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Familial colorectal adenocarcinoma and hereditary nonpolyposis colorectal cancer : a nationwide epidemiological study from Sweden

Hemminki, K LU and Li, Xinjun LU (2001) In British Journal of Cancer 84(7). p.74-969
Abstract

Although estimates are available of the proportion of hereditary nonpolyposis colorectal cancer (HNPCC) among all colorectal cancer (CRC), its proportion among familial CRC is unclear. We estimated these proportions epidemiologically from the nationwide Swedish Family-Cancer Database on 9.6 million individuals. Colorectal adenocarcinomas were retrieved from the Cancer Registry covering years 1958-1996. Standardized incidence ratios (SIRs) were calculated for offspring (aged less than 62 years) when their parent had colorectal adenocarcinoma. In 9.82% of all families, an offspring and a parent were affected, giving a population attributable proportion of 4.91% and a familial SIR of 2.00. When offspring and parents shared the anatomic... (More)

Although estimates are available of the proportion of hereditary nonpolyposis colorectal cancer (HNPCC) among all colorectal cancer (CRC), its proportion among familial CRC is unclear. We estimated these proportions epidemiologically from the nationwide Swedish Family-Cancer Database on 9.6 million individuals. Colorectal adenocarcinomas were retrieved from the Cancer Registry covering years 1958-1996. Standardized incidence ratios (SIRs) were calculated for offspring (aged less than 62 years) when their parent had colorectal adenocarcinoma. In 9.82% of all families, an offspring and a parent were affected, giving a population attributable proportion of 4.91% and a familial SIR of 2.00. When offspring and parents shared the anatomic site, the SIR was 2.32 for proximal and 2.00 for distal CRC. When offspring were diagnosed before age 40 years and parents before age 50 years, the SIR was 25.72 for familial proximal CRC. In older age groups familial risks did not differ between proximal and distal CRC. Familial risks were increased also for endometrial, small intestinal and gastric cancers, manifestations in HNPCC. Depending on which assumptions were made, HNPCC was calculated to account for 20 to 50% of familial CRC, corresponding to 1 or 2.5% of all CRC among 0-61-year-old individuals.

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author
publishing date
type
Contribution to journal
publication status
published
keywords
Adenocarcinoma/epidemiology, Adult, Colorectal Neoplasms/epidemiology, Colorectal Neoplasms, Hereditary Nonpolyposis/epidemiology, Family Health, Female, Humans, Male, Middle Aged, Registries, Sweden/epidemiology
in
British Journal of Cancer
volume
84
issue
7
pages
74 - 969
publisher
Nature Publishing Group
external identifiers
  • scopus:0035815223
ISSN
0007-0920
DOI
10.1054/bjoc.2000.1718
language
English
LU publication?
no
id
3002a9cf-96ee-4b42-bebe-04870f33e1e7
date added to LUP
2019-01-30 12:17:04
date last changed
2019-03-05 04:31:21
@article{3002a9cf-96ee-4b42-bebe-04870f33e1e7,
  abstract     = {<p>Although estimates are available of the proportion of hereditary nonpolyposis colorectal cancer (HNPCC) among all colorectal cancer (CRC), its proportion among familial CRC is unclear. We estimated these proportions epidemiologically from the nationwide Swedish Family-Cancer Database on 9.6 million individuals. Colorectal adenocarcinomas were retrieved from the Cancer Registry covering years 1958-1996. Standardized incidence ratios (SIRs) were calculated for offspring (aged less than 62 years) when their parent had colorectal adenocarcinoma. In 9.82% of all families, an offspring and a parent were affected, giving a population attributable proportion of 4.91% and a familial SIR of 2.00. When offspring and parents shared the anatomic site, the SIR was 2.32 for proximal and 2.00 for distal CRC. When offspring were diagnosed before age 40 years and parents before age 50 years, the SIR was 25.72 for familial proximal CRC. In older age groups familial risks did not differ between proximal and distal CRC. Familial risks were increased also for endometrial, small intestinal and gastric cancers, manifestations in HNPCC. Depending on which assumptions were made, HNPCC was calculated to account for 20 to 50% of familial CRC, corresponding to 1 or 2.5% of all CRC among 0-61-year-old individuals.</p>},
  author       = {Hemminki, K and Li, Xinjun},
  issn         = {0007-0920},
  keyword      = {Adenocarcinoma/epidemiology,Adult,Colorectal Neoplasms/epidemiology,Colorectal Neoplasms, Hereditary Nonpolyposis/epidemiology,Family Health,Female,Humans,Male,Middle Aged,Registries,Sweden/epidemiology},
  language     = {eng},
  month        = {04},
  number       = {7},
  pages        = {74--969},
  publisher    = {Nature Publishing Group},
  series       = {British Journal of Cancer},
  title        = {Familial colorectal adenocarcinoma and hereditary nonpolyposis colorectal cancer : a nationwide epidemiological study from Sweden},
  url          = {http://dx.doi.org/10.1054/bjoc.2000.1718},
  volume       = {84},
  year         = {2001},
}