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A prospective study of different types of hormone replacement therapy use and the risk of subsequent breast cancer: the women's health in the Lund area (WHILA) study (Sweden)

Jernström, Helena LU ; Bendahl, Pär-Ola LU ; Lidfeldt, Jonas LU ; Nerbrand, Christina LU ; Agardh, Carl-David LU and Samsioe, Göran LU (2003) In Cancer Causes and Control 14(7). p.673-680
Abstract
Objectives: Reports suggest that combined estrogen plus progestin hormone replacement therapy (HRT) confers a higher breast cancer risk than estrogen alone. We aimed to establish whether breast cancer risk depends on the type of HRT formula. Methods: The cohort consisted of 6586 women, aged 50 - 64 years, from the Lund area, Sweden, with no reported breast cancer upon inclusion. We obtained information such as HRT use through a questionnaire between December 1995 and February 2000. New breast cancers were identified through the South Swedish tumor registry. Results: Between inclusion and December 2001, 101 women developed breast cancer. Only ever use of the continuous combined estrogen plus progestin ( CCEP) formula differed between cases... (More)
Objectives: Reports suggest that combined estrogen plus progestin hormone replacement therapy (HRT) confers a higher breast cancer risk than estrogen alone. We aimed to establish whether breast cancer risk depends on the type of HRT formula. Methods: The cohort consisted of 6586 women, aged 50 - 64 years, from the Lund area, Sweden, with no reported breast cancer upon inclusion. We obtained information such as HRT use through a questionnaire between December 1995 and February 2000. New breast cancers were identified through the South Swedish tumor registry. Results: Between inclusion and December 2001, 101 women developed breast cancer. Only ever use of the continuous combined estrogen plus progestin ( CCEP) formula differed between cases and controls (45.2% versus 23.5%; p = 0.000001). Compared with never users, exclusive CCEP users had the highest age-adjusted hazard ratio HR 3.3 (95% CI: 1.9 - 5.6; p < 0.001), followed by users of CCEP in addition to other HRT formulas HR 2.8 (95% CI: 1.4 - 5.5; p = 0.003). No significant increase was seen in women who exclusively used other HRT formulas. Conclusion: Women who used CCEP had over three times the risk of developing breast cancer compared with never users and twice the risk compared with users of other types of HRT. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
hormone replacement therapy, estrogen, breast neoplasm, cohort study, progestin
in
Cancer Causes and Control
volume
14
issue
7
pages
673 - 680
publisher
Springer
external identifiers
  • wos:000185261300009
  • pmid:14575365
  • scopus:0141639805
ISSN
1573-7225
DOI
10.1023/A:1025635720208
language
English
LU publication?
yes
id
f750d13e-8dda-43ae-917d-eb79d117c2b9 (old id 301397)
date added to LUP
2007-08-03 11:17:08
date last changed
2018-10-04 13:36:05
@article{f750d13e-8dda-43ae-917d-eb79d117c2b9,
  abstract     = {Objectives: Reports suggest that combined estrogen plus progestin hormone replacement therapy (HRT) confers a higher breast cancer risk than estrogen alone. We aimed to establish whether breast cancer risk depends on the type of HRT formula. Methods: The cohort consisted of 6586 women, aged 50 - 64 years, from the Lund area, Sweden, with no reported breast cancer upon inclusion. We obtained information such as HRT use through a questionnaire between December 1995 and February 2000. New breast cancers were identified through the South Swedish tumor registry. Results: Between inclusion and December 2001, 101 women developed breast cancer. Only ever use of the continuous combined estrogen plus progestin ( CCEP) formula differed between cases and controls (45.2% versus 23.5%; p = 0.000001). Compared with never users, exclusive CCEP users had the highest age-adjusted hazard ratio HR 3.3 (95% CI: 1.9 - 5.6; p &lt; 0.001), followed by users of CCEP in addition to other HRT formulas HR 2.8 (95% CI: 1.4 - 5.5; p = 0.003). No significant increase was seen in women who exclusively used other HRT formulas. Conclusion: Women who used CCEP had over three times the risk of developing breast cancer compared with never users and twice the risk compared with users of other types of HRT.},
  author       = {Jernström, Helena and Bendahl, Pär-Ola and Lidfeldt, Jonas and Nerbrand, Christina and Agardh, Carl-David and Samsioe, Göran},
  issn         = {1573-7225},
  keyword      = {hormone replacement therapy,estrogen,breast neoplasm,cohort study,progestin},
  language     = {eng},
  number       = {7},
  pages        = {673--680},
  publisher    = {Springer},
  series       = {Cancer Causes and Control},
  title        = {A prospective study of different types of hormone replacement therapy use and the risk of subsequent breast cancer: the women's health in the Lund area (WHILA) study (Sweden)},
  url          = {http://dx.doi.org/10.1023/A:1025635720208},
  volume       = {14},
  year         = {2003},
}