Advanced

Protein kinase C inhibition has only a transient growth arresting effect on in vitro regenerating mouse sensory neurons

Wiklund, Peter LU and Ekström, Per LU (1999) In Neuroscience Letters 275(3). p.155-158
Abstract

Adult mice sensory ganglia were cultured in an extracellular matrix gel. Analyses of extending axons were made 48 h (long-term) or immediately (short-term) after addition of protein kinase inhibitors. Long- and short-term growth was insensitive to protein kinase A/G inhibition by HA-1004. Long-term protein kinase C inhibition by chelerythrine affected only certain, long axons. In the short-term virtually all axon growth was arrested, but largely recovered on the following day. When combined, the drugs inhibited all long- and short-term growth and largely prevented the recovery of the latter. The transient effect by chelerythrine, and the permanent inhibition after combination with HA-1004, suggests compensatory mechanisms, perhaps via... (More)

Adult mice sensory ganglia were cultured in an extracellular matrix gel. Analyses of extending axons were made 48 h (long-term) or immediately (short-term) after addition of protein kinase inhibitors. Long- and short-term growth was insensitive to protein kinase A/G inhibition by HA-1004. Long-term protein kinase C inhibition by chelerythrine affected only certain, long axons. In the short-term virtually all axon growth was arrested, but largely recovered on the following day. When combined, the drugs inhibited all long- and short-term growth and largely prevented the recovery of the latter. The transient effect by chelerythrine, and the permanent inhibition after combination with HA-1004, suggests compensatory mechanisms, perhaps via other kinases. Copyright (C) 1999 Elsevier Science Ireland Ltd.

(Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Chelerythrine chloride, Dorsal root ganglia, Growth cones, HA-1004, Protein kinase A, Protein kinase G
in
Neuroscience Letters
volume
275
issue
3
pages
4 pages
publisher
Elsevier
external identifiers
  • scopus:0032754898
ISSN
0304-3940
DOI
10.1016/S0304-3940(99)00720-X
language
English
LU publication?
yes
id
2b7fb55c-0453-40ae-8739-43a5a2b5bc2f
date added to LUP
2016-12-07 14:47:27
date last changed
2017-04-28 13:35:51
@article{2b7fb55c-0453-40ae-8739-43a5a2b5bc2f,
  abstract     = {<p>Adult mice sensory ganglia were cultured in an extracellular matrix gel. Analyses of extending axons were made 48 h (long-term) or immediately (short-term) after addition of protein kinase inhibitors. Long- and short-term growth was insensitive to protein kinase A/G inhibition by HA-1004. Long-term protein kinase C inhibition by chelerythrine affected only certain, long axons. In the short-term virtually all axon growth was arrested, but largely recovered on the following day. When combined, the drugs inhibited all long- and short-term growth and largely prevented the recovery of the latter. The transient effect by chelerythrine, and the permanent inhibition after combination with HA-1004, suggests compensatory mechanisms, perhaps via other kinases. Copyright (C) 1999 Elsevier Science Ireland Ltd.</p>},
  author       = {Wiklund, Peter and Ekström, Per},
  issn         = {0304-3940},
  keyword      = {Chelerythrine chloride,Dorsal root ganglia,Growth cones,HA-1004,Protein kinase A,Protein kinase G},
  language     = {eng},
  month        = {11},
  number       = {3},
  pages        = {155--158},
  publisher    = {Elsevier},
  series       = {Neuroscience Letters},
  title        = {Protein kinase C inhibition has only a transient growth arresting effect on in vitro regenerating mouse sensory neurons},
  url          = {http://dx.doi.org/10.1016/S0304-3940(99)00720-X},
  volume       = {275},
  year         = {1999},
}