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Measurements of medial temporal lobe atrophy for prediction of Alzheimer's disease in subjects with mild cognitive impairment

Clerx, Lies; van Rossum, Ineke A.; Burns, Leah; Knol, Dirk L.; Scheltens, Philip; Verhey, Frans; Aalten, Pauline; Lapuerta, Pablo; van de Pol, Laura and van Schijndel, Ronald, et al. (2013) In Neurobiology of Aging 34(8). p.2003-2013
Abstract
Our aim was to compare the predictive accuracy of 4 different medial temporal lobe measurements for Alzheimer's disease (AD) in subjects with mild cognitive impairment (MCI). Manual hippocampal measurement, automated atlas-based hippocampal measurement, a visual rating scale (MTA-score), and lateral ventricle measurement were compared. Predictive accuracy for AD 2 years after baseline was assessed by receiver operating characteristics analyses with area under the curve as outcome. Annual cognitive decline was assessed by slope analyses up to 5 years after baseline. Correlations with biomarkers in cerebrospinal fluid (CSF) were investigated. Subjects with MCI were selected from the Development of Screening Guidelines and Clinical Criteria... (More)
Our aim was to compare the predictive accuracy of 4 different medial temporal lobe measurements for Alzheimer's disease (AD) in subjects with mild cognitive impairment (MCI). Manual hippocampal measurement, automated atlas-based hippocampal measurement, a visual rating scale (MTA-score), and lateral ventricle measurement were compared. Predictive accuracy for AD 2 years after baseline was assessed by receiver operating characteristics analyses with area under the curve as outcome. Annual cognitive decline was assessed by slope analyses up to 5 years after baseline. Correlations with biomarkers in cerebrospinal fluid (CSF) were investigated. Subjects with MCI were selected from the Development of Screening Guidelines and Clinical Criteria for Predementia AD (DESCRIPA) multicenter study (n = 156) and the single-center VU medical center (n = 172). At follow-up, area under the curve was highest for automated atlas-based hippocampal measurement (0.71) and manual hippocampal measurement (0.71), and lower for MTA-score (0.65) and lateral ventricle (0.60). Slope analysis yielded similar results. Hippocampal measurements correlated with CSF total tau and phosphorylated tau, not with beta-amyloid 1-42. MTA-score and lateral ventricle volume correlated with CSF beta-amyloid 1-42. We can conclude that volumetric hippocampal measurements are the best predictors of AD conversion in subjects with MCI. (c) 2013 Elsevier Inc. All rights reserved. (Less)
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@article{3036200e-75db-418b-bade-dbfc954ba184,
  abstract     = {Our aim was to compare the predictive accuracy of 4 different medial temporal lobe measurements for Alzheimer's disease (AD) in subjects with mild cognitive impairment (MCI). Manual hippocampal measurement, automated atlas-based hippocampal measurement, a visual rating scale (MTA-score), and lateral ventricle measurement were compared. Predictive accuracy for AD 2 years after baseline was assessed by receiver operating characteristics analyses with area under the curve as outcome. Annual cognitive decline was assessed by slope analyses up to 5 years after baseline. Correlations with biomarkers in cerebrospinal fluid (CSF) were investigated. Subjects with MCI were selected from the Development of Screening Guidelines and Clinical Criteria for Predementia AD (DESCRIPA) multicenter study (n = 156) and the single-center VU medical center (n = 172). At follow-up, area under the curve was highest for automated atlas-based hippocampal measurement (0.71) and manual hippocampal measurement (0.71), and lower for MTA-score (0.65) and lateral ventricle (0.60). Slope analysis yielded similar results. Hippocampal measurements correlated with CSF total tau and phosphorylated tau, not with beta-amyloid 1-42. MTA-score and lateral ventricle volume correlated with CSF beta-amyloid 1-42. We can conclude that volumetric hippocampal measurements are the best predictors of AD conversion in subjects with MCI. (c) 2013 Elsevier Inc. All rights reserved.},
  author       = {Clerx, Lies and van Rossum, Ineke A. and Burns, Leah and Knol, Dirk L. and Scheltens, Philip and Verhey, Frans and Aalten, Pauline and Lapuerta, Pablo and van de Pol, Laura and van Schijndel, Ronald and de Jong, Remko and Barkhof, Frederik and Wolz, Robin and Rueckert, Daniel and Bocchetta, Martina and Tsolaki, Magdalini and Nobili, Flavio and Wahlund, Lars-Olaf and Minthon, Lennart and Froelich, Lutz and Hampel, Harald and Soininen, Hilkka and Visser, Pieter Jelle},
  issn         = {1558-1497},
  keyword      = {Alzheimer's disease,Mild cognitive impairment,Dementia,Magnetic,resonance imaging,Medial temporal lobe atrophy,Cerebrospinal fluid,(CSF),A beta 1-42,Tau},
  language     = {eng},
  number       = {8},
  pages        = {2003--2013},
  publisher    = {Elsevier},
  series       = {Neurobiology of Aging},
  title        = {Measurements of medial temporal lobe atrophy for prediction of Alzheimer's disease in subjects with mild cognitive impairment},
  url          = {http://dx.doi.org/10.1016/j.neurobiolaging.2013.02.002},
  volume       = {34},
  year         = {2013},
}