Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

Changes in insulin-like growth factor 1 receptor density after transient cerebral ischemia in the rat : Lack of protection against ischemic brain damage following injection of insulin-like growth factor 1

Bergstedt, K. and Wieloch, T. LU (1993) In Journal of Cerebral Blood Flow and Metabolism 13(5). p.895-898
Abstract

Binding of 125I-insulin-like growth factor-1 (125I-IGF-1) to rat brain slices was studied after 15 min of two-vessel occlusion ischemia and 1 h to 4 days of recirculation. Ligand binding in the hippocampus increased at 6 h post ischemia in the CA1 and CA3 regions and the dentate gyrus, suggesting that the IGF-1 receptors were up-regulated, while no change was seen in neocortex and striatum. Intracerebroventricular injections of IGF-1 (2 μg) prior to and after transient cerebral ischemia did not reduce neuronal damage. The increased up-regulation on IGF-1 receptors and the absence of neuroprotection by IGF-1 suggest that the intracellular signal transduction chain activated by the IGF-1... (More)

Binding of 125I-insulin-like growth factor-1 (125I-IGF-1) to rat brain slices was studied after 15 min of two-vessel occlusion ischemia and 1 h to 4 days of recirculation. Ligand binding in the hippocampus increased at 6 h post ischemia in the CA1 and CA3 regions and the dentate gyrus, suggesting that the IGF-1 receptors were up-regulated, while no change was seen in neocortex and striatum. Intracerebroventricular injections of IGF-1 (2 μg) prior to and after transient cerebral ischemia did not reduce neuronal damage. The increased up-regulation on IGF-1 receptors and the absence of neuroprotection by IGF-1 suggest that the intracellular signal transduction chain activated by the IGF-1 receptor may be interrupted.

(Less)
Please use this url to cite or link to this publication:
author
and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Cerebral ischemia, Insulin-like growth factor 1, Neuronal damage, Protein synthesis
in
Journal of Cerebral Blood Flow and Metabolism
volume
13
issue
5
pages
4 pages
publisher
Nature Publishing Group
external identifiers
  • pmid:8360296
  • scopus:0027272556
ISSN
0271-678X
DOI
10.1038/jcbfm.1993.112
language
English
LU publication?
yes
id
2cfafd80-012b-4bfd-aeb2-954ad70ef206
date added to LUP
2019-06-13 16:21:28
date last changed
2025-10-14 11:21:59
@article{2cfafd80-012b-4bfd-aeb2-954ad70ef206,
  abstract     = {{<p>Binding of <sup>125</sup>I-insulin-like growth factor-1 (<sup>125</sup>I-IGF-1) to rat brain slices was studied after 15 min of two-vessel occlusion ischemia and 1 h to 4 days of recirculation. Ligand binding in the hippocampus increased at 6 h post ischemia in the CA<sub>1</sub> and CA<sub>3</sub> regions and the dentate gyrus, suggesting that the IGF-1 receptors were up-regulated, while no change was seen in neocortex and striatum. Intracerebroventricular injections of IGF-1 (2 μg) prior to and after transient cerebral ischemia did not reduce neuronal damage. The increased up-regulation on IGF-1 receptors and the absence of neuroprotection by IGF-1 suggest that the intracellular signal transduction chain activated by the IGF-1 receptor may be interrupted.</p>}},
  author       = {{Bergstedt, K. and Wieloch, T.}},
  issn         = {{0271-678X}},
  keywords     = {{Cerebral ischemia; Insulin-like growth factor 1; Neuronal damage; Protein synthesis}},
  language     = {{eng}},
  month        = {{01}},
  number       = {{5}},
  pages        = {{895--898}},
  publisher    = {{Nature Publishing Group}},
  series       = {{Journal of Cerebral Blood Flow and Metabolism}},
  title        = {{Changes in insulin-like growth factor 1 receptor density after transient cerebral ischemia in the rat : Lack of protection against ischemic brain damage following injection of insulin-like growth factor 1}},
  url          = {{http://dx.doi.org/10.1038/jcbfm.1993.112}},
  doi          = {{10.1038/jcbfm.1993.112}},
  volume       = {{13}},
  year         = {{1993}},
}