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Pubertal bone growth in the femoral neck is predominantly characterized by increased bone size and not by increased bone density-a 4-year longitudinal study.

Sundberg, Martin LU ; Gärdsell, P; Johnell, Olof LU ; Ornstein, E; Karlsson, Magnus LU and Sernbo, I (2003) In Osteoporosis International 14(7). p.548-558
Abstract
Fragility fractures are correlated to reduced bone size and/or reduced volumetric bone density (vBMD). These region-specific deficits may originate from reduced mineral accrual and/or reduced skeletal growth during the first 2 decades of life. Before pathological development can be defined, normal skeletal growth must be described. To evaluate growth of bone size, accrual of bone mineral content (BMC), areal bone mineral density (aBMD) and vBMD in a population-based cohort, 44 boys and 42 girls were followed by annual measurements from the age of 12 to 16 (attendance rates 90–100%). Segmental bone length, bone width, BMC, aBMD and vBMD were measured by dual-energy X-ray absorptiometry (DXA). Data were compared with predicted adult peak, as... (More)
Fragility fractures are correlated to reduced bone size and/or reduced volumetric bone density (vBMD). These region-specific deficits may originate from reduced mineral accrual and/or reduced skeletal growth during the first 2 decades of life. Before pathological development can be defined, normal skeletal growth must be described. To evaluate growth of bone size, accrual of bone mineral content (BMC), areal bone mineral density (aBMD) and vBMD in a population-based cohort, 44 boys and 42 girls were followed by annual measurements from the age of 12 to 16 (attendance rates 90–100%). Segmental bone length, bone width, BMC, aBMD and vBMD were measured by dual-energy X-ray absorptiometry (DXA). Data were compared with predicted adult peak, as determined in 36 men aged 27.7±4.6 years and 44 women aged 26.8±4.9 years. Growth in width of the femoral neck precedes accrual of BMC in the femoral neck in both genders up to age 15. The girls were at all ages closer to their predicted adult peak in both bone width and BMC compared with the boys except in the femoral neck. As femoral neck vBMD had reached its predicted adult peak already at 12 years in both genders, the increase in femoral neck BMC and femoral neck aBMD from age 12 to 16 was most likely to be explained by the increase in bone size. In boys the peak velocity growth was recorded at ~14 years for BMC, height, width and lean mass. Growth from the age of 12 to 16 seems to build a bigger but not a denser skeleton in the femoral neck. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Adolescents, Bone mineral density, Growth, Longitudinal
in
Osteoporosis International
volume
14
issue
7
pages
548 - 558
publisher
Springer
external identifiers
  • wos:000184690100003
  • pmid:12730753
  • scopus:0042026866
ISSN
1433-2965
DOI
10.1007/s00198-003-1406-3
language
English
LU publication?
yes
id
2ceafdd3-fba5-4b2c-9336-1c8ea499fe39 (old id 114217)
date added to LUP
2007-07-30 14:41:57
date last changed
2018-10-04 13:51:08
@article{2ceafdd3-fba5-4b2c-9336-1c8ea499fe39,
  abstract     = {Fragility fractures are correlated to reduced bone size and/or reduced volumetric bone density (vBMD). These region-specific deficits may originate from reduced mineral accrual and/or reduced skeletal growth during the first 2 decades of life. Before pathological development can be defined, normal skeletal growth must be described. To evaluate growth of bone size, accrual of bone mineral content (BMC), areal bone mineral density (aBMD) and vBMD in a population-based cohort, 44 boys and 42 girls were followed by annual measurements from the age of 12 to 16 (attendance rates 90–100%). Segmental bone length, bone width, BMC, aBMD and vBMD were measured by dual-energy X-ray absorptiometry (DXA). Data were compared with predicted adult peak, as determined in 36 men aged 27.7±4.6 years and 44 women aged 26.8±4.9 years. Growth in width of the femoral neck precedes accrual of BMC in the femoral neck in both genders up to age 15. The girls were at all ages closer to their predicted adult peak in both bone width and BMC compared with the boys except in the femoral neck. As femoral neck vBMD had reached its predicted adult peak already at 12 years in both genders, the increase in femoral neck BMC and femoral neck aBMD from age 12 to 16 was most likely to be explained by the increase in bone size. In boys the peak velocity growth was recorded at ~14 years for BMC, height, width and lean mass. Growth from the age of 12 to 16 seems to build a bigger but not a denser skeleton in the femoral neck.},
  author       = {Sundberg, Martin and Gärdsell, P and Johnell, Olof and Ornstein, E and Karlsson, Magnus and Sernbo, I},
  issn         = {1433-2965},
  keyword      = {Adolescents,Bone mineral density,Growth,Longitudinal},
  language     = {eng},
  number       = {7},
  pages        = {548--558},
  publisher    = {Springer},
  series       = {Osteoporosis International},
  title        = {Pubertal bone growth in the femoral neck is predominantly characterized by increased bone size and not by increased bone density-a 4-year longitudinal study.},
  url          = {http://dx.doi.org/10.1007/s00198-003-1406-3},
  volume       = {14},
  year         = {2003},
}