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High hyperdiploid childhood acute lymphoblastic leukemia : Chromosomal gains as the main driver event

Paulsson, Kajsa LU (2016) In Molecular and Cellular Oncology 3(1).
Abstract

High hyperdiploid childhood acute lymphoblastic leukemia is characterized by multiple chromosomal gains. Recent results show that this subtype harbors relatively few genetic abnormalities besides the extra chromosomes, which appear to arise early and are likely the main driver event. Secondary hits primarily target genes in the rat sarcoma (RAS) signaling pathway and histone modifiers.

Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Acute lymphoblastic leukemia, aneuploidy, chromosome, hyperdiploidy, mutation
in
Molecular and Cellular Oncology
volume
3
issue
1
article number
e1064555
publisher
Taylor & Francis
external identifiers
  • scopus:85050771745
ISSN
2372-3556
DOI
10.1080/23723556.2015.1064555
language
English
LU publication?
yes
id
2a32328c-fb10-4b46-a5a5-c3dd2c76f33b
date added to LUP
2018-08-28 12:32:31
date last changed
2022-04-25 08:50:29
@article{2a32328c-fb10-4b46-a5a5-c3dd2c76f33b,
  abstract     = {{<p>High hyperdiploid childhood acute lymphoblastic leukemia is characterized by multiple chromosomal gains. Recent results show that this subtype harbors relatively few genetic abnormalities besides the extra chromosomes, which appear to arise early and are likely the main driver event. Secondary hits primarily target genes in the rat sarcoma (RAS) signaling pathway and histone modifiers.</p>}},
  author       = {{Paulsson, Kajsa}},
  issn         = {{2372-3556}},
  keywords     = {{Acute lymphoblastic leukemia; aneuploidy; chromosome; hyperdiploidy; mutation}},
  language     = {{eng}},
  month        = {{01}},
  number       = {{1}},
  publisher    = {{Taylor & Francis}},
  series       = {{Molecular and Cellular Oncology}},
  title        = {{High hyperdiploid childhood acute lymphoblastic leukemia : Chromosomal gains as the main driver event}},
  url          = {{http://dx.doi.org/10.1080/23723556.2015.1064555}},
  doi          = {{10.1080/23723556.2015.1064555}},
  volume       = {{3}},
  year         = {{2016}},
}