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Preventing Parastomal Hernia After Ileal Conduit by the Use of a Prophylactic Mesh : A Randomised Study

Liedberg, Fredrik LU ; Kollberg, Petter LU ; Allerbo, Marie ; Baseckas, Gediminas ; Brändstedt, Johan LU ; Gudjonsson, Sigurdur LU ; Hagberg, Oskar LU ; Håkansson, Ulf LU ; Jerlström, Tomas and Löfgren, Annica LU , et al. (2020) In European Urology 78(5). p.757-763
Abstract

Background: Parastomal hernia (PSH) after urinary diversion with ileal conduit is frequently a clinical problem. Objective: To investigate whether a prophylactic lightweight mesh in the sublay position can reduce the cumulative incidence of PSH after open cystectomy with ileal conduit. Design, setting, and participants: From 2012 to 2017, we randomised 242 patients 1:1 to conventional stoma construction (n = 124) or prophylactic mesh (n = 118) at three Swedish hospitals (ISRCTN 95093825). Outcome measurements and statistical analysis: The primary endpoint was clinical PSH, and secondary endpoints were radiological PSH assessed in prone position with the stoma in the centre of a ring, parastomal bulging, and complications from the mesh.... (More)

Background: Parastomal hernia (PSH) after urinary diversion with ileal conduit is frequently a clinical problem. Objective: To investigate whether a prophylactic lightweight mesh in the sublay position can reduce the cumulative incidence of PSH after open cystectomy with ileal conduit. Design, setting, and participants: From 2012 to 2017, we randomised 242 patients 1:1 to conventional stoma construction (n = 124) or prophylactic mesh (n = 118) at three Swedish hospitals (ISRCTN 95093825). Outcome measurements and statistical analysis: The primary endpoint was clinical PSH, and secondary endpoints were radiological PSH assessed in prone position with the stoma in the centre of a ring, parastomal bulging, and complications from the mesh. Results and limitations: Within 24 mo, 20/89 (23%) patients in the control arm and 10/92 (11%) in the intervention arm had developed a clinical PSH (p = 0.06) after a median follow-up of 3 yr, corresponding to a hazard ratio of 0.45 (confidence interval 0.24–0.86, p = 0.02) in the intervention arm. The proportions of radiological PSHs within 24 mo were 22/89 (25%) and 17/92 (19%) in the two study arms. During follow-up, five patients in the control arm and two in the intervention arm were operated for PSH. The median operating time was 50 min longer in patients receiving a mesh. No differences were noted in proportions of Clavien-Dindo complications at 90 d postoperatively or in complications related to the mesh during follow-up. Conclusions: Prophylactic implantation of a lightweight mesh in the sublay position decreases the risk of PSH when constructing an ileal conduit without increasing the risk of complications related to the mesh. The median surgical time is prolonged by mesh implantation. Patient summary: In this randomised report, we looked at the risk of parastomal hernia after cystectomy and urinary diversion with ileal conduit with or without the use of a prophylactic mesh. We conclude that such a prophylactic measure decreased the occurrence of parastomal hernias, with only a slight increase in operating time and no added risk of complications related to the mesh.

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Contribution to journal
publication status
published
subject
keywords
Bladder cancer, Cystectomy, Ileal conduit, Parastomal hernia, Prophylactic mesh
in
European Urology
volume
78
issue
5
pages
7 pages
publisher
Elsevier
external identifiers
  • pmid:32800407
  • scopus:85089355855
ISSN
0302-2838
DOI
10.1016/j.eururo.2020.07.033
language
English
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yes
id
29adaee7-6001-4a67-bb27-2453c8f771c0
date added to LUP
2020-08-24 08:18:14
date last changed
2021-04-11 04:52:56
@article{29adaee7-6001-4a67-bb27-2453c8f771c0,
  abstract     = {<p>Background: Parastomal hernia (PSH) after urinary diversion with ileal conduit is frequently a clinical problem. Objective: To investigate whether a prophylactic lightweight mesh in the sublay position can reduce the cumulative incidence of PSH after open cystectomy with ileal conduit. Design, setting, and participants: From 2012 to 2017, we randomised 242 patients 1:1 to conventional stoma construction (n = 124) or prophylactic mesh (n = 118) at three Swedish hospitals (ISRCTN 95093825). Outcome measurements and statistical analysis: The primary endpoint was clinical PSH, and secondary endpoints were radiological PSH assessed in prone position with the stoma in the centre of a ring, parastomal bulging, and complications from the mesh. Results and limitations: Within 24 mo, 20/89 (23%) patients in the control arm and 10/92 (11%) in the intervention arm had developed a clinical PSH (p = 0.06) after a median follow-up of 3 yr, corresponding to a hazard ratio of 0.45 (confidence interval 0.24–0.86, p = 0.02) in the intervention arm. The proportions of radiological PSHs within 24 mo were 22/89 (25%) and 17/92 (19%) in the two study arms. During follow-up, five patients in the control arm and two in the intervention arm were operated for PSH. The median operating time was 50 min longer in patients receiving a mesh. No differences were noted in proportions of Clavien-Dindo complications at 90 d postoperatively or in complications related to the mesh during follow-up. Conclusions: Prophylactic implantation of a lightweight mesh in the sublay position decreases the risk of PSH when constructing an ileal conduit without increasing the risk of complications related to the mesh. The median surgical time is prolonged by mesh implantation. Patient summary: In this randomised report, we looked at the risk of parastomal hernia after cystectomy and urinary diversion with ileal conduit with or without the use of a prophylactic mesh. We conclude that such a prophylactic measure decreased the occurrence of parastomal hernias, with only a slight increase in operating time and no added risk of complications related to the mesh.</p>},
  author       = {Liedberg, Fredrik and Kollberg, Petter and Allerbo, Marie and Baseckas, Gediminas and Brändstedt, Johan and Gudjonsson, Sigurdur and Hagberg, Oskar and Håkansson, Ulf and Jerlström, Tomas and Löfgren, Annica and Patschan, Oliver and Sörenby, Anne and Bläckberg, Mats},
  issn         = {0302-2838},
  language     = {eng},
  number       = {5},
  pages        = {757--763},
  publisher    = {Elsevier},
  series       = {European Urology},
  title        = {Preventing Parastomal Hernia After Ileal Conduit by the Use of a Prophylactic Mesh : A Randomised Study},
  url          = {http://dx.doi.org/10.1016/j.eururo.2020.07.033},
  doi          = {10.1016/j.eururo.2020.07.033},
  volume       = {78},
  year         = {2020},
}