Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

Neurogenesis in stroke and epilepsy

Kokaia, Zaal LU orcid ; Arvidsson, Andreas LU ; Ekdahl Clementson, Christine LU and Lindvall, Olle LU (2004) 12th Colloque on Medicine and Research in Neurosciences p.139-146
Abstract
Ischemic and epileptic insults promote neurogenesis from neural stem cells located in the dentate subgranular zone and in the subventricular zone lining the lateral ventricles. These findings raise the possibility that the adult brain tries to use its own stem cells to repair itself. New neurons generated by ischemic insults have now been shown to migrate from the subventricular zone and posterior periventricle to the damaged striatum and CA1 region, respectively. Here they express morphological markers characteristic of those neurons that have died, and some evidence indicates that these neurons can re-establish connections. However, we still lack much information about the regulation of insult-induced neurogenesis and its behavioral... (More)
Ischemic and epileptic insults promote neurogenesis from neural stem cells located in the dentate subgranular zone and in the subventricular zone lining the lateral ventricles. These findings raise the possibility that the adult brain tries to use its own stem cells to repair itself. New neurons generated by ischemic insults have now been shown to migrate from the subventricular zone and posterior periventricle to the damaged striatum and CA1 region, respectively. Here they express morphological markers characteristic of those neurons that have died, and some evidence indicates that these neurons can re-establish connections. However, we still lack much information about the regulation of insult-induced neurogenesis and its behavioral consequences. The new neurons may contribute to functional recovery but have also been suggested to be involved. in the development of epilepsy. (Less)
Please use this url to cite or link to this publication:
author
; ; and
organization
publishing date
type
Chapter in Book/Report/Conference proceeding
publication status
published
subject
host publication
Stem Cells in the Nervous System: Functional and Clinical Implications (Research and Perspectives in Neurosciences)
pages
139 - 146
publisher
Springer
conference name
12th Colloque on Medicine and Research in Neurosciences
conference location
Paris, France
conference dates
2003-01-20
external identifiers
  • wos:000189504400010
ISSN
0945-6082
ISBN
978-3-540-20558-6
language
English
LU publication?
yes
additional info
The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Restorative Neurology (0131000160)
id
2a6d30d3-1e9a-4577-8e7b-422b12089a4d (old id 1406683)
date added to LUP
2016-04-01 16:50:06
date last changed
2018-11-21 20:44:34
@inproceedings{2a6d30d3-1e9a-4577-8e7b-422b12089a4d,
  abstract     = {{Ischemic and epileptic insults promote neurogenesis from neural stem cells located in the dentate subgranular zone and in the subventricular zone lining the lateral ventricles. These findings raise the possibility that the adult brain tries to use its own stem cells to repair itself. New neurons generated by ischemic insults have now been shown to migrate from the subventricular zone and posterior periventricle to the damaged striatum and CA1 region, respectively. Here they express morphological markers characteristic of those neurons that have died, and some evidence indicates that these neurons can re-establish connections. However, we still lack much information about the regulation of insult-induced neurogenesis and its behavioral consequences. The new neurons may contribute to functional recovery but have also been suggested to be involved. in the development of epilepsy.}},
  author       = {{Kokaia, Zaal and Arvidsson, Andreas and Ekdahl Clementson, Christine and Lindvall, Olle}},
  booktitle    = {{Stem Cells in the Nervous System: Functional and Clinical Implications (Research and Perspectives in Neurosciences)}},
  isbn         = {{978-3-540-20558-6}},
  issn         = {{0945-6082}},
  language     = {{eng}},
  pages        = {{139--146}},
  publisher    = {{Springer}},
  title        = {{Neurogenesis in stroke and epilepsy}},
  year         = {{2004}},
}