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Genistein as an anti-inflammatory agent

Verdrengh, M; Jonsson, IM; Holmdahl, Rikard LU and Tarkowski, A (2003) In Inflammation Research1995-01-01+01:00 52(8). p.341-346
Abstract
Objective and design: The aim of this study was to investigate the impact of the isoflavone genistein on in vivo cell-mediated responses. In addition, we wanted to study the influence of genistein on collagen induced arthritis (CIA) in mice. Methods: Delayed type hypersensitivity reaction (DTH) to oxazolone and the inflammatory response to olive oil were measured in mice treated with genistein. In addition, the impact of genistein treatment on disease progression and outcome of collagen induced arthritis (CIA) was examined. Results: The DTH reaction to oxazolone and the granulocyte-mediated response were significantly suppressed in genistein-treated as compared to control mice. Also, genistein treatment led to decreased levels of... (More)
Objective and design: The aim of this study was to investigate the impact of the isoflavone genistein on in vivo cell-mediated responses. In addition, we wanted to study the influence of genistein on collagen induced arthritis (CIA) in mice. Methods: Delayed type hypersensitivity reaction (DTH) to oxazolone and the inflammatory response to olive oil were measured in mice treated with genistein. In addition, the impact of genistein treatment on disease progression and outcome of collagen induced arthritis (CIA) was examined. Results: The DTH reaction to oxazolone and the granulocyte-mediated response were significantly suppressed in genistein-treated as compared to control mice. Also, genistein treatment led to decreased levels of oxazolone-specific antibodies. Histologically, mice exposed to genistein and immunized with collagen II displayed somewhat lower degree of inflammation and joint destruction. In addition, serum levels of autoantibodies to collagen II were significantly lower following genistein-treatment in immunized mice. Conclusion: We conclude that genistein exerts evident anti-inflammatory properties affecting granulocytes, monocytes, and lymphocytes. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
delayed type, lymphocytes, collagen induced arthritis, granulocytes, hypersensitivity reaction
in
Inflammation Research1995-01-01+01:00
volume
52
issue
8
pages
341 - 346
publisher
Birkhaüser
external identifiers
  • pmid:14504672
  • wos:000184984000004
  • scopus:0041661977
ISSN
1420-908X
DOI
10.1007/s00011-003-1182-8
language
English
LU publication?
yes
id
1cb19869-a3c3-4a43-83c9-9373ea3ac131 (old id 302275)
date added to LUP
2007-09-23 13:53:05
date last changed
2018-09-30 03:30:38
@article{1cb19869-a3c3-4a43-83c9-9373ea3ac131,
  abstract     = {Objective and design: The aim of this study was to investigate the impact of the isoflavone genistein on in vivo cell-mediated responses. In addition, we wanted to study the influence of genistein on collagen induced arthritis (CIA) in mice. Methods: Delayed type hypersensitivity reaction (DTH) to oxazolone and the inflammatory response to olive oil were measured in mice treated with genistein. In addition, the impact of genistein treatment on disease progression and outcome of collagen induced arthritis (CIA) was examined. Results: The DTH reaction to oxazolone and the granulocyte-mediated response were significantly suppressed in genistein-treated as compared to control mice. Also, genistein treatment led to decreased levels of oxazolone-specific antibodies. Histologically, mice exposed to genistein and immunized with collagen II displayed somewhat lower degree of inflammation and joint destruction. In addition, serum levels of autoantibodies to collagen II were significantly lower following genistein-treatment in immunized mice. Conclusion: We conclude that genistein exerts evident anti-inflammatory properties affecting granulocytes, monocytes, and lymphocytes.},
  author       = {Verdrengh, M and Jonsson, IM and Holmdahl, Rikard and Tarkowski, A},
  issn         = {1420-908X},
  keyword      = {delayed type,lymphocytes,collagen induced arthritis,granulocytes,hypersensitivity reaction},
  language     = {eng},
  number       = {8},
  pages        = {341--346},
  publisher    = {Birkhaüser},
  series       = {Inflammation Research1995-01-01+01:00},
  title        = {Genistein as an anti-inflammatory agent},
  url          = {http://dx.doi.org/10.1007/s00011-003-1182-8},
  volume       = {52},
  year         = {2003},
}