Inherited genetic susceptibility to multiple myeloma
(2014) In Leukemia 28(3). p.518-524- Abstract
- Although the familial clustering of multiple myeloma (MM) supports the role of inherited susceptibility, only recently has direct evidence for genetic predisposition been demonstrated. A meta-analysis of two genome-wide association (GWA) studies has identified single-nucleotide polymorphisms (SNPs) localising to a number of genomic regions that are robustly associated with MM risk. In this review, we provide an overview of the evidence supporting a genetic contribution to the predisposition to MM and MGUS (monoclonal gammopathy of unknown significance), and the insight this gives into the biological basis of disease aetiology. We also highlight the promise of future approaches to identify further specific risk factors and their potential... (More)
- Although the familial clustering of multiple myeloma (MM) supports the role of inherited susceptibility, only recently has direct evidence for genetic predisposition been demonstrated. A meta-analysis of two genome-wide association (GWA) studies has identified single-nucleotide polymorphisms (SNPs) localising to a number of genomic regions that are robustly associated with MM risk. In this review, we provide an overview of the evidence supporting a genetic contribution to the predisposition to MM and MGUS (monoclonal gammopathy of unknown significance), and the insight this gives into the biological basis of disease aetiology. We also highlight the promise of future approaches to identify further specific risk factors and their potential clinical utility. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/4410642
- author
- Morgan, G. J. ; Johnson, D. C. ; Weinhold, N. ; Goldschmidt, H. ; Landgren, O. ; Lynch, H. T. ; Hemminki, Kari LU and Houlston, R. S.
- organization
- publishing date
- 2014
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- myeloma, SNP, MGUS
- in
- Leukemia
- volume
- 28
- issue
- 3
- pages
- 518 - 524
- publisher
- Nature Publishing Group
- external identifiers
-
- wos:000332845700005
- scopus:84895802141
- pmid:24247655
- ISSN
- 1476-5551
- DOI
- 10.1038/leu.2013.344
- language
- English
- LU publication?
- yes
- id
- 2ab5b02b-8b9f-47e2-b020-206b6ff17eec (old id 4410642)
- date added to LUP
- 2016-04-01 14:44:53
- date last changed
- 2022-04-22 05:02:42
@article{2ab5b02b-8b9f-47e2-b020-206b6ff17eec, abstract = {{Although the familial clustering of multiple myeloma (MM) supports the role of inherited susceptibility, only recently has direct evidence for genetic predisposition been demonstrated. A meta-analysis of two genome-wide association (GWA) studies has identified single-nucleotide polymorphisms (SNPs) localising to a number of genomic regions that are robustly associated with MM risk. In this review, we provide an overview of the evidence supporting a genetic contribution to the predisposition to MM and MGUS (monoclonal gammopathy of unknown significance), and the insight this gives into the biological basis of disease aetiology. We also highlight the promise of future approaches to identify further specific risk factors and their potential clinical utility.}}, author = {{Morgan, G. J. and Johnson, D. C. and Weinhold, N. and Goldschmidt, H. and Landgren, O. and Lynch, H. T. and Hemminki, Kari and Houlston, R. S.}}, issn = {{1476-5551}}, keywords = {{myeloma; SNP; MGUS}}, language = {{eng}}, number = {{3}}, pages = {{518--524}}, publisher = {{Nature Publishing Group}}, series = {{Leukemia}}, title = {{Inherited genetic susceptibility to multiple myeloma}}, url = {{http://dx.doi.org/10.1038/leu.2013.344}}, doi = {{10.1038/leu.2013.344}}, volume = {{28}}, year = {{2014}}, }