Evidence for Prepulse Inhibition of Visually Evoked Motor Response in Drosophila melanogaster
(2023) In Biology 12(4).- Abstract
Prepulse inhibition (PPI) is a widely investigated behavior to study the mechanisms of disorders such as anxiety, schizophrenia, and bipolar mania. PPI has been observed across various vertebrate and invertebrate species; however, it has not yet been reported in adult Drosophila melanogaster. In this study, we describe the first detection of PPI of visually evoked locomotor arousal in flies. To validate our findings, we demonstrate that PPI in Drosophila can be partially reverted by the N-methyl D-aspartate (NMDA) receptor antagonist MK-801, known for inducing sensorimotor gating deficits in rodent models. Additionally, we show that the visually evoked response can be inhibited by multiple stimuli presentation, which can also be... (More)
Prepulse inhibition (PPI) is a widely investigated behavior to study the mechanisms of disorders such as anxiety, schizophrenia, and bipolar mania. PPI has been observed across various vertebrate and invertebrate species; however, it has not yet been reported in adult Drosophila melanogaster. In this study, we describe the first detection of PPI of visually evoked locomotor arousal in flies. To validate our findings, we demonstrate that PPI in Drosophila can be partially reverted by the N-methyl D-aspartate (NMDA) receptor antagonist MK-801, known for inducing sensorimotor gating deficits in rodent models. Additionally, we show that the visually evoked response can be inhibited by multiple stimuli presentation, which can also be affected by MK-801. Given the versatility of Drosophila as a model organism for genetic screening and analysis, our results suggest that high-throughput behavioral screenings of adult flies can become a valuable tool for investigating the mechanisms behind PPI.
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- author
- Schiöth, Helgi B. ; Donzelli, Laura ; Arvidsson, Nicklas ; Williams, Michael J. and Moulin, Thiago C. LU
- organization
- publishing date
- 2023
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- anxiety, dizocilpine, Drosophila melanogaster, escape response, invertebrates, prepulse inhibition (PPI), schizophrenia, sensorimotor gating, startle
- in
- Biology
- volume
- 12
- issue
- 4
- article number
- 635
- publisher
- MDPI AG
- external identifiers
-
- pmid:37106835
- scopus:85154040780
- ISSN
- 2079-7737
- DOI
- 10.3390/biology12040635
- language
- English
- LU publication?
- yes
- id
- 3028266c-4643-43cb-9eb7-7aeb9fd21269
- date added to LUP
- 2023-07-14 09:23:58
- date last changed
- 2024-04-19 23:25:34
@article{3028266c-4643-43cb-9eb7-7aeb9fd21269,
abstract = {{<p>Prepulse inhibition (PPI) is a widely investigated behavior to study the mechanisms of disorders such as anxiety, schizophrenia, and bipolar mania. PPI has been observed across various vertebrate and invertebrate species; however, it has not yet been reported in adult Drosophila melanogaster. In this study, we describe the first detection of PPI of visually evoked locomotor arousal in flies. To validate our findings, we demonstrate that PPI in Drosophila can be partially reverted by the N-methyl D-aspartate (NMDA) receptor antagonist MK-801, known for inducing sensorimotor gating deficits in rodent models. Additionally, we show that the visually evoked response can be inhibited by multiple stimuli presentation, which can also be affected by MK-801. Given the versatility of Drosophila as a model organism for genetic screening and analysis, our results suggest that high-throughput behavioral screenings of adult flies can become a valuable tool for investigating the mechanisms behind PPI.</p>}},
author = {{Schiöth, Helgi B. and Donzelli, Laura and Arvidsson, Nicklas and Williams, Michael J. and Moulin, Thiago C.}},
issn = {{2079-7737}},
keywords = {{anxiety; dizocilpine; Drosophila melanogaster; escape response; invertebrates; prepulse inhibition (PPI); schizophrenia; sensorimotor gating; startle}},
language = {{eng}},
number = {{4}},
publisher = {{MDPI AG}},
series = {{Biology}},
title = {{Evidence for Prepulse Inhibition of Visually Evoked Motor Response in Drosophila melanogaster}},
url = {{http://dx.doi.org/10.3390/biology12040635}},
doi = {{10.3390/biology12040635}},
volume = {{12}},
year = {{2023}},
}