High hyperdiploid childhood acute lymphoblastic leukemia : Chromosomal gains as the main driver event
(2016) In Molecular and Cellular Oncology 3(1).- Abstract
High hyperdiploid childhood acute lymphoblastic leukemia is characterized by multiple chromosomal gains. Recent results show that this subtype harbors relatively few genetic abnormalities besides the extra chromosomes, which appear to arise early and are likely the main driver event. Secondary hits primarily target genes in the rat sarcoma (RAS) signaling pathway and histone modifiers.
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https://lup.lub.lu.se/record/2a32328c-fb10-4b46-a5a5-c3dd2c76f33b
- author
- Paulsson, Kajsa LU
- organization
- publishing date
- 2016-01-02
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Acute lymphoblastic leukemia, aneuploidy, chromosome, hyperdiploidy, mutation
- in
- Molecular and Cellular Oncology
- volume
- 3
- issue
- 1
- article number
- e1064555
- publisher
- Taylor & Francis
- external identifiers
-
- scopus:85050771745
- ISSN
- 2372-3556
- DOI
- 10.1080/23723556.2015.1064555
- language
- English
- LU publication?
- yes
- id
- 2a32328c-fb10-4b46-a5a5-c3dd2c76f33b
- date added to LUP
- 2018-08-28 12:32:31
- date last changed
- 2022-04-25 08:50:29
@article{2a32328c-fb10-4b46-a5a5-c3dd2c76f33b, abstract = {{<p>High hyperdiploid childhood acute lymphoblastic leukemia is characterized by multiple chromosomal gains. Recent results show that this subtype harbors relatively few genetic abnormalities besides the extra chromosomes, which appear to arise early and are likely the main driver event. Secondary hits primarily target genes in the rat sarcoma (RAS) signaling pathway and histone modifiers.</p>}}, author = {{Paulsson, Kajsa}}, issn = {{2372-3556}}, keywords = {{Acute lymphoblastic leukemia; aneuploidy; chromosome; hyperdiploidy; mutation}}, language = {{eng}}, month = {{01}}, number = {{1}}, publisher = {{Taylor & Francis}}, series = {{Molecular and Cellular Oncology}}, title = {{High hyperdiploid childhood acute lymphoblastic leukemia : Chromosomal gains as the main driver event}}, url = {{http://dx.doi.org/10.1080/23723556.2015.1064555}}, doi = {{10.1080/23723556.2015.1064555}}, volume = {{3}}, year = {{2016}}, }