were correlated (P < 0.01) with number of haemarthroses (Spearman correlation 0.35-0.68) and with the X-ray scores (Spearman correlation 0.40-0.76), but no correlation (P > 0.05) was found between the soft tissue subscore of the new MRI scale and the X-ray scores. The new MRI scale is simpler to apply than the older and has similar reader reliability and correlation with lifetime number of haemarthroses, and by separating soft tissue and osteochondral changes it gives additional information. The new scale is useful for analyses of early and moderate stages of arthropathy, and may help to evaluate prophylactic haemophilia treatment. (Less)
Please use this url to cite or link to this publication:
author
, et al. (More)
(Less)
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Haemophilia
volume
18
issue
6
pages
962 - 970
publisher
Federation of European Neuroscience Societies and Blackwell Publishing Ltd
external identifiers
  • wos:000310553600034
  • pmid:22765835
  • scopus:84868204988
ISSN
1351-8216
DOI
10.1111/j.1365-2516.2012.02883.x
language
English
LU publication?
yes
id
6b10dad4-fd8d-4ae3-a3e4-6cafee4a089a (old id 2967439)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/22765835?dopt=Abstract
date added to LUP
2012-08-09 16:30:16
date last changed
2017-11-12 04:07:23
@article{6b10dad4-fd8d-4ae3-a3e4-6cafee4a089a,
  abstract     = {Evaluation of prophylactic treatment of haemophilia requires sensitive methods. To design and test a new magnetic resonance imaging (MRI) scale for haemophilic arthropathy, two scales of a combined MRI scoring scheme were merged into a single scale which includes soft tissue and osteochondral subscores. Sixty-one joint MRI's of 46 patients with haemophilia were evaluated by four radiologists using the new and older scales. Forty-six of the joints were evaluated using two X-ray scales. For all MRI scores, interreader agreement and correlations with X-ray scores and lifetime number of haemarthroses were analysed. The interreader agreement intraclass correlation coefficient was 0.82, 0.89 and 0.88 for the soft tissue and osteochondral subscores and the total score, as evaluated according to the new MRI scale, compared to 0.80 and 0.89 as for the older scales. The total score and osteochondral subscore according to the new scale, as well as scores according to the older scales were correlated (P &lt; 0.01) with number of haemarthroses (Spearman correlation 0.35-0.68) and with the X-ray scores (Spearman correlation 0.40-0.76), but no correlation (P &gt; 0.05) was found between the soft tissue subscore of the new MRI scale and the X-ray scores. The new MRI scale is simpler to apply than the older and has similar reader reliability and correlation with lifetime number of haemarthroses, and by separating soft tissue and osteochondral changes it gives additional information. The new scale is useful for analyses of early and moderate stages of arthropathy, and may help to evaluate prophylactic haemophilia treatment.},
  author       = {Lundin, Björn and Manco-Johnson, M L and Ignas, D M and Moineddin, R and Blanchette, V S and Dunn, A L and Gibikote, S V and Keshava, S N and Ljung, Rolf and Manco-Johnson, M J and Miller, S F and Rivard, G E and Doria, A S},
  issn         = {1351-8216},
  language     = {eng},
  number       = {6},
  pages        = {962--970},
  publisher    = {Federation of European Neuroscience Societies and Blackwell Publishing Ltd},
  series       = {Haemophilia},
  title        = {An MRI scale for assessment of haemophilic arthropathy from the International Prophylaxis Study Group.},
  url          = {http://dx.doi.org/10.1111/j.1365-2516.2012.02883.x},
  volume       = {18},
  year         = {2012},
}