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Simulated Mid-ranging Control of Propofol and Remifentanil using EEG-measured Hypnotic Depth of Anesthesia

Soltesz, Kristian LU ; Dumont, Guy A.; van Heusden, Klaske; Hägglund, Tore LU and Ansermino, J. Mark (2012) 51st IEEE Conference on Decision and Control, 2012 In 51st IEEE Conference on Decision and Control p.356-361
Abstract
This paper suggests an extension of an existing, clinically evaluated, closed-loop drug delivery system for hypnotic depth control using propofol. The extension introduces closed-loop administration of the analgesic drug remifentanil, thus forming a multiple input–single output (MISO) control system. Remifentanil acts and is metabolized at a significantly faster time scale than propofol. Direct control of analgesia is hindered by the current absence of a reliable real-time nociception monitor. However, several hypnotic depth monitors respond to nociception. Sudden changes in the measured hypnotic depth are frequently caused by changes in noxious stimulation. The novelty of this work lies in increasing the disturbance rejection bandwidth of... (More)
This paper suggests an extension of an existing, clinically evaluated, closed-loop drug delivery system for hypnotic depth control using propofol. The extension introduces closed-loop administration of the analgesic drug remifentanil, thus forming a multiple input–single output (MISO) control system. Remifentanil acts and is metabolized at a significantly faster time scale than propofol. Direct control of analgesia is hindered by the current absence of a reliable real-time nociception monitor. However, several hypnotic depth monitors respond to nociception. Sudden changes in the measured hypnotic depth are frequently caused by changes in noxious stimulation. The novelty of this work lies in increasing the disturbance rejection bandwidth of the control system for hypnotic depth by directing the high frequency content of its control error to a remifentanil controller. Such a mid-ranging control system was implemented and tuned based on 23 patient models obtained from a previous clinical study and its performance is demonstrated through a simulation study. (Less)
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author
organization
publishing date
type
Chapter in Book/Report/Conference proceeding
publication status
published
subject
keywords
Medical control systems, Drug delivery, Control system synthesis, Medical simulation
in
51st IEEE Conference on Decision and Control
pages
356 - 361
publisher
IEEE--Institute of Electrical and Electronics Engineers Inc.
conference name
51st IEEE Conference on Decision and Control, 2012
external identifiers
  • wos:000327200400059
  • scopus:84874244604
ISSN
0191-2216
ISBN
978-1-4673-2064-1
DOI
10.1109/CDC.2012.6426858
project
LCCC
language
English
LU publication?
yes
id
0b71d0f9-cc49-49ff-bc1e-b63d037c444e (old id 3048310)
date added to LUP
2012-09-05 09:45:30
date last changed
2017-10-16 08:42:26
@inproceedings{0b71d0f9-cc49-49ff-bc1e-b63d037c444e,
  abstract     = {This paper suggests an extension of an existing, clinically evaluated, closed-loop drug delivery system for hypnotic depth control using propofol. The extension introduces closed-loop administration of the analgesic drug remifentanil, thus forming a multiple input–single output (MISO) control system. Remifentanil acts and is metabolized at a significantly faster time scale than propofol. Direct control of analgesia is hindered by the current absence of a reliable real-time nociception monitor. However, several hypnotic depth monitors respond to nociception. Sudden changes in the measured hypnotic depth are frequently caused by changes in noxious stimulation. The novelty of this work lies in increasing the disturbance rejection bandwidth of the control system for hypnotic depth by directing the high frequency content of its control error to a remifentanil controller. Such a mid-ranging control system was implemented and tuned based on 23 patient models obtained from a previous clinical study and its performance is demonstrated through a simulation study.},
  author       = {Soltesz, Kristian and Dumont, Guy A. and van Heusden, Klaske and Hägglund, Tore and Ansermino, J. Mark},
  booktitle    = {51st IEEE Conference on Decision and Control},
  isbn         = {978-1-4673-2064-1},
  issn         = {0191-2216},
  keyword      = {Medical control systems,Drug delivery,Control system synthesis,Medical simulation},
  language     = {eng},
  pages        = {356--361},
  publisher    = {IEEE--Institute of Electrical and Electronics Engineers Inc.},
  title        = {Simulated Mid-ranging Control of Propofol and Remifentanil using EEG-measured Hypnotic Depth of Anesthesia},
  url          = {http://dx.doi.org/10.1109/CDC.2012.6426858},
  year         = {2012},
}