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Second primary malignancies among women with uterine sarcoma

Koivisto-Korander, Riitta; Scelo, Ghislaine; Ferro, Gilles; Mellemkjaer, Lene; Hemminki, Kari LU ; Weiderpass, Elisabete; Tamaro, Sharon; Pompe-Kirn, Vera; Tracey, Elizabeth and Brewster, David H., et al. (2012) In Gynecologic Oncology 126(1). p.30-35
Abstract
Objective. Uterine sarcomas (US) are rare malignancies with unclear aetiology. Studies on uterine sarcomas in the setting of second primary malignant tumours can provide clues to aetiology and identify side effects of different treatments. Methods. A cohort of 8606 cases of US was extracted from the data from 13 cancer registries and followed for second primary cancers within the period 1943-2000. Standardized incidence ratios (SIRs) were calculated, and Poisson regression analyses were performed. Results. There were 499 cancer cases observed after a first diagnosis of US (SIR 1.26, 95%CI 1.16-1.38). SIRs were elevated for cancers of the mouth and pharynx (2.16, 95%CI 1.15-3.69), colorectum (1.60, 95%CI 1.28-1.98), lung (1.73, 95%CI... (More)
Objective. Uterine sarcomas (US) are rare malignancies with unclear aetiology. Studies on uterine sarcomas in the setting of second primary malignant tumours can provide clues to aetiology and identify side effects of different treatments. Methods. A cohort of 8606 cases of US was extracted from the data from 13 cancer registries and followed for second primary cancers within the period 1943-2000. Standardized incidence ratios (SIRs) were calculated, and Poisson regression analyses were performed. Results. There were 499 cancer cases observed after a first diagnosis of US (SIR 1.26, 95%CI 1.16-1.38). SIRs were elevated for cancers of the mouth and pharynx (2.16, 95%CI 1.15-3.69), colorectum (1.60, 95%CI 1.28-1.98), lung (1.73, 95%CI 1.27-2.29), breast (1.25, 95%CI 1.05-1.49), urinary bladder (1.74, 95%CI 1.02-2.79), kidney (2.00, 95%CI 1.24-3.06), thyroid gland (2.74, 95%CI 1.42-4.79), and soft tissue sarcoma (5.23, 95%CI 2.51-9.62). The risk of breast cancer increased along with increasing age of US diagnosis (p trend 0.040). The risk of kidney cancer increased along with decreasing age of US diagnosis (p trend 0.004) and short time since the US diagnosis (p trend 0.018). Conclusions. Our study demonstrated increased risk of certain cancers following a diagnosis of US. The elevated risk for breast cancer may indicate shared hormonal aetiology, while the increased risk of colorectal and bladder cancers after US may be caused by radiation therapy of US. The clustering of smoking-related cancers after US is worth exploring in the future. (c) 2012 Elsevier Inc. All rights reserved. (Less)
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published
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keywords
Uterine sarcoma, Endometrial stromal sarcoma, Uterine leiomyosarcoma, Second primary cancer, Multi-centre cohort study
in
Gynecologic Oncology
volume
126
issue
1
pages
30 - 35
publisher
Academic Press
external identifiers
  • wos:000305878400007
  • scopus:84862765844
ISSN
1095-6859
DOI
10.1016/j.ygyno.2012.04.002
language
English
LU publication?
yes
id
d2cb984f-caeb-4bb6-8a49-9b2f62f7a374 (old id 3001465)
date added to LUP
2012-09-03 07:20:13
date last changed
2017-01-01 04:02:27
@article{d2cb984f-caeb-4bb6-8a49-9b2f62f7a374,
  abstract     = {Objective. Uterine sarcomas (US) are rare malignancies with unclear aetiology. Studies on uterine sarcomas in the setting of second primary malignant tumours can provide clues to aetiology and identify side effects of different treatments. Methods. A cohort of 8606 cases of US was extracted from the data from 13 cancer registries and followed for second primary cancers within the period 1943-2000. Standardized incidence ratios (SIRs) were calculated, and Poisson regression analyses were performed. Results. There were 499 cancer cases observed after a first diagnosis of US (SIR 1.26, 95%CI 1.16-1.38). SIRs were elevated for cancers of the mouth and pharynx (2.16, 95%CI 1.15-3.69), colorectum (1.60, 95%CI 1.28-1.98), lung (1.73, 95%CI 1.27-2.29), breast (1.25, 95%CI 1.05-1.49), urinary bladder (1.74, 95%CI 1.02-2.79), kidney (2.00, 95%CI 1.24-3.06), thyroid gland (2.74, 95%CI 1.42-4.79), and soft tissue sarcoma (5.23, 95%CI 2.51-9.62). The risk of breast cancer increased along with increasing age of US diagnosis (p trend 0.040). The risk of kidney cancer increased along with decreasing age of US diagnosis (p trend 0.004) and short time since the US diagnosis (p trend 0.018). Conclusions. Our study demonstrated increased risk of certain cancers following a diagnosis of US. The elevated risk for breast cancer may indicate shared hormonal aetiology, while the increased risk of colorectal and bladder cancers after US may be caused by radiation therapy of US. The clustering of smoking-related cancers after US is worth exploring in the future. (c) 2012 Elsevier Inc. All rights reserved.},
  author       = {Koivisto-Korander, Riitta and Scelo, Ghislaine and Ferro, Gilles and Mellemkjaer, Lene and Hemminki, Kari and Weiderpass, Elisabete and Tamaro, Sharon and Pompe-Kirn, Vera and Tracey, Elizabeth and Brewster, David H. and Kliewer, Erich V. and Tonita, Jon M. and Kee-Seng, Chia and Jonasson, Jon G. and Martos, Carmen and Brennan, Paul and Straif, Kurt and Pukkala, Eero},
  issn         = {1095-6859},
  keyword      = {Uterine sarcoma,Endometrial stromal sarcoma,Uterine leiomyosarcoma,Second primary cancer,Multi-centre cohort study},
  language     = {eng},
  number       = {1},
  pages        = {30--35},
  publisher    = {Academic Press},
  series       = {Gynecologic Oncology},
  title        = {Second primary malignancies among women with uterine sarcoma},
  url          = {http://dx.doi.org/10.1016/j.ygyno.2012.04.002},
  volume       = {126},
  year         = {2012},
}