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Lung Function as a Risk Factor for Subarachnoid Hemorrhage: A Prospective Cohort Study.

Söderholm, Martin LU ; Zia, Elisabet LU ; Hedblad, Bo LU and Engström, Gunnar LU (2012) In Stroke: a journal of cerebral circulation 43(10). p.2598-2598
Abstract
BACKGROUND AND PURPOSE:

The etiology of subarachnoid hemorrhage (SAH) is poorly understood. Reduced lung function, expressed as low forced expiratory volume in 1 second (FEV(1)) and low forced vital capacity (FVC), is a predictor of cardiovascular disease, but whether reduced lung function is a risk factor for SAH is not known. The association between lung function and incidence of SAH was investigated in a prospective cohort study.



METHODS: Between 1974 and 1992, 20 534 men and 7237 women (mean age, 44 years) were examined in a health screening program including spirometry. The incidence of SAH was studied during a mean follow-up of 26 years in relation to age- and height-standardized FEV(1), FVC, and... (More)
BACKGROUND AND PURPOSE:

The etiology of subarachnoid hemorrhage (SAH) is poorly understood. Reduced lung function, expressed as low forced expiratory volume in 1 second (FEV(1)) and low forced vital capacity (FVC), is a predictor of cardiovascular disease, but whether reduced lung function is a risk factor for SAH is not known. The association between lung function and incidence of SAH was investigated in a prospective cohort study.



METHODS: Between 1974 and 1992, 20 534 men and 7237 women (mean age, 44 years) were examined in a health screening program including spirometry. The incidence of SAH was studied during a mean follow-up of 26 years in relation to age- and height-standardized FEV(1), FVC, and FEV(1)/FVC.



RESULTS:

One hundred forty-five subjects had a SAH (18.3 per 100 000 person-years in men and 26.5 per 100 000 person-years in women). The hazard ratio for SAH in the lowest compared to the highest quartile of FEV(1) and FEV(1)/FVC was 2.24 (95% CI, 1.32-3.81; P for trend=0.014) and 1.92 (95% CI, 1.14-3.23; P for trend=0.003), respectively, after adjustment for several confounding factors including smoking and hypertension. The results persisted when analysis was restricted to nonsmokers. FVC showed no significant association with incidence of SAH.



CONCLUSIONS:

Baseline lung function, expressed as low FEV(1) or FEV(1)/FVC, is a risk factor for SAH, independently of smoking. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
prospective study, forced vital capacity, epidemiology, forced expiratory volume, subarachnoid hemorrhage, spirometry
in
Stroke: a journal of cerebral circulation
volume
43
issue
10
pages
2598 - 2598
publisher
American Heart Association
external identifiers
  • wos:000309258900021
  • pmid:22871680
  • scopus:84866744014
ISSN
1524-4628
DOI
10.1161/STROKEAHA.112.658427
language
English
LU publication?
yes
id
77ad3de7-cdb0-46ba-ba08-7d0ca7aeb3ba (old id 3047718)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/22871680?dopt=Abstract
date added to LUP
2012-09-04 21:31:31
date last changed
2017-03-12 03:51:17
@article{77ad3de7-cdb0-46ba-ba08-7d0ca7aeb3ba,
  abstract     = {BACKGROUND AND PURPOSE: <br/><br>
The etiology of subarachnoid hemorrhage (SAH) is poorly understood. Reduced lung function, expressed as low forced expiratory volume in 1 second (FEV(1)) and low forced vital capacity (FVC), is a predictor of cardiovascular disease, but whether reduced lung function is a risk factor for SAH is not known. The association between lung function and incidence of SAH was investigated in a prospective cohort study. <br/><br>
<br/><br>
METHODS: Between 1974 and 1992, 20 534 men and 7237 women (mean age, 44 years) were examined in a health screening program including spirometry. The incidence of SAH was studied during a mean follow-up of 26 years in relation to age- and height-standardized FEV(1), FVC, and FEV(1)/FVC. <br/><br>
<br/><br>
RESULTS: <br/><br>
One hundred forty-five subjects had a SAH (18.3 per 100 000 person-years in men and 26.5 per 100 000 person-years in women). The hazard ratio for SAH in the lowest compared to the highest quartile of FEV(1) and FEV(1)/FVC was 2.24 (95% CI, 1.32-3.81; P for trend=0.014) and 1.92 (95% CI, 1.14-3.23; P for trend=0.003), respectively, after adjustment for several confounding factors including smoking and hypertension. The results persisted when analysis was restricted to nonsmokers. FVC showed no significant association with incidence of SAH. <br/><br>
<br/><br>
CONCLUSIONS: <br/><br>
Baseline lung function, expressed as low FEV(1) or FEV(1)/FVC, is a risk factor for SAH, independently of smoking.},
  author       = {Söderholm, Martin and Zia, Elisabet and Hedblad, Bo and Engström, Gunnar},
  issn         = {1524-4628},
  keyword      = {prospective study,forced vital capacity,epidemiology,forced expiratory volume,subarachnoid hemorrhage,spirometry},
  language     = {eng},
  number       = {10},
  pages        = {2598--2598},
  publisher    = {American Heart Association},
  series       = { Stroke: a journal of cerebral circulation},
  title        = {Lung Function as a Risk Factor for Subarachnoid Hemorrhage: A Prospective Cohort Study.},
  url          = {http://dx.doi.org/10.1161/STROKEAHA.112.658427},
  volume       = {43},
  year         = {2012},
}