Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

MicroRNA-155 and Anti-Müllerian Hormone : New Potential Markers of Subfertility in Men with Chronic Kidney Disease

Eckersten, Dag LU ; Tsatsanis, Christos LU ; Giwercman, Aleksander LU ; Bruun, Laila LU ; Pihlsgård, Mats LU and Christensson, Anders LU (2017) In Nephron Extra 7(1). p.33-41
Abstract

Background/Aims: Men with terminal renal failure are often infertile. Anti-müllerian hormone (AMH), a marker of Sertoli cell function, is decreased among men with chronic kidney disease (CKD). Recently, a microRNA, miR-155, has been shown to be a potential marker for subfertility. We studied miR-155 and semen parameters in patients with CKD who were not yet on dialysis. We also aimed to study possible associations between AMH, miR-155, and semen parameters to evaluate them as markers of fertility. Methods: Thirty male patients with CKD 1–4 as well as 18 healthy controls were enrolled. Results: Serum levels of miR-155 were significantly higher among men with CKD stages 1–2 (4.51 ± 3.81 [p = 0.01]) and stages 3–4 (2.75 ± 1.77 [p = 0.006])... (More)

Background/Aims: Men with terminal renal failure are often infertile. Anti-müllerian hormone (AMH), a marker of Sertoli cell function, is decreased among men with chronic kidney disease (CKD). Recently, a microRNA, miR-155, has been shown to be a potential marker for subfertility. We studied miR-155 and semen parameters in patients with CKD who were not yet on dialysis. We also aimed to study possible associations between AMH, miR-155, and semen parameters to evaluate them as markers of fertility. Methods: Thirty male patients with CKD 1–4 as well as 18 healthy controls were enrolled. Results: Serum levels of miR-155 were significantly higher among men with CKD stages 1–2 (4.51 ± 3.81 [p = 0.01]) and stages 3–4 (2.75 ± 1.77 [p = 0.006]) than in controls (1.09 ± 0.44). Sperm concentration was significantly lower among men with CKD 3–4 (42 ± 29) ×106/mL compared to controls (88 ± 42) ×106/mL (p = 0.011). High levels of miR-155 were associated with a relatively low sperm concentration (p = 0.02) and with a low total sperm number (p = 0.005). Low AMH levels were associated with a decreased percentage of motile sperm cells (p = 0.02). Conclusions: We conclude that men with stage 3–4 CKD had lower sperm concentrations than healthy fertile men and that increased serum miR-155 in men with stage 1–4 CKD was associated with semen parameters that indicate subfertility. Low AMH levels were associated with a low percentage of the total number of motile sperm cells. miR-155 and AMH may be potential markers of subfertility in men with CKD.

(Less)
Please use this url to cite or link to this publication:
author
; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Chronic kidney disease, Fertility, Hemodialysis
in
Nephron Extra
volume
7
issue
1
pages
33 - 41
publisher
Karger
external identifiers
  • scopus:85018469129
  • pmid:28553316
  • wos:000410092600002
ISSN
1664-5529
DOI
10.1159/000458711
language
English
LU publication?
yes
id
2ab3d1e0-3680-456c-912c-95a6e239d0dc
date added to LUP
2017-05-23 15:31:27
date last changed
2024-02-29 15:25:07
@article{2ab3d1e0-3680-456c-912c-95a6e239d0dc,
  abstract     = {{<p>Background/Aims: Men with terminal renal failure are often infertile. Anti-müllerian hormone (AMH), a marker of Sertoli cell function, is decreased among men with chronic kidney disease (CKD). Recently, a microRNA, miR-155, has been shown to be a potential marker for subfertility. We studied miR-155 and semen parameters in patients with CKD who were not yet on dialysis. We also aimed to study possible associations between AMH, miR-155, and semen parameters to evaluate them as markers of fertility. Methods: Thirty male patients with CKD 1–4 as well as 18 healthy controls were enrolled. Results: Serum levels of miR-155 were significantly higher among men with CKD stages 1–2 (4.51 ± 3.81 [p = 0.01]) and stages 3–4 (2.75 ± 1.77 [p = 0.006]) than in controls (1.09 ± 0.44). Sperm concentration was significantly lower among men with CKD 3–4 (42 ± 29) ×10<sup>6</sup>/mL compared to controls (88 ± 42) ×10<sup>6</sup>/mL (p = 0.011). High levels of miR-155 were associated with a relatively low sperm concentration (p = 0.02) and with a low total sperm number (p = 0.005). Low AMH levels were associated with a decreased percentage of motile sperm cells (p = 0.02). Conclusions: We conclude that men with stage 3–4 CKD had lower sperm concentrations than healthy fertile men and that increased serum miR-155 in men with stage 1–4 CKD was associated with semen parameters that indicate subfertility. Low AMH levels were associated with a low percentage of the total number of motile sperm cells. miR-155 and AMH may be potential markers of subfertility in men with CKD.</p>}},
  author       = {{Eckersten, Dag and Tsatsanis, Christos and Giwercman, Aleksander and Bruun, Laila and Pihlsgård, Mats and Christensson, Anders}},
  issn         = {{1664-5529}},
  keywords     = {{Chronic kidney disease; Fertility; Hemodialysis}},
  language     = {{eng}},
  month        = {{04}},
  number       = {{1}},
  pages        = {{33--41}},
  publisher    = {{Karger}},
  series       = {{Nephron Extra}},
  title        = {{MicroRNA-155 and Anti-Müllerian Hormone : New Potential Markers of Subfertility in Men with Chronic Kidney Disease}},
  url          = {{http://dx.doi.org/10.1159/000458711}},
  doi          = {{10.1159/000458711}},
  volume       = {{7}},
  year         = {{2017}},
}