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Symptoms and syndromes associated with SARS-CoV-2 infection and severity in pregnant women from two community cohorts

Molteni, Erika ; Astley, Christina M. ; Ma, Wenjie ; Sudre, Carole H. ; Magee, Laura A. ; Murray, Benjamin ; Fall, Tove LU ; Gomez, Maria F. LU ; Tsereteli, Neli LU and Franks, Paul W. LU , et al. (2021) In Scientific Reports 11(1).
Abstract

We tested whether pregnant and non-pregnant women differ in COVID-19 symptom profile and severity, and we extended previous investigations on hospitalized pregnant women to those who did not require hospitalization. Two female community-based cohorts (18–44 years) provided longitudinal (smartphone application, N = 1,170,315, n = 79 pregnant tested positive) and cross-sectional (web-based survey, N = 1,344,966, n = 134 pregnant tested positive) data, prospectively collected through self-participatory citizen surveillance in UK, Sweden and USA. Pregnant and non-pregnant were compared for frequencies of events, including SARS-CoV-2 testing, symptoms and hospitalization rates. Multivariable regression was used to investigate symptoms... (More)

We tested whether pregnant and non-pregnant women differ in COVID-19 symptom profile and severity, and we extended previous investigations on hospitalized pregnant women to those who did not require hospitalization. Two female community-based cohorts (18–44 years) provided longitudinal (smartphone application, N = 1,170,315, n = 79 pregnant tested positive) and cross-sectional (web-based survey, N = 1,344,966, n = 134 pregnant tested positive) data, prospectively collected through self-participatory citizen surveillance in UK, Sweden and USA. Pregnant and non-pregnant were compared for frequencies of events, including SARS-CoV-2 testing, symptoms and hospitalization rates. Multivariable regression was used to investigate symptoms severity and comorbidity effects. Pregnant and non-pregnant women positive for SARS-CoV-2 infection were not different in syndromic severity, except for gastrointestinal symptoms. Pregnant were more likely to have received testing, despite reporting fewer symptoms. Pre-existing lung disease was most closely associated with syndromic severity in pregnant hospitalized. Heart and kidney diseases and diabetes increased risk. The most frequent symptoms among non-hospitalized women were anosmia [63% pregnant, 92% non-pregnant] and headache [72%, 62%]. Cardiopulmonary symptoms, including persistent cough [80%] and chest pain [73%], were more frequent among pregnant who were hospitalized. Consistent with observations in non-pregnant populations, lung disease and diabetes were associated with increased risk of more severe SARS-CoV-2 infection during pregnancy.

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type
Contribution to journal
publication status
published
subject
in
Scientific Reports
volume
11
issue
1
article number
6928
publisher
Nature Publishing Group
external identifiers
  • pmid:33767292
  • scopus:85103518443
ISSN
2045-2322
DOI
10.1038/s41598-021-86452-3
language
English
LU publication?
yes
id
2c0487e4-51e5-4477-b3c5-2b2ee0d30960
date added to LUP
2021-04-12 08:28:04
date last changed
2021-04-27 04:34:01
@article{2c0487e4-51e5-4477-b3c5-2b2ee0d30960,
  abstract     = {<p>We tested whether pregnant and non-pregnant women differ in COVID-19 symptom profile and severity, and we extended previous investigations on hospitalized pregnant women to those who did not require hospitalization. Two female community-based cohorts (18–44 years) provided longitudinal (smartphone application, N = 1,170,315, n = 79 pregnant tested positive) and cross-sectional (web-based survey, N = 1,344,966, n = 134 pregnant tested positive) data, prospectively collected through self-participatory citizen surveillance in UK, Sweden and USA. Pregnant and non-pregnant were compared for frequencies of events, including SARS-CoV-2 testing, symptoms and hospitalization rates. Multivariable regression was used to investigate symptoms severity and comorbidity effects. Pregnant and non-pregnant women positive for SARS-CoV-2 infection were not different in syndromic severity, except for gastrointestinal symptoms. Pregnant were more likely to have received testing, despite reporting fewer symptoms. Pre-existing lung disease was most closely associated with syndromic severity in pregnant hospitalized. Heart and kidney diseases and diabetes increased risk. The most frequent symptoms among non-hospitalized women were anosmia [63% pregnant, 92% non-pregnant] and headache [72%, 62%]. Cardiopulmonary symptoms, including persistent cough [80%] and chest pain [73%], were more frequent among pregnant who were hospitalized. Consistent with observations in non-pregnant populations, lung disease and diabetes were associated with increased risk of more severe SARS-CoV-2 infection during pregnancy.</p>},
  author       = {Molteni, Erika and Astley, Christina M. and Ma, Wenjie and Sudre, Carole H. and Magee, Laura A. and Murray, Benjamin and Fall, Tove and Gomez, Maria F. and Tsereteli, Neli and Franks, Paul W. and Brownstein, John S. and Davies, Richard and Wolf, Jonathan and Spector, Tim D. and Ourselin, Sebastien and Steves, Claire J. and Chan, Andrew T. and Modat, Marc},
  issn         = {2045-2322},
  language     = {eng},
  number       = {1},
  publisher    = {Nature Publishing Group},
  series       = {Scientific Reports},
  title        = {Symptoms and syndromes associated with SARS-CoV-2 infection and severity in pregnant women from two community cohorts},
  url          = {http://dx.doi.org/10.1038/s41598-021-86452-3},
  doi          = {10.1038/s41598-021-86452-3},
  volume       = {11},
  year         = {2021},
}