Advanced

Can 2-oxoglutarate prevent changes in bone evoked by omeprazole?

Dobrowolski, Piotr; Tomaszewska, Ewa; Radzki, Radoslaw P.; Bienko, Marek; Wydrych, Jerzy; Zdybel, Adam and Pierzynowski, Stefan LU (2013) In Nutrition 29(3). p.556-561
Abstract
Objective: Proton-pump inhibitors, such as omeprazole, are widely used in the prevention and treatment of gastroesophageal diseases. However, an association between proton-pump inhibitors and the increased risk of bone fractures has been observed, especially in patients treated for extended periods. Conversely, 2-oxoglutarate, a precursor of hydroxyproline, the most abundant amino acid in bone collagen, counteracts the bone loss. The aim of the present study was to elucidate the influence of omeprazole on bone and investigate whether dietary 2-oxoglutarate supplementation could prevent the effects of omeprazole. Methods: Eighteen male Sprague-Dawley rats were used. Rats received omeprazole in the diet and 2-oxoglutarate in the drinking... (More)
Objective: Proton-pump inhibitors, such as omeprazole, are widely used in the prevention and treatment of gastroesophageal diseases. However, an association between proton-pump inhibitors and the increased risk of bone fractures has been observed, especially in patients treated for extended periods. Conversely, 2-oxoglutarate, a precursor of hydroxyproline, the most abundant amino acid in bone collagen, counteracts the bone loss. The aim of the present study was to elucidate the influence of omeprazole on bone and investigate whether dietary 2-oxoglutarate supplementation could prevent the effects of omeprazole. Methods: Eighteen male Sprague-Dawley rats were used. Rats received omeprazole in the diet and 2-oxoglutarate in the drinking water. Body and organ weights and serum concentrations of cholecystokinin and gastrin were measured. The femurs, tibias, and calvarias were collected. Histomorphometric analysis of bone and cartilage tissues was conducted. Bone densitometric and peripheral quantitative computed tomographic analyses of the femur and tibia were performed. Results: Omeprazole decreased the femur and tibia weights, the mechanical properties of the femur, the volumetric bone density and content, the trabecular and cortical bone mineral content, the total, trabecular, and cortical bone areas, the mean cortical thickness, and the periosteal circumference of the femur. Omeprazole had a minor effect on the examined bone morphology and exerted negligible effects on the cartilage. 2-Oxoglutarate lowered the gastrin concentration. Conclusions: Omeprazole treatment exerts its effects mostly on bone mineralization and cancellous bone, adversely affecting bone properties. This adverse effect of omeprazole was not markedly abolished by 2-oxoglutaric acid, which acted as an anti-hypergastrinemic agent. (C) 2013 Elsevier Inc. All rights reserved. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Omeprazole, 2-Oxoglutarate, Hypergastrinemia, Bone
in
Nutrition
volume
29
issue
3
pages
556 - 561
publisher
Elsevier
external identifiers
  • wos:000316437600014
  • scopus:84873566894
ISSN
1873-1244
DOI
10.1016/j.nut.2012.07.014
language
English
LU publication?
yes
id
2db4ba1b-6c21-4ceb-aa9d-76c522685a42 (old id 3761017)
date added to LUP
2013-05-20 12:15:24
date last changed
2019-08-11 03:19:59
@article{2db4ba1b-6c21-4ceb-aa9d-76c522685a42,
  abstract     = {Objective: Proton-pump inhibitors, such as omeprazole, are widely used in the prevention and treatment of gastroesophageal diseases. However, an association between proton-pump inhibitors and the increased risk of bone fractures has been observed, especially in patients treated for extended periods. Conversely, 2-oxoglutarate, a precursor of hydroxyproline, the most abundant amino acid in bone collagen, counteracts the bone loss. The aim of the present study was to elucidate the influence of omeprazole on bone and investigate whether dietary 2-oxoglutarate supplementation could prevent the effects of omeprazole. Methods: Eighteen male Sprague-Dawley rats were used. Rats received omeprazole in the diet and 2-oxoglutarate in the drinking water. Body and organ weights and serum concentrations of cholecystokinin and gastrin were measured. The femurs, tibias, and calvarias were collected. Histomorphometric analysis of bone and cartilage tissues was conducted. Bone densitometric and peripheral quantitative computed tomographic analyses of the femur and tibia were performed. Results: Omeprazole decreased the femur and tibia weights, the mechanical properties of the femur, the volumetric bone density and content, the trabecular and cortical bone mineral content, the total, trabecular, and cortical bone areas, the mean cortical thickness, and the periosteal circumference of the femur. Omeprazole had a minor effect on the examined bone morphology and exerted negligible effects on the cartilage. 2-Oxoglutarate lowered the gastrin concentration. Conclusions: Omeprazole treatment exerts its effects mostly on bone mineralization and cancellous bone, adversely affecting bone properties. This adverse effect of omeprazole was not markedly abolished by 2-oxoglutaric acid, which acted as an anti-hypergastrinemic agent. (C) 2013 Elsevier Inc. All rights reserved.},
  author       = {Dobrowolski, Piotr and Tomaszewska, Ewa and Radzki, Radoslaw P. and Bienko, Marek and Wydrych, Jerzy and Zdybel, Adam and Pierzynowski, Stefan},
  issn         = {1873-1244},
  keyword      = {Omeprazole,2-Oxoglutarate,Hypergastrinemia,Bone},
  language     = {eng},
  number       = {3},
  pages        = {556--561},
  publisher    = {Elsevier},
  series       = {Nutrition},
  title        = {Can 2-oxoglutarate prevent changes in bone evoked by omeprazole?},
  url          = {http://dx.doi.org/10.1016/j.nut.2012.07.014},
  volume       = {29},
  year         = {2013},
}