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SDHB and CDK1 protein expression in metastatic pheochromocytoma and paraganglioma

Gunnesson, Lisa ; Karakaya, Sinan LU ; Mohlin, Sofie LU orcid ; Muth, Andreas and Elias, Erik (2026) In Endocrine Oncology 6(1).
Abstract

BACKGROUND: Pheochromocytomas and paragangliomas (PPGLs) are rare and mostly non-metastatic tumors originating from adrenal medulla and paraganglia. Metastatic PGLs have a worse prognosis, but currently, there are no established criteria to determine PPGL metastatic potential.

AIM: The aim of this study was to investigate whether SDHB and CDK1 expression is associated with metastatic capacity in PPGL.

MATERIAL AND METHODS: A tissue microarray (TMA) was constructed from 175 tumors from a total of 149 unique PPGL patients treated at Sahlgrenska University Hospital. SDHB, CDK1, and proliferation index Ki-67 were assessed and correlated to metastatic capacity defined as a confirmed metastatic event.

RESULTS: Negative SDHB... (More)

BACKGROUND: Pheochromocytomas and paragangliomas (PPGLs) are rare and mostly non-metastatic tumors originating from adrenal medulla and paraganglia. Metastatic PGLs have a worse prognosis, but currently, there are no established criteria to determine PPGL metastatic potential.

AIM: The aim of this study was to investigate whether SDHB and CDK1 expression is associated with metastatic capacity in PPGL.

MATERIAL AND METHODS: A tissue microarray (TMA) was constructed from 175 tumors from a total of 149 unique PPGL patients treated at Sahlgrenska University Hospital. SDHB, CDK1, and proliferation index Ki-67 were assessed and correlated to metastatic capacity defined as a confirmed metastatic event.

RESULTS: Negative SDHB expression was more common in patients with metastatic PPGL and displayed a trend toward lower overall survival and correlation with higher Ki-67%. High CDK1 expression was not associated with any of the parameters mentioned above.

CONCLUSION: Negative SDHB expression but not high CDK1 expression is associated with metastatic capacity in PPGL.

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author
; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Endocrine Oncology
volume
6
issue
1
article number
e260035
publisher
BioScientifica
external identifiers
  • pmid:42656897
ISSN
2634-4793
DOI
10.1530/EO-26-0035
language
English
LU publication?
yes
additional info
© the author(s).
id
2a4c3ce5-2450-4c06-8cf0-05918e023851
date added to LUP
2026-08-31 15:16:31
date last changed
2026-08-31 15:20:24
@article{2a4c3ce5-2450-4c06-8cf0-05918e023851,
  abstract     = {{<p>BACKGROUND: Pheochromocytomas and paragangliomas (PPGLs) are rare and mostly non-metastatic tumors originating from adrenal medulla and paraganglia. Metastatic PGLs have a worse prognosis, but currently, there are no established criteria to determine PPGL metastatic potential.</p><p>AIM: The aim of this study was to investigate whether SDHB and CDK1 expression is associated with metastatic capacity in PPGL.</p><p>MATERIAL AND METHODS: A tissue microarray (TMA) was constructed from 175 tumors from a total of 149 unique PPGL patients treated at Sahlgrenska University Hospital. SDHB, CDK1, and proliferation index Ki-67 were assessed and correlated to metastatic capacity defined as a confirmed metastatic event.</p><p>RESULTS: Negative SDHB expression was more common in patients with metastatic PPGL and displayed a trend toward lower overall survival and correlation with higher Ki-67%. High CDK1 expression was not associated with any of the parameters mentioned above.</p><p>CONCLUSION: Negative SDHB expression but not high CDK1 expression is associated with metastatic capacity in PPGL.</p>}},
  author       = {{Gunnesson, Lisa and Karakaya, Sinan and Mohlin, Sofie and Muth, Andreas and Elias, Erik}},
  issn         = {{2634-4793}},
  language     = {{eng}},
  number       = {{1}},
  publisher    = {{BioScientifica}},
  series       = {{Endocrine Oncology}},
  title        = {{SDHB and CDK1 protein expression in metastatic pheochromocytoma and paraganglioma}},
  url          = {{http://dx.doi.org/10.1530/EO-26-0035}},
  doi          = {{10.1530/EO-26-0035}},
  volume       = {{6}},
  year         = {{2026}},
}