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Sacrificial redox modulation by a secreted bacterial effector molecule mitigates oxidative stress and inflammation in vivo

Andersson, Tilde LU ; Anwaar, Shoaib ; Fuentes-Lemus, Eduardo ; Allhorn, Maria LU ; Happonen, Lotta LU ; Veitch, Margaret ; Chew, Hui Yi ; Montes de Oca, Marcela ; Tanner, Lloyd LU and Brüggemann, Holger , et al. (2025) In Free Radical Biology and Medicine 240. p.339-346
Abstract

Human-bacterial interactions play a crucial role in several essential aspects of life. Here, we describe how a secreted protein from the skin commensal Cutibacterium acnes, RoxP, functions as a sacrificial redox effector molecule that facilitates beneficial interactions with its human host by counteracting oxidative stress and reducing stress-induced inflammation. Using a combination of structural mapping, biophysical binding studies, and in vivo experiments, we demonstrate how RoxP contributes to skin homeostasis by serving as a target for oxidative attack and influencing cytokine signaling. To our knowledge, this is the first in vivo mechanistic description of a secreted prokaryotic effector molecule modulating host redox balance... (More)

Human-bacterial interactions play a crucial role in several essential aspects of life. Here, we describe how a secreted protein from the skin commensal Cutibacterium acnes, RoxP, functions as a sacrificial redox effector molecule that facilitates beneficial interactions with its human host by counteracting oxidative stress and reducing stress-induced inflammation. Using a combination of structural mapping, biophysical binding studies, and in vivo experiments, we demonstrate how RoxP contributes to skin homeostasis by serving as a target for oxidative attack and influencing cytokine signaling. To our knowledge, this is the first in vivo mechanistic description of a secreted prokaryotic effector molecule modulating host redox balance through sacrificial oxidation, providing evidence of its role as a health-promoting factor.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Free Radical Biology and Medicine
volume
240
pages
339 - 346
publisher
Elsevier
external identifiers
  • scopus:105013859946
  • pmid:40849000
ISSN
0891-5849
DOI
10.1016/j.freeradbiomed.2025.08.038
language
English
LU publication?
yes
additional info
Publisher Copyright: © 2025 The Authors
id
2d5aa6f7-578c-48b5-a09b-2446e523ec21
date added to LUP
2025-09-10 12:53:34
date last changed
2025-11-05 18:20:50
@article{2d5aa6f7-578c-48b5-a09b-2446e523ec21,
  abstract     = {{<p>Human-bacterial interactions play a crucial role in several essential aspects of life. Here, we describe how a secreted protein from the skin commensal Cutibacterium acnes, RoxP, functions as a sacrificial redox effector molecule that facilitates beneficial interactions with its human host by counteracting oxidative stress and reducing stress-induced inflammation. Using a combination of structural mapping, biophysical binding studies, and in vivo experiments, we demonstrate how RoxP contributes to skin homeostasis by serving as a target for oxidative attack and influencing cytokine signaling. To our knowledge, this is the first in vivo mechanistic description of a secreted prokaryotic effector molecule modulating host redox balance through sacrificial oxidation, providing evidence of its role as a health-promoting factor.</p>}},
  author       = {{Andersson, Tilde and Anwaar, Shoaib and Fuentes-Lemus, Eduardo and Allhorn, Maria and Happonen, Lotta and Veitch, Margaret and Chew, Hui Yi and Montes de Oca, Marcela and Tanner, Lloyd and Brüggemann, Holger and Nordenfelt, Pontus and Davies, Michael J. and Wells, James W. and Lood, Rolf}},
  issn         = {{0891-5849}},
  language     = {{eng}},
  month        = {{12}},
  pages        = {{339--346}},
  publisher    = {{Elsevier}},
  series       = {{Free Radical Biology and Medicine}},
  title        = {{Sacrificial redox modulation by a secreted bacterial effector molecule mitigates oxidative stress and inflammation in vivo}},
  url          = {{http://dx.doi.org/10.1016/j.freeradbiomed.2025.08.038}},
  doi          = {{10.1016/j.freeradbiomed.2025.08.038}},
  volume       = {{240}},
  year         = {{2025}},
}