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Incidence and familial risk of pleural mesothelioma in Sweden : A national cohort study

Ji, Jianguang LU ; Sundquist, Jan LU and Sundquist, Kristina LU (2016) In European Respiratory Journal 48(3). p.873-879
Abstract

Familial clustering of pleural mesothelioma was reported previously, but none of the reports quantified the familial risk of mesothelioma or the association with other cancers. The contributions of shared environmental or genetic factors to the aggregation of mesothelioma were unknown. We used a number of Swedish registers, including the Swedish Multigeneration Register and the Swedish Cancer Register, to examine the familial risk of mesothelioma in offspring. Standardised incidence ratios (SIRs) were used to calculate the risk. Age standardised incidence rates of mesothelioma were calculated from the Swedish Cancer Registry. The incidence of mesothelioma reached its peak rate in 2000 and decreased thereafter. Risk of mesothelioma was... (More)

Familial clustering of pleural mesothelioma was reported previously, but none of the reports quantified the familial risk of mesothelioma or the association with other cancers. The contributions of shared environmental or genetic factors to the aggregation of mesothelioma were unknown. We used a number of Swedish registers, including the Swedish Multigeneration Register and the Swedish Cancer Register, to examine the familial risk of mesothelioma in offspring. Standardised incidence ratios (SIRs) were used to calculate the risk. Age standardised incidence rates of mesothelioma were calculated from the Swedish Cancer Registry. The incidence of mesothelioma reached its peak rate in 2000 and decreased thereafter. Risk of mesothelioma was significantly increased when parents or siblings were diagnosed with mesothelioma, with SIRs of 3.88 (95% CI 1.01-10.04) and 12.37 (95% CI 5.89-22.84), respectively. Mesothelioma was associated with kidney (SIR 2.13, 95% CI 1.16-3.59) and bladder cancers (SIR 2.09, 95% CI 1.32-3.14) in siblings. No association was found between spouses. Family history of mesothelioma, including both parental and sibling history, is an important risk factor for mesothelioma. Shared genetic factors may contribute to the observed familial clustering of mesothelioma, but the contribution of shared environmental factors could not be neglected. The association with kidney and bladder cancers calls for further study to explore the underlying mechanisms.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
European Respiratory Journal
volume
48
issue
3
pages
7 pages
publisher
Eur Respiratory Soc
external identifiers
  • scopus:84986219198
  • wos:000388304800035
ISSN
0903-1936
DOI
10.1183/13993003.00091-2016
language
English
LU publication?
yes
id
2e7bc226-4c2e-4dbf-91f3-c4d0cc4f966d
date added to LUP
2016-12-12 14:46:32
date last changed
2017-09-18 11:31:07
@article{2e7bc226-4c2e-4dbf-91f3-c4d0cc4f966d,
  abstract     = {<p>Familial clustering of pleural mesothelioma was reported previously, but none of the reports quantified the familial risk of mesothelioma or the association with other cancers. The contributions of shared environmental or genetic factors to the aggregation of mesothelioma were unknown. We used a number of Swedish registers, including the Swedish Multigeneration Register and the Swedish Cancer Register, to examine the familial risk of mesothelioma in offspring. Standardised incidence ratios (SIRs) were used to calculate the risk. Age standardised incidence rates of mesothelioma were calculated from the Swedish Cancer Registry. The incidence of mesothelioma reached its peak rate in 2000 and decreased thereafter. Risk of mesothelioma was significantly increased when parents or siblings were diagnosed with mesothelioma, with SIRs of 3.88 (95% CI 1.01-10.04) and 12.37 (95% CI 5.89-22.84), respectively. Mesothelioma was associated with kidney (SIR 2.13, 95% CI 1.16-3.59) and bladder cancers (SIR 2.09, 95% CI 1.32-3.14) in siblings. No association was found between spouses. Family history of mesothelioma, including both parental and sibling history, is an important risk factor for mesothelioma. Shared genetic factors may contribute to the observed familial clustering of mesothelioma, but the contribution of shared environmental factors could not be neglected. The association with kidney and bladder cancers calls for further study to explore the underlying mechanisms.</p>},
  author       = {Ji, Jianguang and Sundquist, Jan and Sundquist, Kristina},
  issn         = {0903-1936},
  language     = {eng},
  month        = {09},
  number       = {3},
  pages        = {873--879},
  publisher    = {Eur Respiratory Soc},
  series       = {European Respiratory Journal},
  title        = {Incidence and familial risk of pleural mesothelioma in Sweden : A national cohort study},
  url          = {http://dx.doi.org/10.1183/13993003.00091-2016},
  volume       = {48},
  year         = {2016},
}