Regional differences in the incidence of lymphocytic and collagenous colitis over time
Larsson, Johanna Kristina LU ; Clarkson, Spencer and Sjoberg, Klas LU
(2023)
In Scandinavian Journal of Gastroenterology
58(12).
p.1445-1452
- Abstract
Background: In microscopic colitis (MC), the incidence has increased over the last decades. The aim of the present study was to determine the incidence of lymphocytic (LC) and collagenous colitis (CC) in the county Skåne (Scania), southern Sweden, during the period 2010–20 with focus both on the temporal and spatial variations. Methods: The MC diagnosis was retrieved from the biopsy registries at the Departments of Pathology. Established diagnostic criteria (increased lymphocyte count, inflammation in lamina propria and in CC a collagen band) were used for diagnosis. Age, gender, date for diagnosis and municipality of residence were retrieved for all patients. Results: In total 1985 patients could be identified with a mean age of 62.9... (More)
Background: In microscopic colitis (MC), the incidence has increased over the last decades. The aim of the present study was to determine the incidence of lymphocytic (LC) and collagenous colitis (CC) in the county Skåne (Scania), southern Sweden, during the period 2010–20 with focus both on the temporal and spatial variations. Methods: The MC diagnosis was retrieved from the biopsy registries at the Departments of Pathology. Established diagnostic criteria (increased lymphocyte count, inflammation in lamina propria and in CC a collagen band) were used for diagnosis. Age, gender, date for diagnosis and municipality of residence were retrieved for all patients. Results: In total 1985 patients could be identified with a mean age of 62.9 years (SD 15.7) whereof 1415 were women. The incidence for CC was stable with a total age-standardized rate (ASR) per 100 000 person-years of 6.34, (range 4.6–8.1). In LC the ASR was 7.90 (range 1.7–15.2) but increased markedly 2015–20 reaching 15.2 in 2019. Also, the northwest part of the region showed significantly higher ASR:s of LC during the last part of the decade in comparation to the whole region. Conclusions: The incidence of CC was stable during the period while LC differed substantially in a way that indicates that it most probably must be two different disease entities. In LC, in view of the marked and rapid increase, although no definitive explanation could be found, causative environmental factors could be contemplated, why further studies are indicated.
(Less)
- author
- Larsson, Johanna Kristina
LU
; Clarkson, Spencer
and Sjoberg, Klas
LU
- organization
- publishing date
- 2023
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Collagenous colitis, epidemiology, incidence, lymphocytic colitis, microscopic colitis, skåne
- in
- Scandinavian Journal of Gastroenterology
- volume
- 58
- issue
- 12
- pages
- 1445 - 1452
- publisher
- Taylor & Francis
- external identifiers
-
- pmid:37599473
- scopus:85168485184
- ISSN
- 0036-5521
- DOI
- 10.1080/00365521.2023.2248536
- language
- English
- LU publication?
- yes
- id
- 2aaa613c-4d87-42d1-87ce-eea040a5728a
- date added to LUP
- 2023-11-13 14:49:48
- date last changed
- 2024-04-25 06:06:02
@article{2aaa613c-4d87-42d1-87ce-eea040a5728a,
abstract = {{<p>Background: In microscopic colitis (MC), the incidence has increased over the last decades. The aim of the present study was to determine the incidence of lymphocytic (LC) and collagenous colitis (CC) in the county Skåne (Scania), southern Sweden, during the period 2010–20 with focus both on the temporal and spatial variations. Methods: The MC diagnosis was retrieved from the biopsy registries at the Departments of Pathology. Established diagnostic criteria (increased lymphocyte count, inflammation in lamina propria and in CC a collagen band) were used for diagnosis. Age, gender, date for diagnosis and municipality of residence were retrieved for all patients. Results: In total 1985 patients could be identified with a mean age of 62.9 years (SD 15.7) whereof 1415 were women. The incidence for CC was stable with a total age-standardized rate (ASR) per 100 000 person-years of 6.34, (range 4.6–8.1). In LC the ASR was 7.90 (range 1.7–15.2) but increased markedly 2015–20 reaching 15.2 in 2019. Also, the northwest part of the region showed significantly higher ASR:s of LC during the last part of the decade in comparation to the whole region. Conclusions: The incidence of CC was stable during the period while LC differed substantially in a way that indicates that it most probably must be two different disease entities. In LC, in view of the marked and rapid increase, although no definitive explanation could be found, causative environmental factors could be contemplated, why further studies are indicated.</p>}},
author = {{Larsson, Johanna Kristina and Clarkson, Spencer and Sjoberg, Klas}},
issn = {{0036-5521}},
keywords = {{Collagenous colitis; epidemiology; incidence; lymphocytic colitis; microscopic colitis; skåne}},
language = {{eng}},
number = {{12}},
pages = {{1445--1452}},
publisher = {{Taylor & Francis}},
series = {{Scandinavian Journal of Gastroenterology}},
title = {{Regional differences in the incidence of lymphocytic and collagenous colitis over time}},
url = {{http://dx.doi.org/10.1080/00365521.2023.2248536}},
doi = {{10.1080/00365521.2023.2248536}},
volume = {{58}},
year = {{2023}},
}