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Pretreatment with MK-801 or the lazaroid U-83836E does not enhance striatal graft survival

Mundt-Petersen, Ulrika LU ; Karlsson, Jenny LU ; Kaminski Schierle, Gabriele S and Brundin, Patrik LU (2000) In Cell Transplantation 9(1). p.73-78
Abstract
A large proportion of grafted striatal neurons die, and mechanisms by which they succumb may involve excitotoxicity and oxidative stress. We investigated the effects of pretreatment of the graft tissue with the N-methyl-D-aspartate (NMDA) receptor antagonist (+)dizocilpine hydrogen maleate (MK-801) and lipid peroxidation inhibitor lazaroid U-83836E on the survival of transplanted striatal neurons. Neither compound increased the survival of grafts, suggesting that NMDA-related excitotoxicity or oxidative stress may not be primary mediators of cell death in striatal grafts.
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author
; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Cell Transplantation
volume
9
issue
1
pages
73 - 78
publisher
Cognizant Communication Corporation
external identifiers
  • scopus:0033933449
ISSN
0963-6897
DOI
10.1177/096368970000900110
language
English
LU publication?
yes
id
2c854eb2-3dee-440d-aee5-d10bcac06999
date added to LUP
2023-02-03 14:02:57
date last changed
2023-02-04 04:03:01
@article{2c854eb2-3dee-440d-aee5-d10bcac06999,
  abstract     = {{A large proportion of grafted striatal neurons die, and mechanisms by which they succumb may involve excitotoxicity and oxidative stress. We investigated the effects of pretreatment of the graft tissue with the N-methyl-D-aspartate (NMDA) receptor antagonist (+)dizocilpine hydrogen maleate (MK-801) and lipid peroxidation inhibitor lazaroid U-83836E on the survival of transplanted striatal neurons. Neither compound increased the survival of grafts, suggesting that NMDA-related excitotoxicity or oxidative stress may not be primary mediators of cell death in striatal grafts.}},
  author       = {{Mundt-Petersen, Ulrika and Karlsson, Jenny and Kaminski Schierle, Gabriele S and Brundin, Patrik}},
  issn         = {{0963-6897}},
  language     = {{eng}},
  month        = {{01}},
  number       = {{1}},
  pages        = {{73--78}},
  publisher    = {{Cognizant Communication Corporation}},
  series       = {{Cell Transplantation}},
  title        = {{Pretreatment with MK-801 or the lazaroid U-83836E does not enhance striatal graft survival}},
  url          = {{http://dx.doi.org/10.1177/096368970000900110}},
  doi          = {{10.1177/096368970000900110}},
  volume       = {{9}},
  year         = {{2000}},
}