Simulated Mid-ranging Control of Propofol and Remifentanil using EEG-measured Hypnotic Depth of Anesthesia
(2012) 51st IEEE Conference on Decision and Control, 2012 p.356-361- Abstract
- This paper suggests an extension of an existing, clinically evaluated, closed-loop drug delivery system for hypnotic depth control using propofol. The extension introduces closed-loop administration of the analgesic drug remifentanil, thus forming a multiple input–single output (MISO) control system. Remifentanil acts and is metabolized at a significantly faster time scale than propofol. Direct control of analgesia is hindered by the current absence of a reliable real-time nociception monitor. However, several hypnotic depth monitors respond to nociception. Sudden changes in the measured hypnotic depth are frequently caused by changes in noxious stimulation. The novelty of this work lies in increasing the disturbance rejection bandwidth of... (More)
- This paper suggests an extension of an existing, clinically evaluated, closed-loop drug delivery system for hypnotic depth control using propofol. The extension introduces closed-loop administration of the analgesic drug remifentanil, thus forming a multiple input–single output (MISO) control system. Remifentanil acts and is metabolized at a significantly faster time scale than propofol. Direct control of analgesia is hindered by the current absence of a reliable real-time nociception monitor. However, several hypnotic depth monitors respond to nociception. Sudden changes in the measured hypnotic depth are frequently caused by changes in noxious stimulation. The novelty of this work lies in increasing the disturbance rejection bandwidth of the control system for hypnotic depth by directing the high frequency content of its control error to a remifentanil controller. Such a mid-ranging control system was implemented and tuned based on 23 patient models obtained from a previous clinical study and its performance is demonstrated through a simulation study. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/3048310
- author
- Soltesz, Kristian LU ; Dumont, Guy A. ; van Heusden, Klaske ; Hägglund, Tore LU and Ansermino, J. Mark
- organization
- publishing date
- 2012
- type
- Chapter in Book/Report/Conference proceeding
- publication status
- published
- subject
- keywords
- Medical control systems, Drug delivery, Control system synthesis, Medical simulation
- host publication
- 51st IEEE Conference on Decision and Control
- pages
- 356 - 361
- publisher
- IEEE - Institute of Electrical and Electronics Engineers Inc.
- conference name
- 51st IEEE Conference on Decision and Control, 2012
- conference location
- Maui, Hawaii, United States
- conference dates
- 2012-12-10 - 2012-12-13
- external identifiers
-
- wos:000327200400059
- scopus:84874244604
- ISSN
- 0191-2216
- ISBN
- 978-1-4673-2064-1
- DOI
- 10.1109/CDC.2012.6426858
- project
- Anesthesia in Closed Loop
- LCCC
- language
- English
- LU publication?
- yes
- id
- 0b71d0f9-cc49-49ff-bc1e-b63d037c444e (old id 3048310)
- date added to LUP
- 2016-04-01 14:18:19
- date last changed
- 2024-03-27 15:18:45
@inproceedings{0b71d0f9-cc49-49ff-bc1e-b63d037c444e, abstract = {{This paper suggests an extension of an existing, clinically evaluated, closed-loop drug delivery system for hypnotic depth control using propofol. The extension introduces closed-loop administration of the analgesic drug remifentanil, thus forming a multiple input–single output (MISO) control system. Remifentanil acts and is metabolized at a significantly faster time scale than propofol. Direct control of analgesia is hindered by the current absence of a reliable real-time nociception monitor. However, several hypnotic depth monitors respond to nociception. Sudden changes in the measured hypnotic depth are frequently caused by changes in noxious stimulation. The novelty of this work lies in increasing the disturbance rejection bandwidth of the control system for hypnotic depth by directing the high frequency content of its control error to a remifentanil controller. Such a mid-ranging control system was implemented and tuned based on 23 patient models obtained from a previous clinical study and its performance is demonstrated through a simulation study.}}, author = {{Soltesz, Kristian and Dumont, Guy A. and van Heusden, Klaske and Hägglund, Tore and Ansermino, J. Mark}}, booktitle = {{51st IEEE Conference on Decision and Control}}, isbn = {{978-1-4673-2064-1}}, issn = {{0191-2216}}, keywords = {{Medical control systems; Drug delivery; Control system synthesis; Medical simulation}}, language = {{eng}}, pages = {{356--361}}, publisher = {{IEEE - Institute of Electrical and Electronics Engineers Inc.}}, title = {{Simulated Mid-ranging Control of Propofol and Remifentanil using EEG-measured Hypnotic Depth of Anesthesia}}, url = {{https://lup.lub.lu.se/search/files/33238392/soltesz12c.pdf}}, doi = {{10.1109/CDC.2012.6426858}}, year = {{2012}}, }