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Levothyroxine treatment and incident dementia in adults with atrial fibrillation

Wändell, Per LU ; Carlsson, Axel C.; Li, Xinjun LU ; Sundquist, Jan LU and Sundquist, Kristina LU (2019) In Aging clinical and experimental research
Abstract

Objective: Levothyroxine treatment is common among older adults as is atrial fibrillation (AF), yet less is known about its potential effects on the development of dementia. Methods: The study population included all adults with diagnosed AF (n = 156,104) aged ≥ 45 years in Sweden without an earlier recorded diagnosis of dementia. Individuals with a dispensed prescription of levothyroxine on two or more occasions between July 1 2005 and December 31 2006 in Sweden were considered exposed (n = 12,978; 8.3%), and were compared to all other patients with AF without this treatment. Cox regression with hazard ratios (HRs) and 95% confidence interval (95% CI), with outcome defined as dementia of all causes between January 1, 2007 and December... (More)

Objective: Levothyroxine treatment is common among older adults as is atrial fibrillation (AF), yet less is known about its potential effects on the development of dementia. Methods: The study population included all adults with diagnosed AF (n = 156,104) aged ≥ 45 years in Sweden without an earlier recorded diagnosis of dementia. Individuals with a dispensed prescription of levothyroxine on two or more occasions between July 1 2005 and December 31 2006 in Sweden were considered exposed (n = 12,978; 8.3%), and were compared to all other patients with AF without this treatment. Cox regression with hazard ratios (HRs) and 95% confidence interval (95% CI), with outcome defined as dementia of all causes between January 1, 2007 and December 31, 2015, was used in the analysis. Adjustments were made for socio-demographic factors (age, immigration status, marital status, educational level, neighborhood socioeconomic status), co-morbidity (cardiovascular disease, obesity, diabetes, COPD, depression, anxiety and alcohol related diagnoses), and cardiovascular medications. Results: During follow-up, a total of 9054 patients with AF were diagnosed with dementia (5.8%). We found no significant association of levothyroxine treatment and incident dementia, fully adjusted HR 1.03 (95% CI 0.96–1.11), neither among men and women, nor in different age-groups or subgroups of dementia. Conclusion: We found no significant association of levothyroxine treatment and incident dementia among patients with AF, which contrasts some earlier findings.

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author
organization
publishing date
type
Contribution to journal
publication status
epub
subject
keywords
Alzheimer’s disease, Atrial fibrillation, Dementia, Drug treatment, Gender, Levothyroxine
in
Aging clinical and experimental research
publisher
Kurtis
external identifiers
  • scopus:85066892460
ISSN
1594-0667
DOI
10.1007/s40520-019-01217-3
language
English
LU publication?
yes
id
2c75fb41-253f-4203-806d-2435de982db0
date added to LUP
2019-06-24 13:56:09
date last changed
2019-07-16 04:12:23
@article{2c75fb41-253f-4203-806d-2435de982db0,
  abstract     = {<p>Objective: Levothyroxine treatment is common among older adults as is atrial fibrillation (AF), yet less is known about its potential effects on the development of dementia. Methods: The study population included all adults with diagnosed AF (n = 156,104) aged ≥ 45 years in Sweden without an earlier recorded diagnosis of dementia. Individuals with a dispensed prescription of levothyroxine on two or more occasions between July 1 2005 and December 31 2006 in Sweden were considered exposed (n = 12,978; 8.3%), and were compared to all other patients with AF without this treatment. Cox regression with hazard ratios (HRs) and 95% confidence interval (95% CI), with outcome defined as dementia of all causes between January 1, 2007 and December 31, 2015, was used in the analysis. Adjustments were made for socio-demographic factors (age, immigration status, marital status, educational level, neighborhood socioeconomic status), co-morbidity (cardiovascular disease, obesity, diabetes, COPD, depression, anxiety and alcohol related diagnoses), and cardiovascular medications. Results: During follow-up, a total of 9054 patients with AF were diagnosed with dementia (5.8%). We found no significant association of levothyroxine treatment and incident dementia, fully adjusted HR 1.03 (95% CI 0.96–1.11), neither among men and women, nor in different age-groups or subgroups of dementia. Conclusion: We found no significant association of levothyroxine treatment and incident dementia among patients with AF, which contrasts some earlier findings.</p>},
  author       = {Wändell, Per and Carlsson, Axel C. and Li, Xinjun and Sundquist, Jan and Sundquist, Kristina},
  issn         = {1594-0667},
  keyword      = {Alzheimer’s disease,Atrial fibrillation,Dementia,Drug treatment,Gender,Levothyroxine},
  language     = {eng},
  month        = {05},
  publisher    = {Kurtis},
  series       = {Aging clinical and experimental research},
  title        = {Levothyroxine treatment and incident dementia in adults with atrial fibrillation},
  url          = {http://dx.doi.org/10.1007/s40520-019-01217-3},
  year         = {2019},
}