Ten year follow-up of lung transplantations using initially rejected donor lungs after reconditioning using ex vivo lung perfusion
(2019) In Journal of Cardiothoracic Surgery 14(1).- Abstract
Background: In 2006 and 2007 we performed double lung transplantation with marginal donor lungs assessed and reconditioned by Ex Vivo Lung Perfusion (EVLP), using a technique developed by Professor Stig Steen. Here we present a 10-year follow-up comparing the outcomes of lung transplantations performed at our clinic using EVLP lungs vs. conventional lungs. Method: Between 2006 and 2007, 21 patients (6 EVLP, 15 conventional) underwent double lung transplantation (LTx) with follow-up on May 2017 at Lund University Hospital, Sweden. Pulmonary function was measured at 3/6/12 months, and annually thereafter for a period of 10 years in addition to survival and freedom from chronic lung allograft dysfunction (CLAD) being analyzed. Results:... (More)
Background: In 2006 and 2007 we performed double lung transplantation with marginal donor lungs assessed and reconditioned by Ex Vivo Lung Perfusion (EVLP), using a technique developed by Professor Stig Steen. Here we present a 10-year follow-up comparing the outcomes of lung transplantations performed at our clinic using EVLP lungs vs. conventional lungs. Method: Between 2006 and 2007, 21 patients (6 EVLP, 15 conventional) underwent double lung transplantation (LTx) with follow-up on May 2017 at Lund University Hospital, Sweden. Pulmonary function was measured at 3/6/12 months, and annually thereafter for a period of 10 years in addition to survival and freedom from chronic lung allograft dysfunction (CLAD) being analyzed. Results: Regarding Forced Expiratory Volume in 1 s (FEV1) and 6MWT at 3, 6, and 12 months and annually thereafter, no difference in median FEV1 nor 6MWT was found for EVLP-LTx vs. conventional-LTx (p > 0.05). No difference was shown in post-operative survival between EVLP-LTx vs. conventional LTx for patients with an overall survival up to 10-years (p > 0.05). The same pattern was shown in sub analyses for patients with a limited survival up to 1 and 5 years (p > 0.05). Conclusion: No superiority was found in conventional-LTx over EVLP-LTx, neither in long-term survival nor pulmonary function. No difference in CLAD-free survival was seen between the two groups. We believe that EVLP is a safe and effective method to use in LTx, greatly increasing the donor pool by improving marginal lungs and providing an objective assessment of the viability of marginal donor lungs.
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- author
- Ghaidan, Haider LU ; Fakhro, Mohammed LU ; Andreasson, Jesper LU ; Pierre, Leif LU ; Ingemansson, Richard LU and Lindstedt, Sandra LU
- organization
- publishing date
- 2019-07-01
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- EVLP, Long-term follow up, Lung function, Lung transplantation, Survival
- in
- Journal of Cardiothoracic Surgery
- volume
- 14
- issue
- 1
- article number
- 125
- publisher
- BioMed Central (BMC)
- external identifiers
-
- scopus:85068529548
- pmid:31262311
- ISSN
- 1749-8090
- DOI
- 10.1186/s13019-019-0948-1
- language
- English
- LU publication?
- yes
- id
- 2ce1b640-59f0-445a-a0ff-83bd4ab0c53d
- date added to LUP
- 2019-07-16 14:35:30
- date last changed
- 2024-04-30 17:49:19
@article{2ce1b640-59f0-445a-a0ff-83bd4ab0c53d, abstract = {{<p>Background: In 2006 and 2007 we performed double lung transplantation with marginal donor lungs assessed and reconditioned by Ex Vivo Lung Perfusion (EVLP), using a technique developed by Professor Stig Steen. Here we present a 10-year follow-up comparing the outcomes of lung transplantations performed at our clinic using EVLP lungs vs. conventional lungs. Method: Between 2006 and 2007, 21 patients (6 EVLP, 15 conventional) underwent double lung transplantation (LTx) with follow-up on May 2017 at Lund University Hospital, Sweden. Pulmonary function was measured at 3/6/12 months, and annually thereafter for a period of 10 years in addition to survival and freedom from chronic lung allograft dysfunction (CLAD) being analyzed. Results: Regarding Forced Expiratory Volume in 1 s (FEV1) and 6MWT at 3, 6, and 12 months and annually thereafter, no difference in median FEV1 nor 6MWT was found for EVLP-LTx vs. conventional-LTx (p > 0.05). No difference was shown in post-operative survival between EVLP-LTx vs. conventional LTx for patients with an overall survival up to 10-years (p > 0.05). The same pattern was shown in sub analyses for patients with a limited survival up to 1 and 5 years (p > 0.05). Conclusion: No superiority was found in conventional-LTx over EVLP-LTx, neither in long-term survival nor pulmonary function. No difference in CLAD-free survival was seen between the two groups. We believe that EVLP is a safe and effective method to use in LTx, greatly increasing the donor pool by improving marginal lungs and providing an objective assessment of the viability of marginal donor lungs.</p>}}, author = {{Ghaidan, Haider and Fakhro, Mohammed and Andreasson, Jesper and Pierre, Leif and Ingemansson, Richard and Lindstedt, Sandra}}, issn = {{1749-8090}}, keywords = {{EVLP; Long-term follow up; Lung function; Lung transplantation; Survival}}, language = {{eng}}, month = {{07}}, number = {{1}}, publisher = {{BioMed Central (BMC)}}, series = {{Journal of Cardiothoracic Surgery}}, title = {{Ten year follow-up of lung transplantations using initially rejected donor lungs after reconditioning using ex vivo lung perfusion}}, url = {{http://dx.doi.org/10.1186/s13019-019-0948-1}}, doi = {{10.1186/s13019-019-0948-1}}, volume = {{14}}, year = {{2019}}, }