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Association between follicle-stimulating hormone receptor polymorphisms and reproductive parameters in young men from the general population.

Lindgren, Ida LU ; Giwercman, Aleksander LU ; Axelsson, Jonatan LU and Giwercman, Yvonne LU (2012) In Pharmacogenetics & Genomics 22(9). p.667-672
Abstract
OBJECTIVE:

Follicle-stimulating hormone (FSH) regulates gametogenesis through binding to its receptor (FSHR). In women, the Thr307Ala and Asn680Ser polymorphisms in the FSHR gene affect reproductive function, but it is not clear whether they have any impact on spermatogenesis and have mainly been investigated in infertile men of varying ages. The aim of the present study was therefore to examine whether these genetic variants of the FSHR influence reproductive parameters in men from the general population.



METHODS: Men aged 17-20 years (n=313) were genotyped. All men provided a semen sample and a blood sample for hormonal measurements and DNA extraction. They underwent a medical examination and analyses of... (More)
OBJECTIVE:

Follicle-stimulating hormone (FSH) regulates gametogenesis through binding to its receptor (FSHR). In women, the Thr307Ala and Asn680Ser polymorphisms in the FSHR gene affect reproductive function, but it is not clear whether they have any impact on spermatogenesis and have mainly been investigated in infertile men of varying ages. The aim of the present study was therefore to examine whether these genetic variants of the FSHR influence reproductive parameters in men from the general population.



METHODS: Men aged 17-20 years (n=313) were genotyped. All men provided a semen sample and a blood sample for hormonal measurements and DNA extraction. They underwent a medical examination and analyses of possible associations between Thr307Ala and Asn680Ser polymorphisms and hormonal and sperm parameters were subsequently carried out.



RESULTS: Men homozygous for Thr307/Asn680 had a lower mean serum FSH concentration (3.07 vs. 3.65 IU/l, P=0.009), and higher mean serum estradiol (94.0 vs. 86.1 pmol/l, P=0.001), sex hormone-binding globulin (33.6 vs. 31.3 nmol/l, P<0.0001), and total testosterone (19.1 vs.17.9 nmol/l, P<0.0001) concentrations compared with men with other genotypes. In addition, sperm concentrations (71.9×10 vs. 70.8×10/ml, P=0.040) and the total sperm counts were higher (212×10 vs. 206×10, P<0.0001) and their testes volumes were larger (left: 11.5 vs. 11.0 ml, P<0.0001; right: 12.4 vs. 11.6 ml, P=0.002).



CONCLUSION: As in women, the results from the present study indicate that variants of the FSHR influence reproductive parameters in men. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Pharmacogenetics & Genomics
volume
22
issue
9
pages
667 - 672
publisher
Lippincott Williams & Wilkins
external identifiers
  • wos:000307652600003
  • pmid:22760496
  • scopus:84864915254
ISSN
1744-6872
DOI
10.1097/FPC.0b013e3283566c42
language
English
LU publication?
yes
id
8e628e14-dfee-40fa-bbd8-590a74c85ea7 (old id 2967503)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/22760496?dopt=Abstract
date added to LUP
2012-08-09 15:39:22
date last changed
2017-06-25 03:06:04
@article{8e628e14-dfee-40fa-bbd8-590a74c85ea7,
  abstract     = {OBJECTIVE: <br/><br>
Follicle-stimulating hormone (FSH) regulates gametogenesis through binding to its receptor (FSHR). In women, the Thr307Ala and Asn680Ser polymorphisms in the FSHR gene affect reproductive function, but it is not clear whether they have any impact on spermatogenesis and have mainly been investigated in infertile men of varying ages. The aim of the present study was therefore to examine whether these genetic variants of the FSHR influence reproductive parameters in men from the general population. <br/><br>
<br/><br>
METHODS: Men aged 17-20 years (n=313) were genotyped. All men provided a semen sample and a blood sample for hormonal measurements and DNA extraction. They underwent a medical examination and analyses of possible associations between Thr307Ala and Asn680Ser polymorphisms and hormonal and sperm parameters were subsequently carried out. <br/><br>
<br/><br>
RESULTS: Men homozygous for Thr307/Asn680 had a lower mean serum FSH concentration (3.07 vs. 3.65 IU/l, P=0.009), and higher mean serum estradiol (94.0 vs. 86.1 pmol/l, P=0.001), sex hormone-binding globulin (33.6 vs. 31.3 nmol/l, P&lt;0.0001), and total testosterone (19.1 vs.17.9 nmol/l, P&lt;0.0001) concentrations compared with men with other genotypes. In addition, sperm concentrations (71.9×10 vs. 70.8×10/ml, P=0.040) and the total sperm counts were higher (212×10 vs. 206×10, P&lt;0.0001) and their testes volumes were larger (left: 11.5 vs. 11.0 ml, P&lt;0.0001; right: 12.4 vs. 11.6 ml, P=0.002). <br/><br>
<br/><br>
CONCLUSION: As in women, the results from the present study indicate that variants of the FSHR influence reproductive parameters in men.},
  author       = {Lindgren, Ida and Giwercman, Aleksander and Axelsson, Jonatan and Giwercman, Yvonne},
  issn         = {1744-6872},
  language     = {eng},
  number       = {9},
  pages        = {667--672},
  publisher    = {Lippincott Williams & Wilkins},
  series       = {Pharmacogenetics & Genomics},
  title        = {Association between follicle-stimulating hormone receptor polymorphisms and reproductive parameters in young men from the general population.},
  url          = {http://dx.doi.org/10.1097/FPC.0b013e3283566c42},
  volume       = {22},
  year         = {2012},
}