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Longitudinal strain from velocity encoded cardiovascular magnetic resonance: a validation study

Heiberg, Einar LU ; Pahlm, Ulrika LU ; Agarwal, Shruti LU ; Bergvall, Erik LU ; Fransson, Helen LU ; Steding Ehrenborg, Katarina LU ; Carlsson, Marcus LU and Arheden, Håkan LU (2013) In Journal of Cardiovascular Magnetic Resonance 15.
Abstract
Background: Regional myocardial function is typically evaluated by visual assessment by experienced users, or by methods requiring substantial post processing time. Visual assessment is subjective and not quantitative. Therefore, the purpose of this study is to develop and validate a simple method to derive quantitative measures of regional wall function from velocity encoded Cardiovascular Magnetic Resonance (CMR), and provide associated normal values for longitudinal strain. Method: Both fast field echo (FFE) and turbo field echo (TFE) velocity encoded CMR images were acquired in three long axis planes in 36 healthy volunteers (13 women, 23 men), age 35 +/- 12 years. Strain was also quantified in 10 patients within one week after... (More)
Background: Regional myocardial function is typically evaluated by visual assessment by experienced users, or by methods requiring substantial post processing time. Visual assessment is subjective and not quantitative. Therefore, the purpose of this study is to develop and validate a simple method to derive quantitative measures of regional wall function from velocity encoded Cardiovascular Magnetic Resonance (CMR), and provide associated normal values for longitudinal strain. Method: Both fast field echo (FFE) and turbo field echo (TFE) velocity encoded CMR images were acquired in three long axis planes in 36 healthy volunteers (13 women, 23 men), age 35 +/- 12 years. Strain was also quantified in 10 patients within one week after myocardial infarction. The user manually delineated myocardium in one time frame and strain was calculated as the myocardium was tracked throughout the cardiac cycle using an optimization formulation and mechanical a priori assumptions. A phantom experiment was performed to validate the method with optical tracking of deformation as an independent gold standard. Results: There was an excellent agreement between longitudinal strain measured by optical tracking and longitudinal strain measured with TFE velocity encoding. Difference between the two methods was 0.0025 +/- 0.085 (ns). Mean global longitudinal strain in the 36 healthy volunteers was -0.18 +/- 0.10 (TFE imaging). Intra-observer variability for all segments was 0.00 +/- 0.06. Inter-observer variability was -0.02 +/- 0.07 (TFE imaging). The intra-observer variability for radial strain was high limiting the applicability of radial strain. Mean longitudinal strain in patients was significantly lower (-0.15 +/- 0.12) compared to healthy volunteers (p<0.05). Strain (expressed as percentage of normal strain) in infarcted regions was lower compared to remote areas (p<0.01). Conclusion: In conclusion, we have developed and validated a robust and clinically applicable technique that can quantify longitudinal strain and regional myocardial wall function and present the associated normal values for longitudinal strain. (Less)
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Contribution to journal
publication status
published
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in
Journal of Cardiovascular Magnetic Resonance
volume
15
article number
15
publisher
BioMed Central
external identifiers
  • wos:000315380400002
  • scopus:84872543950
ISSN
1097-6647
DOI
10.1186/1532-429X-15-15
language
English
LU publication?
yes
id
2dad3c32-5038-41d1-9b8d-297adc9299fa (old id 3674726)
date added to LUP
2016-04-01 10:10:06
date last changed
2020-01-15 01:18:55
@article{2dad3c32-5038-41d1-9b8d-297adc9299fa,
  abstract     = {Background: Regional myocardial function is typically evaluated by visual assessment by experienced users, or by methods requiring substantial post processing time. Visual assessment is subjective and not quantitative. Therefore, the purpose of this study is to develop and validate a simple method to derive quantitative measures of regional wall function from velocity encoded Cardiovascular Magnetic Resonance (CMR), and provide associated normal values for longitudinal strain. Method: Both fast field echo (FFE) and turbo field echo (TFE) velocity encoded CMR images were acquired in three long axis planes in 36 healthy volunteers (13 women, 23 men), age 35 +/- 12 years. Strain was also quantified in 10 patients within one week after myocardial infarction. The user manually delineated myocardium in one time frame and strain was calculated as the myocardium was tracked throughout the cardiac cycle using an optimization formulation and mechanical a priori assumptions. A phantom experiment was performed to validate the method with optical tracking of deformation as an independent gold standard. Results: There was an excellent agreement between longitudinal strain measured by optical tracking and longitudinal strain measured with TFE velocity encoding. Difference between the two methods was 0.0025 +/- 0.085 (ns). Mean global longitudinal strain in the 36 healthy volunteers was -0.18 +/- 0.10 (TFE imaging). Intra-observer variability for all segments was 0.00 +/- 0.06. Inter-observer variability was -0.02 +/- 0.07 (TFE imaging). The intra-observer variability for radial strain was high limiting the applicability of radial strain. Mean longitudinal strain in patients was significantly lower (-0.15 +/- 0.12) compared to healthy volunteers (p&lt;0.05). Strain (expressed as percentage of normal strain) in infarcted regions was lower compared to remote areas (p&lt;0.01). Conclusion: In conclusion, we have developed and validated a robust and clinically applicable technique that can quantify longitudinal strain and regional myocardial wall function and present the associated normal values for longitudinal strain.},
  author       = {Heiberg, Einar and Pahlm, Ulrika and Agarwal, Shruti and Bergvall, Erik and Fransson, Helen and Steding Ehrenborg, Katarina and Carlsson, Marcus and Arheden, Håkan},
  issn         = {1097-6647},
  language     = {eng},
  publisher    = {BioMed Central},
  series       = {Journal of Cardiovascular Magnetic Resonance},
  title        = {Longitudinal strain from velocity encoded cardiovascular magnetic resonance: a validation study},
  url          = {https://lup.lub.lu.se/search/ws/files/1619024/4016156.pdf},
  doi          = {10.1186/1532-429X-15-15},
  volume       = {15},
  year         = {2013},
}