Effect of Continuous Positive Airway Pressure on Lipid Profiles in Obstructive Sleep Apnea : A Meta-Analysis
(2022) In Journal of Clinical Medicine 11(3).- Abstract
Background: Obstructive sleep apnea (OSA) is associated with dyslipidemia. However, the effects of continuous positive airway pressure (CPAP) treatment on lipid profiles are unclear. Methods: PubMed/Medline, Embase and Cochrane were searched up to July 2021. Randomized controlled trials (RCTs) of CPAP versus controls with ≥4 weeks treatment and reported pre-and post-intervention lipid profiles were included. Weighted mean difference (WMD) was used to assess the effect size. Meta-regression was used to explore the potential moderators of post-CPAP treatment changes in lipid profiles. Results: A total of 14 RCTs with 1792 subjects were included. CPAP treatment was associated with a significant decrease in total cholesterol compared to... (More)
Background: Obstructive sleep apnea (OSA) is associated with dyslipidemia. However, the effects of continuous positive airway pressure (CPAP) treatment on lipid profiles are unclear. Methods: PubMed/Medline, Embase and Cochrane were searched up to July 2021. Randomized controlled trials (RCTs) of CPAP versus controls with ≥4 weeks treatment and reported pre-and post-intervention lipid profiles were included. Weighted mean difference (WMD) was used to assess the effect size. Meta-regression was used to explore the potential moderators of post-CPAP treatment changes in lipid profiles. Results: A total of 14 RCTs with 1792 subjects were included. CPAP treatment was associated with a significant decrease in total cholesterol compared to controls (WMD = −0.098 mmol/L, 95% CI = −0.169 to −0.027, p = 0.007, I2 = 0.0%). No significant changes in triglyceride, high-density lipoprotein nor low-density lipoprotein were observed after CPAP treatment (all p > 0.2). Furthermore, meta-regression models showed that age, gender, body mass index, daytime sleepiness, OSA severity, follow-up study duration, CPAP compliance nor patients with cardiometabolic disease did not moderate the effects of CPAP treatment on lipid profiles (all p > 0.05). Conclusions: CPAP treatment decreases total cholesterol at a small magnitude but has no effect on other markers of dyslipidemia in OSA patients. Future studies of CPAP therapy should target combined treatment strategies with lifestyle modifications and/or anti-hyperlipidemic medications in the primary as well as secondary cardiovascular prevention models.
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- author
- Chen, Baixin ; Guo, Miaolan ; Peker, Yüksel LU ; Salord, Neus ; Drager, Luciano F. ; Lorenzi-Filho, Geraldo ; Tang, Xiangdong and Li, Yun
- organization
- publishing date
- 2022
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Continuous positive airway pressure, Lipid profile, Obstructive sleep apnea, Total cholesterol
- in
- Journal of Clinical Medicine
- volume
- 11
- issue
- 3
- article number
- 596
- publisher
- MDPI AG
- external identifiers
-
- pmid:35160050
- scopus:85123380276
- ISSN
- 2077-0383
- DOI
- 10.3390/jcm11030596
- language
- English
- LU publication?
- yes
- id
- 2f2ac94b-54ed-4a65-a569-d1c00c54e6cf
- date added to LUP
- 2022-03-18 14:33:15
- date last changed
- 2024-07-11 13:47:58
@article{2f2ac94b-54ed-4a65-a569-d1c00c54e6cf, abstract = {{<p>Background: Obstructive sleep apnea (OSA) is associated with dyslipidemia. However, the effects of continuous positive airway pressure (CPAP) treatment on lipid profiles are unclear. Methods: PubMed/Medline, Embase and Cochrane were searched up to July 2021. Randomized controlled trials (RCTs) of CPAP versus controls with ≥4 weeks treatment and reported pre-and post-intervention lipid profiles were included. Weighted mean difference (WMD) was used to assess the effect size. Meta-regression was used to explore the potential moderators of post-CPAP treatment changes in lipid profiles. Results: A total of 14 RCTs with 1792 subjects were included. CPAP treatment was associated with a significant decrease in total cholesterol compared to controls (WMD = −0.098 mmol/L, 95% CI = −0.169 to −0.027, p = 0.007, I<sup>2</sup> = 0.0%). No significant changes in triglyceride, high-density lipoprotein nor low-density lipoprotein were observed after CPAP treatment (all p > 0.2). Furthermore, meta-regression models showed that age, gender, body mass index, daytime sleepiness, OSA severity, follow-up study duration, CPAP compliance nor patients with cardiometabolic disease did not moderate the effects of CPAP treatment on lipid profiles (all p > 0.05). Conclusions: CPAP treatment decreases total cholesterol at a small magnitude but has no effect on other markers of dyslipidemia in OSA patients. Future studies of CPAP therapy should target combined treatment strategies with lifestyle modifications and/or anti-hyperlipidemic medications in the primary as well as secondary cardiovascular prevention models.</p>}}, author = {{Chen, Baixin and Guo, Miaolan and Peker, Yüksel and Salord, Neus and Drager, Luciano F. and Lorenzi-Filho, Geraldo and Tang, Xiangdong and Li, Yun}}, issn = {{2077-0383}}, keywords = {{Continuous positive airway pressure; Lipid profile; Obstructive sleep apnea; Total cholesterol}}, language = {{eng}}, number = {{3}}, publisher = {{MDPI AG}}, series = {{Journal of Clinical Medicine}}, title = {{Effect of Continuous Positive Airway Pressure on Lipid Profiles in Obstructive Sleep Apnea : A Meta-Analysis}}, url = {{http://dx.doi.org/10.3390/jcm11030596}}, doi = {{10.3390/jcm11030596}}, volume = {{11}}, year = {{2022}}, }