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Asthma in Swedish children conceived by in vitro fertilisation.

Källén, Bengt LU ; Finnström, Orvar; Nygren, Karl-Gösta and Otterblad Olausson, Petra (2012) In Archives of disease in childhood
Abstract
OBJECTIVES:

To investigate a proposed association between in vitro fertilisation (IVF) and child asthma.



DESIGN:

The risk for asthma after IVF was estimated as ORs using Mantel-Haenszel analysis.



SETTING:

The Swedish Medical Birth Register.



PATIENTS:

Of the 2 628 728 children born in 1982-2007 and surviving the perinatal period, 31 918 were conceived by IVF. Presence of asthma was defined as at least five prescriptions of antiasthmatic drugs during the period 1 July 2005-31 December 2009 according to the Swedish Prescribed Drug Register (115 767 children, 2323 of whom were born after IVF).



RESULTS:

A... (More)
OBJECTIVES:

To investigate a proposed association between in vitro fertilisation (IVF) and child asthma.



DESIGN:

The risk for asthma after IVF was estimated as ORs using Mantel-Haenszel analysis.



SETTING:

The Swedish Medical Birth Register.



PATIENTS:

Of the 2 628 728 children born in 1982-2007 and surviving the perinatal period, 31 918 were conceived by IVF. Presence of asthma was defined as at least five prescriptions of antiasthmatic drugs during the period 1 July 2005-31 December 2009 according to the Swedish Prescribed Drug Register (115 767 children, 2323 of whom were born after IVF).



RESULTS:

A significantly increased risk for asthma, albeit small, was found in children conceived by IVF (aOR 1.28, 95% CI 1.23 to 1.34), increasing the absolute risk from 4.4% to 5.6%. The risk increase for asthma was the same in boys and girls, in singletons and twins, and after caesarean section and vaginal delivery. The risk was higher for preterm than term singletons. For children with a low Apgar score, respiratory diagnoses, mechanical ventilation, continuous positive airway pressure or neonatal sepsis, the effect of IVF on asthma risk was low and statistically non-significant. Adjustment for length of involuntary childlessness eliminated the effect, and removal of infants whose mothers had used antiasthmatics in early pregnancy reduced the risk.



CONCLUSIONS:

This study verifies an association between IVF and asthma in children. This can be partly explained by neonatal morbidity and by maternal asthma acting as mediators, but the main risk factor is parental subfertility. The mechanism for this is unclear. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Archives of disease in childhood
publisher
BMJ Publishing Group
external identifiers
  • wos:000313743400003
  • pmid:22875904
  • scopus:84872674933
ISSN
1468-2044
DOI
10.1136/archdischild-2012-301822
language
English
LU publication?
yes
id
e893e494-9ff5-4228-b408-4abe56b99bd9 (old id 3047687)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/22875904?dopt=Abstract
date added to LUP
2012-09-05 09:53:28
date last changed
2017-09-10 04:49:57
@article{e893e494-9ff5-4228-b408-4abe56b99bd9,
  abstract     = {OBJECTIVES: <br/><br>
To investigate a proposed association between in vitro fertilisation (IVF) and child asthma. <br/><br>
<br/><br>
DESIGN: <br/><br>
The risk for asthma after IVF was estimated as ORs using Mantel-Haenszel analysis. <br/><br>
<br/><br>
SETTING: <br/><br>
The Swedish Medical Birth Register. <br/><br>
<br/><br>
PATIENTS: <br/><br>
Of the 2 628 728 children born in 1982-2007 and surviving the perinatal period, 31 918 were conceived by IVF. Presence of asthma was defined as at least five prescriptions of antiasthmatic drugs during the period 1 July 2005-31 December 2009 according to the Swedish Prescribed Drug Register (115 767 children, 2323 of whom were born after IVF). <br/><br>
<br/><br>
RESULTS: <br/><br>
A significantly increased risk for asthma, albeit small, was found in children conceived by IVF (aOR 1.28, 95% CI 1.23 to 1.34), increasing the absolute risk from 4.4% to 5.6%. The risk increase for asthma was the same in boys and girls, in singletons and twins, and after caesarean section and vaginal delivery. The risk was higher for preterm than term singletons. For children with a low Apgar score, respiratory diagnoses, mechanical ventilation, continuous positive airway pressure or neonatal sepsis, the effect of IVF on asthma risk was low and statistically non-significant. Adjustment for length of involuntary childlessness eliminated the effect, and removal of infants whose mothers had used antiasthmatics in early pregnancy reduced the risk. <br/><br>
<br/><br>
CONCLUSIONS: <br/><br>
This study verifies an association between IVF and asthma in children. This can be partly explained by neonatal morbidity and by maternal asthma acting as mediators, but the main risk factor is parental subfertility. The mechanism for this is unclear.},
  author       = {Källén, Bengt and Finnström, Orvar and Nygren, Karl-Gösta and Otterblad Olausson, Petra},
  issn         = {1468-2044},
  language     = {eng},
  month        = {08},
  publisher    = {BMJ Publishing Group},
  series       = {Archives of disease in childhood},
  title        = {Asthma in Swedish children conceived by in vitro fertilisation.},
  url          = {http://dx.doi.org/10.1136/archdischild-2012-301822},
  year         = {2012},
}