A population-based study of the outcome for patients with first relapse of Hodgkin's lymphoma
(2002) In European Journal of Haematology 68(4). p.225-232- Abstract
- Background : Our aims were to evaluate the response to salvage treatment in relation to initial treatment and to evaluate prognostic factors at the time of relapse in an unselected population of relapsing patients with Hodgkin's lymphoma (HL). Patients and methods: In total, 124 patients younger than 60 yr of age with initial diagnosis of HL in Sweden relapsed between 1985 and 1995. Results : Fifty-eight patients relapsed after initial treatment with radiotherapy (RT) only, 62 after combination chemotherapy (CT), of whom 30 had received additional involved-field RT, and four after a short course of CT followed by extended-field RT. For 37 patients among the 58 relapsers after initial RT treated according to the recommendations of the... (More)
- Background : Our aims were to evaluate the response to salvage treatment in relation to initial treatment and to evaluate prognostic factors at the time of relapse in an unselected population of relapsing patients with Hodgkin's lymphoma (HL). Patients and methods: In total, 124 patients younger than 60 yr of age with initial diagnosis of HL in Sweden relapsed between 1985 and 1995. Results : Fifty-eight patients relapsed after initial treatment with radiotherapy (RT) only, 62 after combination chemotherapy (CT), of whom 30 had received additional involved-field RT, and four after a short course of CT followed by extended-field RT. For 37 patients among the 58 relapsers after initial RT treated according to the recommendations of the National guidelines, the 5-yr Hodgkin-specific survival (HLS) was 85%, overall survival (OS) 73% and event-free survival (EFS) 62%, which is not inferior to survival in patients with primarily advanced stages. It was poorer in the 21 patients who initially had received RT only, even though they had been recommended for more extensive treatment. For patients initially treated with a full course (6-8 cycles) of CT the 5-yr HLS was 60%, OS 58% and EFS 22%. Bulky disease and age at diagnosis strongly affected survival in a multivariate analysis. Conclusions: Patients initially treated with RT who relapse have a favourable outcome, provided they have been treated according to the recommendations of the guidelines at the time of diagnosis. Initially bulky disease and, as a consequence, additional RT as part of the initial treatment negatively affect survival at relapse in patients initially treated with a full course of CT. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/334548
- author
- Amini, RM ; Glimelius, B ; Gustavsson, Anita LU ; Ekman, T ; Erlanson, M ; Haapaniemi, E and Enblad, G
- organization
- publishing date
- 2002
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- treatment, relapse, Hodgkin's lymphoma, prognostic factors
- in
- European Journal of Haematology
- volume
- 68
- issue
- 4
- pages
- 225 - 232
- publisher
- Wiley-Blackwell
- external identifiers
-
- pmid:12071938
- wos:000176473000006
- scopus:0036288749
- ISSN
- 1600-0609
- DOI
- 10.1034/j.1600-0609.2002.01565.x
- language
- English
- LU publication?
- yes
- id
- 3010afa6-1ab6-45ce-861c-756f13257d4e (old id 334548)
- date added to LUP
- 2016-04-01 11:41:56
- date last changed
- 2022-01-26 08:56:02
@article{3010afa6-1ab6-45ce-861c-756f13257d4e,
abstract = {{Background : Our aims were to evaluate the response to salvage treatment in relation to initial treatment and to evaluate prognostic factors at the time of relapse in an unselected population of relapsing patients with Hodgkin's lymphoma (HL). Patients and methods: In total, 124 patients younger than 60 yr of age with initial diagnosis of HL in Sweden relapsed between 1985 and 1995. Results : Fifty-eight patients relapsed after initial treatment with radiotherapy (RT) only, 62 after combination chemotherapy (CT), of whom 30 had received additional involved-field RT, and four after a short course of CT followed by extended-field RT. For 37 patients among the 58 relapsers after initial RT treated according to the recommendations of the National guidelines, the 5-yr Hodgkin-specific survival (HLS) was 85%, overall survival (OS) 73% and event-free survival (EFS) 62%, which is not inferior to survival in patients with primarily advanced stages. It was poorer in the 21 patients who initially had received RT only, even though they had been recommended for more extensive treatment. For patients initially treated with a full course (6-8 cycles) of CT the 5-yr HLS was 60%, OS 58% and EFS 22%. Bulky disease and age at diagnosis strongly affected survival in a multivariate analysis. Conclusions: Patients initially treated with RT who relapse have a favourable outcome, provided they have been treated according to the recommendations of the guidelines at the time of diagnosis. Initially bulky disease and, as a consequence, additional RT as part of the initial treatment negatively affect survival at relapse in patients initially treated with a full course of CT.}},
author = {{Amini, RM and Glimelius, B and Gustavsson, Anita and Ekman, T and Erlanson, M and Haapaniemi, E and Enblad, G}},
issn = {{1600-0609}},
keywords = {{treatment; relapse; Hodgkin's lymphoma; prognostic factors}},
language = {{eng}},
number = {{4}},
pages = {{225--232}},
publisher = {{Wiley-Blackwell}},
series = {{European Journal of Haematology}},
title = {{A population-based study of the outcome for patients with first relapse of Hodgkin's lymphoma}},
url = {{http://dx.doi.org/10.1034/j.1600-0609.2002.01565.x}},
doi = {{10.1034/j.1600-0609.2002.01565.x}},
volume = {{68}},
year = {{2002}},
}