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Staging of Lewy-related pathology in dementia

Brunnström, Hans LU ; Lindberg, Eva and Englund, Elisabet LU (2012) In Clinical Neuropathology 31(4). p.216-223
Abstract
Objective: Lewy-related pathology is the characteristic feature of Parkinson's disease with and without dementia and dementia with Lewy bodies (DLB). There are two neuropathological staging systems for Lewy-related pathology commonly employed today: the staging system for Parkinson-related pathology by Braak et al., and the staging system by the Consortium on DLB. There are also several modified systems based on these two scales. Methods: We applied a total of eight different staging systems for Lewy-related pathology to 36 consecutive demented patients with various dementia disorders. Results: The staging systems varied considerably in number of unclassifiable cases (range 0 - 16 out of 36 cases), while the diagnostic agreement between... (More)
Objective: Lewy-related pathology is the characteristic feature of Parkinson's disease with and without dementia and dementia with Lewy bodies (DLB). There are two neuropathological staging systems for Lewy-related pathology commonly employed today: the staging system for Parkinson-related pathology by Braak et al., and the staging system by the Consortium on DLB. There are also several modified systems based on these two scales. Methods: We applied a total of eight different staging systems for Lewy-related pathology to 36 consecutive demented patients with various dementia disorders. Results: The staging systems varied considerably in number of unclassifiable cases (range 0 - 16 out of 36 cases), while the diagnostic agreement between the systems that were able to classify all or the very majority of cases varied only slightly (weighted kappa 0.86 - 0.92 and Spearman's sigma 0.80 - 1.0). Conclusion: The different staging systems for Lewy-related pathology that exist today vary in staging procedure and proportion of unclassifiable cases. The choice of system may affect the stage of Lewy-related pathology and ultimately final diagnosis. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Lewy body, Lewy body disease, neuropathology, Parkinson's disease
in
Clinical Neuropathology
volume
31
issue
4
pages
216 - 223
publisher
Dustri-Verlag
external identifiers
  • wos:000306575700004
  • scopus:84864122260
ISSN
0722-5091
DOI
10.5414/NP300471
language
English
LU publication?
yes
id
ba599498-6fcd-4d97-a084-623deaa55457 (old id 2979341)
date added to LUP
2012-09-03 07:15:55
date last changed
2017-01-01 06:01:33
@article{ba599498-6fcd-4d97-a084-623deaa55457,
  abstract     = {Objective: Lewy-related pathology is the characteristic feature of Parkinson's disease with and without dementia and dementia with Lewy bodies (DLB). There are two neuropathological staging systems for Lewy-related pathology commonly employed today: the staging system for Parkinson-related pathology by Braak et al., and the staging system by the Consortium on DLB. There are also several modified systems based on these two scales. Methods: We applied a total of eight different staging systems for Lewy-related pathology to 36 consecutive demented patients with various dementia disorders. Results: The staging systems varied considerably in number of unclassifiable cases (range 0 - 16 out of 36 cases), while the diagnostic agreement between the systems that were able to classify all or the very majority of cases varied only slightly (weighted kappa 0.86 - 0.92 and Spearman's sigma 0.80 - 1.0). Conclusion: The different staging systems for Lewy-related pathology that exist today vary in staging procedure and proportion of unclassifiable cases. The choice of system may affect the stage of Lewy-related pathology and ultimately final diagnosis.},
  author       = {Brunnström, Hans and Lindberg, Eva and Englund, Elisabet},
  issn         = {0722-5091},
  keyword      = {Lewy body,Lewy body disease,neuropathology,Parkinson's disease},
  language     = {eng},
  number       = {4},
  pages        = {216--223},
  publisher    = {Dustri-Verlag},
  series       = {Clinical Neuropathology},
  title        = {Staging of Lewy-related pathology in dementia},
  url          = {http://dx.doi.org/10.5414/NP300471},
  volume       = {31},
  year         = {2012},
}