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Antioxidant secondary metabolites from Geranium lasiopus Boiss. & Heldr.

Sohretoglu, Didem; Sakar, Mahmut Koray; Sabuncuoglu, Suna Atasayar; Ozgunes, Hilal; Duman, Hayri and Sterner, Olov LU (2012) In Natural Product Research 26(13). p.1261-1264
Abstract
Chromatographic studies on the EtOAc soluble portion of the MeOH extract of Geranium lasiopus led to the isolation of eight flavonoids (kaempferol (1), quercetin (2), quercetin 3-O-beta-glucopyranoside (3), quercetin 3-O-beta-galactopyranoside (4), kaempferol 3-O-alpha-rhamnopyranosyl-(1 -> 6)-beta-glucopyranoside (5), quercetin 3-O-alpha-rhamnopyranosyl-(1 -> 6)-beta-glucopyranoside (6), kaempferol 3-O-alpha-rhamnopyranosyl-(1 -> 2)-beta-glucopyranoside (7) and quercetin 3-O-alpha-rhamnopyranosyl-(1 -> 2)-beta-glucopyranoside (8)), two simple phenolic compounds (gallic acid (9) and its methyl ester (10)) and a hydrolysable tannin (pusilagin (11)). The structures of the compounds were elucidated by 1- and 2-dimensional NMR... (More)
Chromatographic studies on the EtOAc soluble portion of the MeOH extract of Geranium lasiopus led to the isolation of eight flavonoids (kaempferol (1), quercetin (2), quercetin 3-O-beta-glucopyranoside (3), quercetin 3-O-beta-galactopyranoside (4), kaempferol 3-O-alpha-rhamnopyranosyl-(1 -> 6)-beta-glucopyranoside (5), quercetin 3-O-alpha-rhamnopyranosyl-(1 -> 6)-beta-glucopyranoside (6), kaempferol 3-O-alpha-rhamnopyranosyl-(1 -> 2)-beta-glucopyranoside (7) and quercetin 3-O-alpha-rhamnopyranosyl-(1 -> 2)-beta-glucopyranoside (8)), two simple phenolic compounds (gallic acid (9) and its methyl ester (10)) and a hydrolysable tannin (pusilagin (11)). The structures of the compounds were elucidated by 1- and 2-dimensional NMR techniques (H-1, C-13, COSY, HMBC, HMQC) and ESI-TOF-MS spectrometry. Inhibitory effects on H2O2-induced lipid peroxidation in human red blood cells of the different extracts of G. lasiopus, as well as isolated compounds, were investigated. All tested compounds showed comparable or higher activity than that of ascorbic acid and trolox. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Geranium lasiopus, Geraniaceae, flavonoids, tannin, antioxidant activity
in
Natural Product Research
volume
26
issue
13
pages
1261 - 1264
publisher
Taylor & Francis
external identifiers
  • wos:000306278100015
  • scopus:84864042894
ISSN
1478-6419
DOI
10.1080/14786419.2011.578071
language
English
LU publication?
yes
id
253a429b-1f3e-423c-9147-629860cf00d8 (old id 3001289)
date added to LUP
2012-08-21 12:58:57
date last changed
2017-03-26 03:18:05
@article{253a429b-1f3e-423c-9147-629860cf00d8,
  abstract     = {Chromatographic studies on the EtOAc soluble portion of the MeOH extract of Geranium lasiopus led to the isolation of eight flavonoids (kaempferol (1), quercetin (2), quercetin 3-O-beta-glucopyranoside (3), quercetin 3-O-beta-galactopyranoside (4), kaempferol 3-O-alpha-rhamnopyranosyl-(1 -> 6)-beta-glucopyranoside (5), quercetin 3-O-alpha-rhamnopyranosyl-(1 -> 6)-beta-glucopyranoside (6), kaempferol 3-O-alpha-rhamnopyranosyl-(1 -> 2)-beta-glucopyranoside (7) and quercetin 3-O-alpha-rhamnopyranosyl-(1 -> 2)-beta-glucopyranoside (8)), two simple phenolic compounds (gallic acid (9) and its methyl ester (10)) and a hydrolysable tannin (pusilagin (11)). The structures of the compounds were elucidated by 1- and 2-dimensional NMR techniques (H-1, C-13, COSY, HMBC, HMQC) and ESI-TOF-MS spectrometry. Inhibitory effects on H2O2-induced lipid peroxidation in human red blood cells of the different extracts of G. lasiopus, as well as isolated compounds, were investigated. All tested compounds showed comparable or higher activity than that of ascorbic acid and trolox.},
  author       = {Sohretoglu, Didem and Sakar, Mahmut Koray and Sabuncuoglu, Suna Atasayar and Ozgunes, Hilal and Duman, Hayri and Sterner, Olov},
  issn         = {1478-6419},
  keyword      = {Geranium lasiopus,Geraniaceae,flavonoids,tannin,antioxidant activity},
  language     = {eng},
  number       = {13},
  pages        = {1261--1264},
  publisher    = {Taylor & Francis},
  series       = {Natural Product Research},
  title        = {Antioxidant secondary metabolites from Geranium lasiopus Boiss. & Heldr.},
  url          = {http://dx.doi.org/10.1080/14786419.2011.578071},
  volume       = {26},
  year         = {2012},
}