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Nuclear medicine : Physics and instrumentation special feature review article: SPECT/CT: An update on technological developments and clinical applications

Ljungberg, Michael LU and Pretorius, P. Hendrik (2018) In British Journal of Radiology 91(1081).
Abstract

Functional nuclear medicine imaging with single-photon emission CT (SPECT) in combination with anatomical CT has been commercially available since the beginning of this century. The combination of the two modalities has improved both the sensitivity and specificity of many clinical applications and CT in conjunction with SPECT that allows for spatial overlay of the SPECT data on good anatomy images. Introduction of diagnostic CT units as part of the SPECT/CT system has also potentially allowed for a more cost-efficient use of the equipment. Most of the SPECT systems available are based on the well-known Anger camera principle with Nal(TI) as a scintillation material, parallel-hole collimators and multiple photomultiplier tubes, which,... (More)

Functional nuclear medicine imaging with single-photon emission CT (SPECT) in combination with anatomical CT has been commercially available since the beginning of this century. The combination of the two modalities has improved both the sensitivity and specificity of many clinical applications and CT in conjunction with SPECT that allows for spatial overlay of the SPECT data on good anatomy images. Introduction of diagnostic CT units as part of the SPECT/CT system has also potentially allowed for a more cost-efficient use of the equipment. Most of the SPECT systems available are based on the well-known Anger camera principle with Nal(TI) as a scintillation material, parallel-hole collimators and multiple photomultiplier tubes, which, from the centroid of the scintillation light, determine the position of an event. Recently, solid-state detectors using cadmium-zinc-Telluride became available and clinical SPECT cameras employing multiple pinhole collimators have been developed and introduced in the market. However, even if new systems become available with better hardware, the SPECT reconstruction will still be affected by photon attenuation and scatter and collimator response. Compensation for these effects is needed even for qualitative studies to avoid artefacts leading to false positives. This review highlights ):he recent progress for both new SPECT cameras systems as well as for various data-processing and compensation methods.

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published
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in
British Journal of Radiology
volume
91
issue
1081
publisher
British Inst Radiology
external identifiers
  • scopus:85039041206
ISSN
0007-1285
DOI
language
English
LU publication?
yes
id
2b1de984-bfc7-4994-aa95-ec3e16490db6
date added to LUP
2018-01-24 14:06:59
date last changed
2018-06-17 05:30:09
@article{2b1de984-bfc7-4994-aa95-ec3e16490db6,
  abstract     = {<p>Functional nuclear medicine imaging with single-photon emission CT (SPECT) in combination with anatomical CT has been commercially available since the beginning of this century. The combination of the two modalities has improved both the sensitivity and specificity of many clinical applications and CT in conjunction with SPECT that allows for spatial overlay of the SPECT data on good anatomy images. Introduction of diagnostic CT units as part of the SPECT/CT system has also potentially allowed for a more cost-efficient use of the equipment. Most of the SPECT systems available are based on the well-known Anger camera principle with Nal(TI) as a scintillation material, parallel-hole collimators and multiple photomultiplier tubes, which, from the centroid of the scintillation light, determine the position of an event. Recently, solid-state detectors using cadmium-zinc-Telluride became available and clinical SPECT cameras employing multiple pinhole collimators have been developed and introduced in the market. However, even if new systems become available with better hardware, the SPECT reconstruction will still be affected by photon attenuation and scatter and collimator response. Compensation for these effects is needed even for qualitative studies to avoid artefacts leading to false positives. This review highlights ):he recent progress for both new SPECT cameras systems as well as for various data-processing and compensation methods.</p>},
  articleno    = {20160402},
  author       = {Ljungberg, Michael and Pretorius, P. Hendrik},
  issn         = {0007-1285},
  language     = {eng},
  number       = {1081},
  publisher    = {British Inst Radiology},
  series       = {British Journal of Radiology},
  title        = {Nuclear medicine : Physics and instrumentation special feature review article: SPECT/CT: An update on technological developments and clinical applications},
  url          = {http://dx.doi.org/},
  volume       = {91},
  year         = {2018},
}