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Cutting edge : Evidence of direct TCR α-chain interaction with superantigen

Pumphrey, Nick ; Vuidepot, Annelise ; Jakobsen, Bent K ; Forsberg, Göran ; Walse, Björn LU and Lindkvist-Petersson, Karin LU (2007) In Journal of Immunology 179(5). p.2700-2704
Abstract

Superantigens are known to activate a large number of T cells. The SAg is presented by MHC class II on the APC and its classical feature is that it recognizes the variable region of the β-chain of the TCR. In this article, we report, by direct binding studies, that staphylococcal enterotoxin (SE) H (SEH), a bacterial SAg secreted by Staphylococcus aureus, instead recognizes the variable α-chain (TRAV27) of TCR. Furthermore, we show that different SAgs (e.g., SEH and SEA) can simultaneously bind to one TCR by binding the α-chain and the β-chain, respectively. Theoretical three-dimensional models of the penta complexes are presented. Hence, these findings open up a new dimension of the biology of the staphylococcal enterotoxins.

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author
; ; ; ; and
publishing date
type
Contribution to journal
publication status
published
in
Journal of Immunology
volume
179
issue
5
pages
2700 - 2704
publisher
American Association of Immunologists
external identifiers
  • scopus:38449085891
  • pmid:17709482
ISSN
0022-1767
language
English
LU publication?
no
id
2d7421d2-8ebd-4757-9d48-2bcf15721958
date added to LUP
2017-02-15 15:05:56
date last changed
2024-02-29 08:54:21
@article{2d7421d2-8ebd-4757-9d48-2bcf15721958,
  abstract     = {{<p>Superantigens are known to activate a large number of T cells. The SAg is presented by MHC class II on the APC and its classical feature is that it recognizes the variable region of the β-chain of the TCR. In this article, we report, by direct binding studies, that staphylococcal enterotoxin (SE) H (SEH), a bacterial SAg secreted by Staphylococcus aureus, instead recognizes the variable α-chain (TRAV27) of TCR. Furthermore, we show that different SAgs (e.g., SEH and SEA) can simultaneously bind to one TCR by binding the α-chain and the β-chain, respectively. Theoretical three-dimensional models of the penta complexes are presented. Hence, these findings open up a new dimension of the biology of the staphylococcal enterotoxins.</p>}},
  author       = {{Pumphrey, Nick and Vuidepot, Annelise and Jakobsen, Bent K and Forsberg, Göran and Walse, Björn and Lindkvist-Petersson, Karin}},
  issn         = {{0022-1767}},
  language     = {{eng}},
  month        = {{09}},
  number       = {{5}},
  pages        = {{2700--2704}},
  publisher    = {{American Association of Immunologists}},
  series       = {{Journal of Immunology}},
  title        = {{Cutting edge : Evidence of direct TCR α-chain interaction with superantigen}},
  volume       = {{179}},
  year         = {{2007}},
}