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Cerebral pattern of pro- and anti-inflammatory cytokines in dementias

Tarkowski, E; Liljeroth, AM; Minthon, Lennart LU ; Tarkowski, A; Wallin, A and Blennow, K (2003) In Brain Research Bulletin 61(3). p.255-260
Abstract
The knowledge regarding putative inflammatory component(s) participating in Alzheimer's disease (AD) and vascular dementia (VAD) is scarce. Recently, we have demonstrated the presence of certain inflammatory cytokines in the cerebrospinal fluid (CSF) of demented patients. Although the initial event(s) triggering the neurodegenerative processes in AD versus VAD may be different and lead to different neuropathological changes, it may initiate a similar cascade of cytokine production in response to neuronal injury. The cytokines released in the central nervous system (CNS) may, in turn, act in a similar manner in both diseases, amplifying some pathological changes such as amyloidogenesis and white matter lesions or on the contrary acting as... (More)
The knowledge regarding putative inflammatory component(s) participating in Alzheimer's disease (AD) and vascular dementia (VAD) is scarce. Recently, we have demonstrated the presence of certain inflammatory cytokines in the cerebrospinal fluid (CSF) of demented patients. Although the initial event(s) triggering the neurodegenerative processes in AD versus VAD may be different and lead to different neuropathological changes, it may initiate a similar cascade of cytokine production in response to neuronal injury. The cytokines released in the central nervous system (CNS) may, in turn, act in a similar manner in both diseases, amplifying some pathological changes such as amyloidogenesis and white matter lesions or on the contrary acting as neuroprotective molecules. This review will focus on the intracerebral production of the pro- and anti-inflammatory cytokines interleukin IL-1beta, IL-1 receptor antagonist (IL-1ra), IL-6 and TNF-alpha in dementia, and their relation to gene polymorphism, to cerebral neuronal damage, apoptosis, and to clinical variables of dementia. Our results, which show for the first time strikingly increased CSF levels of TNF-alpha but not of TNF-beta, IL-1beta or IL-6 in AD and VAD, may form a conceptual framework for further studies of neuroprotective mechanisms in dementias. (C) 2003 Elsevier Science Inc. All rights reserved. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
apoptosis, cytokines, gene polymorphism, dementia
in
Brain Research Bulletin
volume
61
issue
3
pages
255 - 260
publisher
Elsevier
external identifiers
  • pmid:12909295
  • wos:000184879800005
  • scopus:0043092058
ISSN
0361-9230
DOI
language
English
LU publication?
yes
id
e40edb5c-307a-4b03-bfdf-064800bbc786 (old id 303617)
date added to LUP
2007-09-23 10:23:13
date last changed
2018-05-29 11:44:35
@article{e40edb5c-307a-4b03-bfdf-064800bbc786,
  abstract     = {The knowledge regarding putative inflammatory component(s) participating in Alzheimer's disease (AD) and vascular dementia (VAD) is scarce. Recently, we have demonstrated the presence of certain inflammatory cytokines in the cerebrospinal fluid (CSF) of demented patients. Although the initial event(s) triggering the neurodegenerative processes in AD versus VAD may be different and lead to different neuropathological changes, it may initiate a similar cascade of cytokine production in response to neuronal injury. The cytokines released in the central nervous system (CNS) may, in turn, act in a similar manner in both diseases, amplifying some pathological changes such as amyloidogenesis and white matter lesions or on the contrary acting as neuroprotective molecules. This review will focus on the intracerebral production of the pro- and anti-inflammatory cytokines interleukin IL-1beta, IL-1 receptor antagonist (IL-1ra), IL-6 and TNF-alpha in dementia, and their relation to gene polymorphism, to cerebral neuronal damage, apoptosis, and to clinical variables of dementia. Our results, which show for the first time strikingly increased CSF levels of TNF-alpha but not of TNF-beta, IL-1beta or IL-6 in AD and VAD, may form a conceptual framework for further studies of neuroprotective mechanisms in dementias. (C) 2003 Elsevier Science Inc. All rights reserved.},
  author       = {Tarkowski, E and Liljeroth, AM and Minthon, Lennart and Tarkowski, A and Wallin, A and Blennow, K},
  issn         = {0361-9230},
  keyword      = {apoptosis,cytokines,gene polymorphism,dementia},
  language     = {eng},
  number       = {3},
  pages        = {255--260},
  publisher    = {Elsevier},
  series       = {Brain Research Bulletin},
  title        = {Cerebral pattern of pro- and anti-inflammatory cytokines in dementias},
  url          = {http://dx.doi.org/},
  volume       = {61},
  year         = {2003},
}