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Antibodies against gonadotropin-releasing hormone in patients with posterior laryngitis.

Pendleton, Hillevi LU ; Alm, Ragnar LU ; Nordin Fredrikson, Gunilla LU and Ohlsson, Bodil LU (2013) In Drug Target Insights 7(Jan.,28). p.1-8
Abstract
Patients with functional gastrointestinal disorders express antibodies against gonadotropin-releasing hormone (GnRH) in serum. One common cause of posterior laryngitis (PL) is extra-esophageal reflux, but a functional etiology has also been suggested. The aim of this study was to scrutinize patients with PL with regard to the presence of GnRH antibodies and to examine the association between antibodies and symptoms and reflux. Consecutive PL patients were included after examination. Serum was analyzed for the presence of antibodies using an enzyme-linked immunosorbent assay (ELISA) method and expressed as relative units (RU). Two age- and gender-matched healthy subjects per case served as controls. The prevalence of IgM GnRH antibodies in... (More)
Patients with functional gastrointestinal disorders express antibodies against gonadotropin-releasing hormone (GnRH) in serum. One common cause of posterior laryngitis (PL) is extra-esophageal reflux, but a functional etiology has also been suggested. The aim of this study was to scrutinize patients with PL with regard to the presence of GnRH antibodies and to examine the association between antibodies and symptoms and reflux. Consecutive PL patients were included after examination. Serum was analyzed for the presence of antibodies using an enzyme-linked immunosorbent assay (ELISA) method and expressed as relative units (RU). Two age- and gender-matched healthy subjects per case served as controls. The prevalence of IgM GnRH antibodies in patients was 35% compared with 28% in controls (P = 0.06), with higher levels in patients (0.8 (0.3-2.2) RU) than in controls (0.2 (0.1-0.6) RU) (P = 0.007). The corresponding IgG antibody prevalences were 43% and 4%, respectively (P = 0.001), with no difference in levels (P = 0.70). There was no association between antibodies and clinical findings. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Drug Target Insights
volume
7
issue
Jan.,28
pages
1 - 8
publisher
Libertas Academica
external identifiers
  • pmid:23400339
  • scopus:84873328317
ISSN
1177-3928
DOI
10.4137/DTI.S10837
language
English
LU publication?
yes
id
2caa950e-e691-46c7-8841-54e4434aa87b (old id 3559909)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/23400339?dopt=Abstract
date added to LUP
2013-03-04 10:08:11
date last changed
2019-01-06 07:59:26
@article{2caa950e-e691-46c7-8841-54e4434aa87b,
  abstract     = {Patients with functional gastrointestinal disorders express antibodies against gonadotropin-releasing hormone (GnRH) in serum. One common cause of posterior laryngitis (PL) is extra-esophageal reflux, but a functional etiology has also been suggested. The aim of this study was to scrutinize patients with PL with regard to the presence of GnRH antibodies and to examine the association between antibodies and symptoms and reflux. Consecutive PL patients were included after examination. Serum was analyzed for the presence of antibodies using an enzyme-linked immunosorbent assay (ELISA) method and expressed as relative units (RU). Two age- and gender-matched healthy subjects per case served as controls. The prevalence of IgM GnRH antibodies in patients was 35% compared with 28% in controls (P = 0.06), with higher levels in patients (0.8 (0.3-2.2) RU) than in controls (0.2 (0.1-0.6) RU) (P = 0.007). The corresponding IgG antibody prevalences were 43% and 4%, respectively (P = 0.001), with no difference in levels (P = 0.70). There was no association between antibodies and clinical findings.},
  author       = {Pendleton, Hillevi and Alm, Ragnar and Nordin Fredrikson, Gunilla and Ohlsson, Bodil},
  issn         = {1177-3928},
  language     = {eng},
  number       = {Jan.,28},
  pages        = {1--8},
  publisher    = {Libertas Academica},
  series       = {Drug Target Insights},
  title        = {Antibodies against gonadotropin-releasing hormone in patients with posterior laryngitis.},
  url          = {http://dx.doi.org/10.4137/DTI.S10837},
  volume       = {7},
  year         = {2013},
}