Cerebral pattern of pro- and anti-inflammatory cytokines in dementias
(2003) In Brain Research Bulletin 61(3). p.255-260- Abstract
- The knowledge regarding putative inflammatory component(s) participating in Alzheimer's disease (AD) and vascular dementia (VAD) is scarce. Recently, we have demonstrated the presence of certain inflammatory cytokines in the cerebrospinal fluid (CSF) of demented patients. Although the initial event(s) triggering the neurodegenerative processes in AD versus VAD may be different and lead to different neuropathological changes, it may initiate a similar cascade of cytokine production in response to neuronal injury. The cytokines released in the central nervous system (CNS) may, in turn, act in a similar manner in both diseases, amplifying some pathological changes such as amyloidogenesis and white matter lesions or on the contrary acting as... (More)
- The knowledge regarding putative inflammatory component(s) participating in Alzheimer's disease (AD) and vascular dementia (VAD) is scarce. Recently, we have demonstrated the presence of certain inflammatory cytokines in the cerebrospinal fluid (CSF) of demented patients. Although the initial event(s) triggering the neurodegenerative processes in AD versus VAD may be different and lead to different neuropathological changes, it may initiate a similar cascade of cytokine production in response to neuronal injury. The cytokines released in the central nervous system (CNS) may, in turn, act in a similar manner in both diseases, amplifying some pathological changes such as amyloidogenesis and white matter lesions or on the contrary acting as neuroprotective molecules. This review will focus on the intracerebral production of the pro- and anti-inflammatory cytokines interleukin IL-1beta, IL-1 receptor antagonist (IL-1ra), IL-6 and TNF-alpha in dementia, and their relation to gene polymorphism, to cerebral neuronal damage, apoptosis, and to clinical variables of dementia. Our results, which show for the first time strikingly increased CSF levels of TNF-alpha but not of TNF-beta, IL-1beta or IL-6 in AD and VAD, may form a conceptual framework for further studies of neuroprotective mechanisms in dementias. (C) 2003 Elsevier Science Inc. All rights reserved. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/303617
- author
- Tarkowski, E ; Liljeroth, AM ; Minthon, Lennart LU ; Tarkowski, A ; Wallin, A and Blennow, K
- organization
- publishing date
- 2003
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- apoptosis, cytokines, gene polymorphism, dementia
- in
- Brain Research Bulletin
- volume
- 61
- issue
- 3
- pages
- 255 - 260
- publisher
- Elsevier
- external identifiers
-
- pmid:12909295
- wos:000184879800005
- scopus:0043092058
- ISSN
- 0361-9230
- DOI
- 10.1016/S0361-9230(03)00088-1
- language
- English
- LU publication?
- yes
- id
- e40edb5c-307a-4b03-bfdf-064800bbc786 (old id 303617)
- date added to LUP
- 2016-04-01 11:58:57
- date last changed
- 2022-03-28 18:33:56
@article{e40edb5c-307a-4b03-bfdf-064800bbc786,
abstract = {{The knowledge regarding putative inflammatory component(s) participating in Alzheimer's disease (AD) and vascular dementia (VAD) is scarce. Recently, we have demonstrated the presence of certain inflammatory cytokines in the cerebrospinal fluid (CSF) of demented patients. Although the initial event(s) triggering the neurodegenerative processes in AD versus VAD may be different and lead to different neuropathological changes, it may initiate a similar cascade of cytokine production in response to neuronal injury. The cytokines released in the central nervous system (CNS) may, in turn, act in a similar manner in both diseases, amplifying some pathological changes such as amyloidogenesis and white matter lesions or on the contrary acting as neuroprotective molecules. This review will focus on the intracerebral production of the pro- and anti-inflammatory cytokines interleukin IL-1beta, IL-1 receptor antagonist (IL-1ra), IL-6 and TNF-alpha in dementia, and their relation to gene polymorphism, to cerebral neuronal damage, apoptosis, and to clinical variables of dementia. Our results, which show for the first time strikingly increased CSF levels of TNF-alpha but not of TNF-beta, IL-1beta or IL-6 in AD and VAD, may form a conceptual framework for further studies of neuroprotective mechanisms in dementias. (C) 2003 Elsevier Science Inc. All rights reserved.}},
author = {{Tarkowski, E and Liljeroth, AM and Minthon, Lennart and Tarkowski, A and Wallin, A and Blennow, K}},
issn = {{0361-9230}},
keywords = {{apoptosis; cytokines; gene polymorphism; dementia}},
language = {{eng}},
number = {{3}},
pages = {{255--260}},
publisher = {{Elsevier}},
series = {{Brain Research Bulletin}},
title = {{Cerebral pattern of pro- and anti-inflammatory cytokines in dementias}},
url = {{http://dx.doi.org/10.1016/S0361-9230(03)00088-1}},
doi = {{10.1016/S0361-9230(03)00088-1}},
volume = {{61}},
year = {{2003}},
}