MicroRNA-155 and Anti-Müllerian Hormone : New Potential Markers of Subfertility in Men with Chronic Kidney Disease
(2017) In Nephron Extra 7(1). p.33-41- Abstract
Background/Aims: Men with terminal renal failure are often infertile. Anti-müllerian hormone (AMH), a marker of Sertoli cell function, is decreased among men with chronic kidney disease (CKD). Recently, a microRNA, miR-155, has been shown to be a potential marker for subfertility. We studied miR-155 and semen parameters in patients with CKD who were not yet on dialysis. We also aimed to study possible associations between AMH, miR-155, and semen parameters to evaluate them as markers of fertility. Methods: Thirty male patients with CKD 1–4 as well as 18 healthy controls were enrolled. Results: Serum levels of miR-155 were significantly higher among men with CKD stages 1–2 (4.51 ± 3.81 [p = 0.01]) and stages 3–4 (2.75 ± 1.77 [p = 0.006])... (More)
Background/Aims: Men with terminal renal failure are often infertile. Anti-müllerian hormone (AMH), a marker of Sertoli cell function, is decreased among men with chronic kidney disease (CKD). Recently, a microRNA, miR-155, has been shown to be a potential marker for subfertility. We studied miR-155 and semen parameters in patients with CKD who were not yet on dialysis. We also aimed to study possible associations between AMH, miR-155, and semen parameters to evaluate them as markers of fertility. Methods: Thirty male patients with CKD 1–4 as well as 18 healthy controls were enrolled. Results: Serum levels of miR-155 were significantly higher among men with CKD stages 1–2 (4.51 ± 3.81 [p = 0.01]) and stages 3–4 (2.75 ± 1.77 [p = 0.006]) than in controls (1.09 ± 0.44). Sperm concentration was significantly lower among men with CKD 3–4 (42 ± 29) ×106/mL compared to controls (88 ± 42) ×106/mL (p = 0.011). High levels of miR-155 were associated with a relatively low sperm concentration (p = 0.02) and with a low total sperm number (p = 0.005). Low AMH levels were associated with a decreased percentage of motile sperm cells (p = 0.02). Conclusions: We conclude that men with stage 3–4 CKD had lower sperm concentrations than healthy fertile men and that increased serum miR-155 in men with stage 1–4 CKD was associated with semen parameters that indicate subfertility. Low AMH levels were associated with a low percentage of the total number of motile sperm cells. miR-155 and AMH may be potential markers of subfertility in men with CKD.
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- author
- Eckersten, Dag LU ; Tsatsanis, Christos LU ; Giwercman, Aleksander LU ; Bruun, Laila LU ; Pihlsgård, Mats LU and Christensson, Anders LU
- organization
- publishing date
- 2017-04-07
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Chronic kidney disease, Fertility, Hemodialysis
- in
- Nephron Extra
- volume
- 7
- issue
- 1
- pages
- 33 - 41
- publisher
- Karger
- external identifiers
-
- scopus:85018469129
- pmid:28553316
- wos:000410092600002
- ISSN
- 1664-5529
- DOI
- 10.1159/000458711
- language
- English
- LU publication?
- yes
- id
- 2ab3d1e0-3680-456c-912c-95a6e239d0dc
- date added to LUP
- 2017-05-23 15:31:27
- date last changed
- 2025-01-07 14:02:22
@article{2ab3d1e0-3680-456c-912c-95a6e239d0dc, abstract = {{<p>Background/Aims: Men with terminal renal failure are often infertile. Anti-müllerian hormone (AMH), a marker of Sertoli cell function, is decreased among men with chronic kidney disease (CKD). Recently, a microRNA, miR-155, has been shown to be a potential marker for subfertility. We studied miR-155 and semen parameters in patients with CKD who were not yet on dialysis. We also aimed to study possible associations between AMH, miR-155, and semen parameters to evaluate them as markers of fertility. Methods: Thirty male patients with CKD 1–4 as well as 18 healthy controls were enrolled. Results: Serum levels of miR-155 were significantly higher among men with CKD stages 1–2 (4.51 ± 3.81 [p = 0.01]) and stages 3–4 (2.75 ± 1.77 [p = 0.006]) than in controls (1.09 ± 0.44). Sperm concentration was significantly lower among men with CKD 3–4 (42 ± 29) ×10<sup>6</sup>/mL compared to controls (88 ± 42) ×10<sup>6</sup>/mL (p = 0.011). High levels of miR-155 were associated with a relatively low sperm concentration (p = 0.02) and with a low total sperm number (p = 0.005). Low AMH levels were associated with a decreased percentage of motile sperm cells (p = 0.02). Conclusions: We conclude that men with stage 3–4 CKD had lower sperm concentrations than healthy fertile men and that increased serum miR-155 in men with stage 1–4 CKD was associated with semen parameters that indicate subfertility. Low AMH levels were associated with a low percentage of the total number of motile sperm cells. miR-155 and AMH may be potential markers of subfertility in men with CKD.</p>}}, author = {{Eckersten, Dag and Tsatsanis, Christos and Giwercman, Aleksander and Bruun, Laila and Pihlsgård, Mats and Christensson, Anders}}, issn = {{1664-5529}}, keywords = {{Chronic kidney disease; Fertility; Hemodialysis}}, language = {{eng}}, month = {{04}}, number = {{1}}, pages = {{33--41}}, publisher = {{Karger}}, series = {{Nephron Extra}}, title = {{MicroRNA-155 and Anti-Müllerian Hormone : New Potential Markers of Subfertility in Men with Chronic Kidney Disease}}, url = {{http://dx.doi.org/10.1159/000458711}}, doi = {{10.1159/000458711}}, volume = {{7}}, year = {{2017}}, }