Long-term mortality rate in rheumatoid arthritis patients with disease onset in the 1980s.
C Kapetanovic, Meliha LU ; Lindqvist, Elisabet LU
; Geborek, Pierre
LU
; Saxne, Tore
LU
and Eberhardt, Kerstin
LU
(2011)
In Scandinavian Journal of Rheumatology
40.
p.433-438
- Abstract
- Objective: To investigate the mortality rate and possible early predictive factors of mortality after 19-23 years in a cohort of patients with rheumatoid arthritis (RA) followed prospectively from disease onset. Patients and methods: A community-based cohort of 183 patients (63% female) with RA and disease duration < 2 years was recruited 1985-1989. The patients were followed yearly from diagnosis until death or 31 December 2008. Mean age and mean duration of symptoms (range) at diagnosis were 52 (18-78) years and 11 (0-24) months, respectively. Death certificates were obtained from the Swedish Cause of Death Register and causes of death were coded by the International Classification of Diseases (ICD-10). Death rates of RA patients were... (More)
- Objective: To investigate the mortality rate and possible early predictive factors of mortality after 19-23 years in a cohort of patients with rheumatoid arthritis (RA) followed prospectively from disease onset. Patients and methods: A community-based cohort of 183 patients (63% female) with RA and disease duration < 2 years was recruited 1985-1989. The patients were followed yearly from diagnosis until death or 31 December 2008. Mean age and mean duration of symptoms (range) at diagnosis were 52 (18-78) years and 11 (0-24) months, respectively. Death certificates were obtained from the Swedish Cause of Death Register and causes of death were coded by the International Classification of Diseases (ICD-10). Death rates of RA patients were compared to those of age- and sex-matched controls. Possible predictors of mortality were analysed using a Cox regression model. Results: By 31 December 2008, 69 patients (37 women and 32 men) had died. The standardized mortality ratio (SMR) was 1.23 [95% confidence interval (CI) 0.97-1.55] and p < 0.09. Older age, male sex, smoking, and the presence of cardiovascular disease (CVD) at RA diagnosis were identified as early predictors of mortality. CVD was the most common cause of death (46%), followed by malignancies (29%) and infections (13%). RA was not stated as the direct cause of death in any patient and was mentioned among underlying causes in only 16/69 (23%) patients. Conclusion: Mortality rate after 19-23 years of disease duration in this cohort of patients with disease onset in the 1980s was not significantly increased compared to age- and sex-matched controls. No RA disease-related factor predicted mortality. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1972011
- author
- C Kapetanovic, Meliha
LU
; Lindqvist, Elisabet
LU
; Geborek, Pierre
LU
; Saxne, Tore
LU
and Eberhardt, Kerstin
LU
- organization
- publishing date
- 2011
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Scandinavian Journal of Rheumatology
- volume
- 40
- pages
- 433 - 438
- publisher
- Taylor & Francis
- external identifiers
-
- wos:000297852500004
- pmid:21619489
- scopus:83455259449
- pmid:21619489
- ISSN
- 1502-7732
- DOI
- 10.3109/03009742.2011.573503
- language
- English
- LU publication?
- yes
- id
- 2abe37c7-fd2d-4817-bdd7-9e5bb526d992 (old id 1972011)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/21619489?dopt=Abstract
- date added to LUP
- 2016-04-01 10:00:21
- date last changed
- 2022-01-25 18:49:20
@article{2abe37c7-fd2d-4817-bdd7-9e5bb526d992,
abstract = {{Objective: To investigate the mortality rate and possible early predictive factors of mortality after 19-23 years in a cohort of patients with rheumatoid arthritis (RA) followed prospectively from disease onset. Patients and methods: A community-based cohort of 183 patients (63% female) with RA and disease duration < 2 years was recruited 1985-1989. The patients were followed yearly from diagnosis until death or 31 December 2008. Mean age and mean duration of symptoms (range) at diagnosis were 52 (18-78) years and 11 (0-24) months, respectively. Death certificates were obtained from the Swedish Cause of Death Register and causes of death were coded by the International Classification of Diseases (ICD-10). Death rates of RA patients were compared to those of age- and sex-matched controls. Possible predictors of mortality were analysed using a Cox regression model. Results: By 31 December 2008, 69 patients (37 women and 32 men) had died. The standardized mortality ratio (SMR) was 1.23 [95% confidence interval (CI) 0.97-1.55] and p < 0.09. Older age, male sex, smoking, and the presence of cardiovascular disease (CVD) at RA diagnosis were identified as early predictors of mortality. CVD was the most common cause of death (46%), followed by malignancies (29%) and infections (13%). RA was not stated as the direct cause of death in any patient and was mentioned among underlying causes in only 16/69 (23%) patients. Conclusion: Mortality rate after 19-23 years of disease duration in this cohort of patients with disease onset in the 1980s was not significantly increased compared to age- and sex-matched controls. No RA disease-related factor predicted mortality.}},
author = {{C Kapetanovic, Meliha and Lindqvist, Elisabet and Geborek, Pierre and Saxne, Tore and Eberhardt, Kerstin}},
issn = {{1502-7732}},
language = {{eng}},
pages = {{433--438}},
publisher = {{Taylor & Francis}},
series = {{Scandinavian Journal of Rheumatology}},
title = {{Long-term mortality rate in rheumatoid arthritis patients with disease onset in the 1980s.}},
url = {{https://lup.lub.lu.se/search/files/1474155/1979611.pdf}},
doi = {{10.3109/03009742.2011.573503}},
volume = {{40}},
year = {{2011}},
}