Residential exposure to transportation noise in Denmark and incidence of dementia : national cohort study
(2021) In BMJ (Clinical research ed.) 374.- Abstract
OBJECTIVE: To investigate the association between long term residential exposure to road traffic and railway noise and risk of incident dementia.
DESIGN: Nationwide prospective register based cohort study.
SETTING: Denmark.
PARTICIPANTS: 1 938 994 adults aged ≥60 years living in Denmark between 1 January 2004 and 31 December 2017.
MAIN OUTCOME MEASURES: Incident cases of all cause dementia and dementia subtypes (Alzheimer's disease, vascular dementia, and Parkinson's disease related dementia), identified from national hospital and prescription registries.
RESULTS: The study population included 103 500 participants with incident dementia, and of those, 31 219 received a diagnosis of Alzheimer's disease, 8664... (More)
OBJECTIVE: To investigate the association between long term residential exposure to road traffic and railway noise and risk of incident dementia.
DESIGN: Nationwide prospective register based cohort study.
SETTING: Denmark.
PARTICIPANTS: 1 938 994 adults aged ≥60 years living in Denmark between 1 January 2004 and 31 December 2017.
MAIN OUTCOME MEASURES: Incident cases of all cause dementia and dementia subtypes (Alzheimer's disease, vascular dementia, and Parkinson's disease related dementia), identified from national hospital and prescription registries.
RESULTS: The study population included 103 500 participants with incident dementia, and of those, 31 219 received a diagnosis of Alzheimer's disease, 8664 of vascular dementia, and 2192 of Parkinson's disease related dementia. Using Cox regression models, 10 year mean exposure to road traffic and railway noise at the most (Ldenmax) and least (Ldenmin) exposed façades of buildings were associated with a higher risk of all cause dementia. These associations showed a general pattern of higher hazard ratios with higher noise exposure, but with a levelling off or even small declines in risk at higher noise levels. In subtype analyses, both road traffic noise and railway noise were associated with a higher risk of Alzheimer's disease, with hazard ratios of 1.16 (95% confidence interval 1.11 to 1.22) for road Ldenmax ≥65 dB compared with <45 dB, 1.27 (1.22 to 1.34) for road Ldenmin ≥55 dB compared with <40 dB, 1.16 (1.10 to 1.23) for railway Ldenmax ≥60 dB compared with <40 dB, and 1.24 (1.17 to 1.30) for railway Ldenmin ≥50 dB compared with <40 dB. Road traffic, but not railway, noise was associated with an increased risk of vascular dementia. Results indicated associations between road traffic Ldenmin and Parkinson's disease related dementia.
CONCLUSIONS: This nationwide cohort study found transportation noise to be associated with a higher risk of all cause dementia and dementia subtypes, especially Alzheimer's disease.
(Less)
- author
- publishing date
- 2021-09-08
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Aged, Causality, Dementia/epidemiology, Denmark/epidemiology, Female, Humans, Incidence, Male, Middle Aged, Noise, Transportation/adverse effects, Proportional Hazards Models, Prospective Studies, Registries
- in
- BMJ (Clinical research ed.)
- volume
- 374
- article number
- n1954
- publisher
- BMJ Publishing Group
- external identifiers
-
- scopus:85114799096
- pmid:34497091
- ISSN
- 1756-1833
- DOI
- 10.1136/bmj.n1954
- language
- English
- LU publication?
- no
- additional info
- © Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.
- id
- 2f3d4f21-1b76-4bf0-9614-686eaad82c52
- date added to LUP
- 2023-05-08 10:49:24
- date last changed
- 2024-04-19 21:35:34
@article{2f3d4f21-1b76-4bf0-9614-686eaad82c52,
abstract = {{<p>OBJECTIVE: To investigate the association between long term residential exposure to road traffic and railway noise and risk of incident dementia.</p><p>DESIGN: Nationwide prospective register based cohort study.</p><p>SETTING: Denmark.</p><p>PARTICIPANTS: 1 938 994 adults aged ≥60 years living in Denmark between 1 January 2004 and 31 December 2017.</p><p>MAIN OUTCOME MEASURES: Incident cases of all cause dementia and dementia subtypes (Alzheimer's disease, vascular dementia, and Parkinson's disease related dementia), identified from national hospital and prescription registries.</p><p>RESULTS: The study population included 103 500 participants with incident dementia, and of those, 31 219 received a diagnosis of Alzheimer's disease, 8664 of vascular dementia, and 2192 of Parkinson's disease related dementia. Using Cox regression models, 10 year mean exposure to road traffic and railway noise at the most (Ldenmax) and least (Ldenmin) exposed façades of buildings were associated with a higher risk of all cause dementia. These associations showed a general pattern of higher hazard ratios with higher noise exposure, but with a levelling off or even small declines in risk at higher noise levels. In subtype analyses, both road traffic noise and railway noise were associated with a higher risk of Alzheimer's disease, with hazard ratios of 1.16 (95% confidence interval 1.11 to 1.22) for road Ldenmax ≥65 dB compared with <45 dB, 1.27 (1.22 to 1.34) for road Ldenmin ≥55 dB compared with <40 dB, 1.16 (1.10 to 1.23) for railway Ldenmax ≥60 dB compared with <40 dB, and 1.24 (1.17 to 1.30) for railway Ldenmin ≥50 dB compared with <40 dB. Road traffic, but not railway, noise was associated with an increased risk of vascular dementia. Results indicated associations between road traffic Ldenmin and Parkinson's disease related dementia.</p><p>CONCLUSIONS: This nationwide cohort study found transportation noise to be associated with a higher risk of all cause dementia and dementia subtypes, especially Alzheimer's disease.</p>}},
author = {{Cantuaria, Manuella Lech and Waldorff, Frans Boch and Wermuth, Lene and Pedersen, Ellen Raben and Poulsen, Aslak Harbo and Thacher, Jesse Daniel and Raaschou-Nielsen, Ole and Ketzel, Matthias and Khan, Jibran and Valencia, Victor H and Schmidt, Jesper Hvass and Sørensen, Mette}},
issn = {{1756-1833}},
keywords = {{Aged; Causality; Dementia/epidemiology; Denmark/epidemiology; Female; Humans; Incidence; Male; Middle Aged; Noise, Transportation/adverse effects; Proportional Hazards Models; Prospective Studies; Registries}},
language = {{eng}},
month = {{09}},
publisher = {{BMJ Publishing Group}},
series = {{BMJ (Clinical research ed.)}},
title = {{Residential exposure to transportation noise in Denmark and incidence of dementia : national cohort study}},
url = {{http://dx.doi.org/10.1136/bmj.n1954}},
doi = {{10.1136/bmj.n1954}},
volume = {{374}},
year = {{2021}},
}