Muscle preservation in proximal nerve injuries : a current update
Lysak, Andrii ; Farnebo, Simon ; Geuna, Stefano and Dahlin, Lars B. LU
(2024)
In Journal of Hand Surgery: European Volume
49(6).
p.773-782
- Abstract
Optimal recovery of muscle function after proximal nerve injuries remains a complex and challenging problem. After a nerve injury, alterations in the affected muscles lead to atrophy, and later degeneration and replacement by fat-fibrous tissues. At present, several different strategies for the preservation of skeletal muscle have been reported, including various sets of physical exercises, muscle massage, physical methods (e.g. electrical stimulation, magnetic field and laser stimulation, low-intensity pulsed ultrasound), medicines (e.g. nutrients, natural and chemical agents, anti-inflammatory and antioxidants, hormones, enzymes and enzyme inhibitors), regenerative medicine (e.g. growth factors, stem cells and microbiota) and surgical... (More)
Optimal recovery of muscle function after proximal nerve injuries remains a complex and challenging problem. After a nerve injury, alterations in the affected muscles lead to atrophy, and later degeneration and replacement by fat-fibrous tissues. At present, several different strategies for the preservation of skeletal muscle have been reported, including various sets of physical exercises, muscle massage, physical methods (e.g. electrical stimulation, magnetic field and laser stimulation, low-intensity pulsed ultrasound), medicines (e.g. nutrients, natural and chemical agents, anti-inflammatory and antioxidants, hormones, enzymes and enzyme inhibitors), regenerative medicine (e.g. growth factors, stem cells and microbiota) and surgical procedures (e.g. supercharge end-to-side neurotization). The present review will focus on methods that aimed to minimize the damage to muscles after denervation based on our present knowledge.
(Less)
- author
- Lysak, Andrii
; Farnebo, Simon
; Geuna, Stefano
and Dahlin, Lars B.
LU
- organization
- publishing date
- 2024-06
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- denervation, muscle electrostimulation, muscle preservation, nerve injury, regenerative medicine, Skeletal muscle
- in
- Journal of Hand Surgery: European Volume
- volume
- 49
- issue
- 6
- pages
- 10 pages
- publisher
- SAGE Publications
- external identifiers
-
- pmid:38819009
- scopus:85195011148
- ISSN
- 1753-1934
- DOI
- 10.1177/17531934231216646
- language
- English
- LU publication?
- yes
- id
- 2e9aa051-a215-4f2d-ad94-a78d544d3b98
- date added to LUP
- 2024-08-21 14:26:53
- date last changed
- 2025-07-10 20:48:45
@article{2e9aa051-a215-4f2d-ad94-a78d544d3b98,
abstract = {{<p>Optimal recovery of muscle function after proximal nerve injuries remains a complex and challenging problem. After a nerve injury, alterations in the affected muscles lead to atrophy, and later degeneration and replacement by fat-fibrous tissues. At present, several different strategies for the preservation of skeletal muscle have been reported, including various sets of physical exercises, muscle massage, physical methods (e.g. electrical stimulation, magnetic field and laser stimulation, low-intensity pulsed ultrasound), medicines (e.g. nutrients, natural and chemical agents, anti-inflammatory and antioxidants, hormones, enzymes and enzyme inhibitors), regenerative medicine (e.g. growth factors, stem cells and microbiota) and surgical procedures (e.g. supercharge end-to-side neurotization). The present review will focus on methods that aimed to minimize the damage to muscles after denervation based on our present knowledge.</p>}},
author = {{Lysak, Andrii and Farnebo, Simon and Geuna, Stefano and Dahlin, Lars B.}},
issn = {{1753-1934}},
keywords = {{denervation; muscle electrostimulation; muscle preservation; nerve injury; regenerative medicine; Skeletal muscle}},
language = {{eng}},
number = {{6}},
pages = {{773--782}},
publisher = {{SAGE Publications}},
series = {{Journal of Hand Surgery: European Volume}},
title = {{Muscle preservation in proximal nerve injuries : a current update}},
url = {{http://dx.doi.org/10.1177/17531934231216646}},
doi = {{10.1177/17531934231216646}},
volume = {{49}},
year = {{2024}},
}