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Cutting edge : Evidence of direct TCR α-chain interaction with superantigen

Pumphrey, Nick; Vuidepot, Annelise; Jakobsen, Bent K; Forsberg, Göran; Walse, Björn LU and Lindkvist-Petersson, Karin LU (2007) In Journal of Immunology 179(5). p.2700-2704
Abstract

Superantigens are known to activate a large number of T cells. The SAg is presented by MHC class II on the APC and its classical feature is that it recognizes the variable region of the β-chain of the TCR. In this article, we report, by direct binding studies, that staphylococcal enterotoxin (SE) H (SEH), a bacterial SAg secreted by Staphylococcus aureus, instead recognizes the variable α-chain (TRAV27) of TCR. Furthermore, we show that different SAgs (e.g., SEH and SEA) can simultaneously bind to one TCR by binding the α-chain and the β-chain, respectively. Theoretical three-dimensional models of the penta complexes are presented. Hence, these findings open up a new dimension of the biology of the staphylococcal enterotoxins.

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author
publishing date
type
Contribution to journal
publication status
published
in
Journal of Immunology
volume
179
issue
5
pages
2700 - 2704
publisher
American Association of Immunologists
external identifiers
  • scopus:38449085891
ISSN
0022-1767
language
English
LU publication?
no
id
2d7421d2-8ebd-4757-9d48-2bcf15721958
date added to LUP
2017-02-15 15:05:56
date last changed
2017-03-10 12:11:47
@article{2d7421d2-8ebd-4757-9d48-2bcf15721958,
  abstract     = {<p>Superantigens are known to activate a large number of T cells. The SAg is presented by MHC class II on the APC and its classical feature is that it recognizes the variable region of the β-chain of the TCR. In this article, we report, by direct binding studies, that staphylococcal enterotoxin (SE) H (SEH), a bacterial SAg secreted by Staphylococcus aureus, instead recognizes the variable α-chain (TRAV27) of TCR. Furthermore, we show that different SAgs (e.g., SEH and SEA) can simultaneously bind to one TCR by binding the α-chain and the β-chain, respectively. Theoretical three-dimensional models of the penta complexes are presented. Hence, these findings open up a new dimension of the biology of the staphylococcal enterotoxins.</p>},
  author       = {Pumphrey, Nick and Vuidepot, Annelise and Jakobsen, Bent K and Forsberg, Göran and Walse, Björn and Lindkvist-Petersson, Karin},
  issn         = {0022-1767},
  language     = {eng},
  month        = {09},
  number       = {5},
  pages        = {2700--2704},
  publisher    = {American Association of Immunologists},
  series       = {Journal of Immunology},
  title        = {Cutting edge : Evidence of direct TCR α-chain interaction with superantigen},
  volume       = {179},
  year         = {2007},
}