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Stability analysis of an artificial biomolecular oscillator with non-cooperative regulatory interactions

Cuba Samaniego, Christian; Giordano, Giulia LU ; Blanchini, Franco and Franco, Elisa (2017) In Journal of Biological Dynamics 11(1). p.102-120
Abstract
Oscillators are essential to fuel autonomous behaviours in molecular systems. Artificial oscillators built with programmable biological molecules such as DNA and RNA are generally easy to build and tune, and can serve as timers for biological computation and regulation. We describe a new artificial nucleic acid biochemical reaction network, and we demonstrate its capacity to exhibit oscillatory solutions. This network can be built in vitro using nucleic acids and three bacteriophage enzymes, and has the potential to be implemented in cells. Numerical simulations suggest that oscillations occur in a realistic range of reaction rates and concentrations.
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Biological Dynamics
volume
11
issue
1
pages
19 pages
publisher
Taylor & Francis
external identifiers
  • scopus:84995957112
  • wos:000389042600002
ISSN
1751-3766
DOI
10.1080/17513758.2016.1245790
language
English
LU publication?
yes
id
29f14cae-527b-4ccf-b174-a720d3c8f1aa
alternative location
http://dx.doi.org/10.1080/17513758.2016.1245790
date added to LUP
2016-11-26 15:00:30
date last changed
2018-07-08 04:19:20
@article{29f14cae-527b-4ccf-b174-a720d3c8f1aa,
  abstract     = {Oscillators are essential to fuel autonomous behaviours in molecular systems. Artificial oscillators built with programmable biological molecules such as DNA and RNA are generally easy to build and tune, and can serve as timers for biological computation and regulation. We describe a new artificial nucleic acid biochemical reaction network, and we demonstrate its capacity to exhibit oscillatory solutions. This network can be built in vitro using nucleic acids and three bacteriophage enzymes, and has the potential to be implemented in cells. Numerical simulations suggest that oscillations occur in a realistic range of reaction rates and concentrations.},
  author       = {Cuba Samaniego, Christian and Giordano, Giulia and Blanchini, Franco and Franco, Elisa},
  issn         = {1751-3766},
  language     = {eng},
  number       = {1},
  pages        = {102--120},
  publisher    = {Taylor & Francis},
  series       = {Journal of Biological Dynamics},
  title        = {Stability analysis of an artificial biomolecular oscillator with non-cooperative regulatory interactions},
  url          = {http://dx.doi.org/10.1080/17513758.2016.1245790},
  volume       = {11},
  year         = {2017},
}