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Selected contribution: role of spleen emptying in prolonging apneas in humans

Schagatay, Erica; Andersson, Johan P.; Hallén, Magnus LU and Pålsson, Birger LU (2001) In Journal of Applied Physiology 90(4). p.9-1623
Abstract
This study addressed the interaction between short-term adaptation to apneas with face immersion and erythrocyte release from the spleen. Twenty healthy volunteers, including ten splenectomized subjects, participated. After prone rest, they performed five maximal-duration apneas with face immersion in 10 degrees C water, with 2-min intervals. Cardiorespiratory parameters and venous blood samples were collected. In subjects with spleens, hematocrit and hemoglobin concentration increased by 6.4% and 3.3%, respectively, over the serial apneas and returned to baseline 10 min after the series. A delay of the physiological breaking point of apnea, by 30.5% (17 s), was seen only in this group. These parameters did not change in the splenectomized... (More)
This study addressed the interaction between short-term adaptation to apneas with face immersion and erythrocyte release from the spleen. Twenty healthy volunteers, including ten splenectomized subjects, participated. After prone rest, they performed five maximal-duration apneas with face immersion in 10 degrees C water, with 2-min intervals. Cardiorespiratory parameters and venous blood samples were collected. In subjects with spleens, hematocrit and hemoglobin concentration increased by 6.4% and 3.3%, respectively, over the serial apneas and returned to baseline 10 min after the series. A delay of the physiological breaking point of apnea, by 30.5% (17 s), was seen only in this group. These parameters did not change in the splenectomized group. Plasma protein concentration, preapneic alveolar PCO2, inspired lung volume, and diving bradycardia remained unchanged throughout the series in both groups. Serial apneas thus triggered the hematological changes that have been previously observed after long apneic diving shifts; they were rapidly reversed and did not occur in splenectomized subjects. This suggests that splenic contraction occurs in humans as a part of the diving response and may prolong repeated apneas. (Less)
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author
organization
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type
Contribution to journal
publication status
published
subject
keywords
Adult, Apnea, Blood Pressure/physiology, Blood Proteins/metabolism, Carbon Dioxide/blood, Face, Female, Heart Rate/physiology, Hematocrit, Hemoglobins/metabolism, Humans, Immersion, Lung Volume Measurements, Male, Regional Blood Flow/physiology, Spleen/ physiology, Splenectomy
in
Journal of Applied Physiology
volume
90
issue
4
pages
9 - 1623
publisher
American Physiological Society
external identifiers
  • scopus:0035107586
ISSN
1522-1601
language
English
LU publication?
yes
id
d809e502-1468-41c1-9f6b-61004b896e1c (old id 3052317)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/11247970
http://jap.physiology.org/content/90/4/1623.long
date added to LUP
2013-05-07 14:26:39
date last changed
2018-01-07 10:01:25
@article{d809e502-1468-41c1-9f6b-61004b896e1c,
  abstract     = {This study addressed the interaction between short-term adaptation to apneas with face immersion and erythrocyte release from the spleen. Twenty healthy volunteers, including ten splenectomized subjects, participated. After prone rest, they performed five maximal-duration apneas with face immersion in 10 degrees C water, with 2-min intervals. Cardiorespiratory parameters and venous blood samples were collected. In subjects with spleens, hematocrit and hemoglobin concentration increased by 6.4% and 3.3%, respectively, over the serial apneas and returned to baseline 10 min after the series. A delay of the physiological breaking point of apnea, by 30.5% (17 s), was seen only in this group. These parameters did not change in the splenectomized group. Plasma protein concentration, preapneic alveolar PCO2, inspired lung volume, and diving bradycardia remained unchanged throughout the series in both groups. Serial apneas thus triggered the hematological changes that have been previously observed after long apneic diving shifts; they were rapidly reversed and did not occur in splenectomized subjects. This suggests that splenic contraction occurs in humans as a part of the diving response and may prolong repeated apneas.},
  author       = {Schagatay, Erica and Andersson, Johan P. and Hallén, Magnus and Pålsson, Birger},
  issn         = {1522-1601},
  keyword      = {Adult,Apnea,Blood Pressure/physiology,Blood Proteins/metabolism,Carbon Dioxide/blood,Face,Female,Heart Rate/physiology,Hematocrit,Hemoglobins/metabolism,Humans,Immersion,Lung Volume Measurements,Male,Regional Blood Flow/physiology,Spleen/ physiology,Splenectomy},
  language     = {eng},
  number       = {4},
  pages        = {9--1623},
  publisher    = {American Physiological Society},
  series       = {Journal of Applied Physiology},
  title        = {Selected contribution: role of spleen emptying in prolonging apneas in humans},
  volume       = {90},
  year         = {2001},
}