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Insulin-like growth factor II plays a central role in atherosclerosis in a mouse model.

Zaina, Silvio LU ; Pettersson, Linda ; Ahrén, Bo LU ; Brånén, Lena LU ; Hassan, A Bassim ; Lindholm, Marie LU ; Mattsson, Ragnar ; Thyberg, Johan and Nilsson, Jan LU (2002) In Journal of Biological Chemistry 277(6). p.4505-4511
Abstract
Insulin-like growth factor II is a fetal promoter of cell proliferation that is involved in some forms of cancer and overgrowth syndromes in humans. Here, we provide two sources of genetic evidence for a novel, pivotal role of locally produced insulin-like growth factor II in the development of atherosclerosis. First, we show that homozygosity for a disrupted insulin-like growth factor II allele in mice lacking apolipoprotein E, a widely used animal model of atherosclerosis, results in aortic lesions that are approximately 80% smaller and contain approximately 50% less proliferating cells compared with mice lacking only apolipoprotein E. Second, targeted expression of an insulin-like growth factor II transgene in smooth muscle cells, but... (More)
Insulin-like growth factor II is a fetal promoter of cell proliferation that is involved in some forms of cancer and overgrowth syndromes in humans. Here, we provide two sources of genetic evidence for a novel, pivotal role of locally produced insulin-like growth factor II in the development of atherosclerosis. First, we show that homozygosity for a disrupted insulin-like growth factor II allele in mice lacking apolipoprotein E, a widely used animal model of atherosclerosis, results in aortic lesions that are approximately 80% smaller and contain approximately 50% less proliferating cells compared with mice lacking only apolipoprotein E. Second, targeted expression of an insulin-like growth factor II transgene in smooth muscle cells, but not the mere elevation of circulating levels of the peptide, causes per se aortic focal intimal thickenings. The insulin-like growth factor II transgenics presented here are the first viable mutant mice spontaneously developing intimal masses. These observations provide the first direct evidence for an atherogenic activity of insulin-like growth factor II in vivo. (Less)
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author
; ; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Animal, Pathology, Ultrastructure, Arteriosclerosis, Disease Models, Transgenes, Aorta
in
Journal of Biological Chemistry
volume
277
issue
6
pages
4505 - 4511
publisher
American Society for Biochemistry and Molecular Biology
external identifiers
  • wos:000173813900093
  • pmid:11726660
  • scopus:0037040247
ISSN
1083-351X
DOI
10.1074/jbc.M108061200
language
English
LU publication?
yes
id
2ab13cba-2b44-4f20-9b7c-bc6d382b29b6 (old id 107055)
alternative location
http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11726660&dopt=Abstract
date added to LUP
2016-04-01 11:41:57
date last changed
2024-01-07 17:07:22
@article{2ab13cba-2b44-4f20-9b7c-bc6d382b29b6,
  abstract     = {{Insulin-like growth factor II is a fetal promoter of cell proliferation that is involved in some forms of cancer and overgrowth syndromes in humans. Here, we provide two sources of genetic evidence for a novel, pivotal role of locally produced insulin-like growth factor II in the development of atherosclerosis. First, we show that homozygosity for a disrupted insulin-like growth factor II allele in mice lacking apolipoprotein E, a widely used animal model of atherosclerosis, results in aortic lesions that are approximately 80% smaller and contain approximately 50% less proliferating cells compared with mice lacking only apolipoprotein E. Second, targeted expression of an insulin-like growth factor II transgene in smooth muscle cells, but not the mere elevation of circulating levels of the peptide, causes per se aortic focal intimal thickenings. The insulin-like growth factor II transgenics presented here are the first viable mutant mice spontaneously developing intimal masses. These observations provide the first direct evidence for an atherogenic activity of insulin-like growth factor II in vivo.}},
  author       = {{Zaina, Silvio and Pettersson, Linda and Ahrén, Bo and Brånén, Lena and Hassan, A Bassim and Lindholm, Marie and Mattsson, Ragnar and Thyberg, Johan and Nilsson, Jan}},
  issn         = {{1083-351X}},
  keywords     = {{Animal; Pathology; Ultrastructure; Arteriosclerosis; Disease Models; Transgenes; Aorta}},
  language     = {{eng}},
  number       = {{6}},
  pages        = {{4505--4511}},
  publisher    = {{American Society for Biochemistry and Molecular Biology}},
  series       = {{Journal of Biological Chemistry}},
  title        = {{Insulin-like growth factor II plays a central role in atherosclerosis in a mouse model.}},
  url          = {{http://dx.doi.org/10.1074/jbc.M108061200}},
  doi          = {{10.1074/jbc.M108061200}},
  volume       = {{277}},
  year         = {{2002}},
}