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The SELMA Study: A Birth Cohort Study in Sweden Following More Than 2000 Mother-Child Pairs.

Bornehag, Carl-Gustaf; Moniruzzaman, Syed; Larsson, Malin; Lindström, Cecilia Boman; Hasselgren, Mikael; Bodin, Anna; von Kobyletzkic, Laura B; Carlstedt, Fredrik; Lundin, Fredrik and Nånberg, Eewa, et al. (2012) In Paediatric and Perinatal Epidemiology 26(5). p.456-467
Abstract
Background:

This paper describes the background, aim and study design for the Swedish SELMA study that aimed to investigate the importance of early life exposure during pregnancy and infancy to environmental factors with a major focus on endocrine disrupting chemicals for multiple chronic diseases/disorders in offspring.



Methods:

The cohort was established by recruiting women in the 10th week of pregnancy. Blood and urine from the pregnant women and the child and air and dust from home environment from pregnancy and infancy period have been collected. Questionnaires were used to collect information on life styles, socio-economic status, living conditions, diet and medical history.

... (More)
Background:

This paper describes the background, aim and study design for the Swedish SELMA study that aimed to investigate the importance of early life exposure during pregnancy and infancy to environmental factors with a major focus on endocrine disrupting chemicals for multiple chronic diseases/disorders in offspring.



Methods:

The cohort was established by recruiting women in the 10th week of pregnancy. Blood and urine from the pregnant women and the child and air and dust from home environment from pregnancy and infancy period have been collected. Questionnaires were used to collect information on life styles, socio-economic status, living conditions, diet and medical history.



Results:

Of the 8394 reported pregnant women, 6658 were invited to participate in the study. Among the invited women, 2582 (39%) agreed to participate. Of the 4076 (61%) non-participants, 2091 women were invited to a non-respondent questionnaire in order to examine possible selection bias. We found a self-selection bias in the established cohort when compared with the non-participant group, e.g. participating families did smoke less (14% vs. 19%), had more frequent asthma and allergy symptoms in the family (58% vs. 38%), as well as higher education among the mothers (51% vs. 36%) and more often lived in single-family houses (67% vs. 60%).



Conclusions:

These findings indicate that the participating families do not fully represent the study population and thus, the exposure in this population. However, there is no obvious reason that this selection bias will have an impact on identification of environmental risk factors. (Less)
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type
Contribution to journal
publication status
published
subject
in
Paediatric and Perinatal Epidemiology
volume
26
issue
5
pages
456 - 467
publisher
Wiley-Blackwell
external identifiers
  • wos:000307392200009
  • pmid:22882790
  • scopus:84864859506
ISSN
0269-5022
DOI
10.1111/j.1365-3016.2012.01314.x
language
English
LU publication?
yes
id
dd616a3f-05f4-4a3d-97a3-07bbeea952ab (old id 3047591)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/22882790?dopt=Abstract
date added to LUP
2012-09-05 19:21:30
date last changed
2017-06-04 04:33:51
@article{dd616a3f-05f4-4a3d-97a3-07bbeea952ab,
  abstract     = {Background: <br/><br>
This paper describes the background, aim and study design for the Swedish SELMA study that aimed to investigate the importance of early life exposure during pregnancy and infancy to environmental factors with a major focus on endocrine disrupting chemicals for multiple chronic diseases/disorders in offspring. <br/><br>
<br/><br>
Methods: <br/><br>
The cohort was established by recruiting women in the 10th week of pregnancy. Blood and urine from the pregnant women and the child and air and dust from home environment from pregnancy and infancy period have been collected. Questionnaires were used to collect information on life styles, socio-economic status, living conditions, diet and medical history. <br/><br>
<br/><br>
Results: <br/><br>
Of the 8394 reported pregnant women, 6658 were invited to participate in the study. Among the invited women, 2582 (39%) agreed to participate. Of the 4076 (61%) non-participants, 2091 women were invited to a non-respondent questionnaire in order to examine possible selection bias. We found a self-selection bias in the established cohort when compared with the non-participant group, e.g. participating families did smoke less (14% vs. 19%), had more frequent asthma and allergy symptoms in the family (58% vs. 38%), as well as higher education among the mothers (51% vs. 36%) and more often lived in single-family houses (67% vs. 60%). <br/><br>
<br/><br>
Conclusions: <br/><br>
These findings indicate that the participating families do not fully represent the study population and thus, the exposure in this population. However, there is no obvious reason that this selection bias will have an impact on identification of environmental risk factors.},
  author       = {Bornehag, Carl-Gustaf and Moniruzzaman, Syed and Larsson, Malin and Lindström, Cecilia Boman and Hasselgren, Mikael and Bodin, Anna and von Kobyletzkic, Laura B and Carlstedt, Fredrik and Lundin, Fredrik and Nånberg, Eewa and Jönsson, Bo A and Sigsgaard, Torben and Janson, Staffan},
  issn         = {0269-5022},
  language     = {eng},
  number       = {5},
  pages        = {456--467},
  publisher    = {Wiley-Blackwell},
  series       = {Paediatric and Perinatal Epidemiology},
  title        = {The SELMA Study: A Birth Cohort Study in Sweden Following More Than 2000 Mother-Child Pairs.},
  url          = {http://dx.doi.org/10.1111/j.1365-3016.2012.01314.x},
  volume       = {26},
  year         = {2012},
}