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In-vitro digestion of curcumin loaded chitosan-coated liposomes

Cuomo, Francesca; Cofelice, Martina; Venditti, Francesco; Ceglie, Andrea; Miguel, Maria LU ; Lindman, Björn LU and Lopez, Francesco (2017) In Colloids and Surfaces B: Biointerfaces
Abstract

Liposomes are considered a major route for encapsulation of hydrophilic and hydrophobic molecules. Chitosan coated liposomes could represent an alternative way as a carrier for delivery of drugs in human body. In this study the preparation and applicability of chitosan-coated liposomes containing curcumin as well as curcumin loaded anionic liposomes were evaluated. The applicability of the carriers was tested by means of an in-vitro digestion procedure allowing for measurement of the bioaccessibility of ingested curcumin. Values of diameter, polydispersity index and surface charge for curcumin loaded anionic liposomes obtained through dynamic light scattering and ζ-potential measurements were 129. nm, 0.095 and -49. mV, respectively.... (More)

Liposomes are considered a major route for encapsulation of hydrophilic and hydrophobic molecules. Chitosan coated liposomes could represent an alternative way as a carrier for delivery of drugs in human body. In this study the preparation and applicability of chitosan-coated liposomes containing curcumin as well as curcumin loaded anionic liposomes were evaluated. The applicability of the carriers was tested by means of an in-vitro digestion procedure allowing for measurement of the bioaccessibility of ingested curcumin. Values of diameter, polydispersity index and surface charge for curcumin loaded anionic liposomes obtained through dynamic light scattering and ζ-potential measurements were 129. nm, 0.095 and -49. mV, respectively. After chitosan-coating, diameter and polydispersity index remain unvaried while the surface charge gets positive.Slightly higher curcumin concentrations were found after the mouth and the stomach digestion phases when curcumin was loaded in anionic liposomes. On the contrary, after the intestinal phase, a higher percentage of curcumin was found when chitosan-coated liposomes were used as carrier, both in the raw digesta and in the bile salt micellar phase. It was shown that the presence of a positively charged surface allows a better absorption of curcumin in the small intestine phase, which increases the overall curcumin bioavailability. The mechanism behind these results can be understood from the composition of the different environments generated by the digestive fluids that differently interact with anionic or cationic surfaces.

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Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
epub
subject
keywords
Bioavailability, Chitosan, Coated-liposomes, Curcumin, Digestion phase
in
Colloids and Surfaces B: Biointerfaces
publisher
Elsevier
external identifiers
  • scopus:85034837484
ISSN
0927-7765
DOI
10.1016/j.colsurfb.2017.11.047
language
English
LU publication?
yes
id
29d58fda-ad59-42d4-b32b-c786a4ca1c96
date added to LUP
2017-12-11 12:50:10
date last changed
2018-01-07 12:28:07
@article{29d58fda-ad59-42d4-b32b-c786a4ca1c96,
  abstract     = {<p>Liposomes are considered a major route for encapsulation of hydrophilic and hydrophobic molecules. Chitosan coated liposomes could represent an alternative way as a carrier for delivery of drugs in human body. In this study the preparation and applicability of chitosan-coated liposomes containing curcumin as well as curcumin loaded anionic liposomes were evaluated. The applicability of the carriers was tested by means of an in-vitro digestion procedure allowing for measurement of the bioaccessibility of ingested curcumin. Values of diameter, polydispersity index and surface charge for curcumin loaded anionic liposomes obtained through dynamic light scattering and ζ-potential measurements were 129. nm, 0.095 and -49. mV, respectively. After chitosan-coating, diameter and polydispersity index remain unvaried while the surface charge gets positive.Slightly higher curcumin concentrations were found after the mouth and the stomach digestion phases when curcumin was loaded in anionic liposomes. On the contrary, after the intestinal phase, a higher percentage of curcumin was found when chitosan-coated liposomes were used as carrier, both in the raw digesta and in the bile salt micellar phase. It was shown that the presence of a positively charged surface allows a better absorption of curcumin in the small intestine phase, which increases the overall curcumin bioavailability. The mechanism behind these results can be understood from the composition of the different environments generated by the digestive fluids that differently interact with anionic or cationic surfaces.</p>},
  author       = {Cuomo, Francesca and Cofelice, Martina and Venditti, Francesco and Ceglie, Andrea and Miguel, Maria and Lindman, Björn and Lopez, Francesco},
  issn         = {0927-7765},
  keyword      = {Bioavailability,Chitosan,Coated-liposomes,Curcumin,Digestion phase},
  language     = {eng},
  month        = {11},
  publisher    = {Elsevier},
  series       = {Colloids and Surfaces B: Biointerfaces},
  title        = {In-vitro digestion of curcumin loaded chitosan-coated liposomes},
  url          = {http://dx.doi.org/10.1016/j.colsurfb.2017.11.047},
  year         = {2017},
}