MIRD Pamphlet No. 23: Quantitative SPECT for Patient-Specific 3-Dimensional Dosimetry in Internal Radionuclide Therapy
(2012) In Journal of Nuclear Medicine 53(8). p.1310-1325- Abstract
- In internal radionuclide therapy, a growing interest in voxel-level estimates of tissue-absorbed dose has been driven by the desire to report radiobiologic quantities that account for the biologic consequences of both spatial and temporal nonuniformities in these dose estimates. This report presents an overview of 3-dimensional SPECT methods and requirements for internal dosimetry at both regional and voxel levels. Combined SPECT/CT image-based methods are emphasized, because the CT-derived anatomic information allows one to address multiple technical factors that affect SPECT quantification while facilitating the patient-specific voxel-level dosimetry calculation itself. SPECT imaging and reconstruction techniques for quantification in... (More)
- In internal radionuclide therapy, a growing interest in voxel-level estimates of tissue-absorbed dose has been driven by the desire to report radiobiologic quantities that account for the biologic consequences of both spatial and temporal nonuniformities in these dose estimates. This report presents an overview of 3-dimensional SPECT methods and requirements for internal dosimetry at both regional and voxel levels. Combined SPECT/CT image-based methods are emphasized, because the CT-derived anatomic information allows one to address multiple technical factors that affect SPECT quantification while facilitating the patient-specific voxel-level dosimetry calculation itself. SPECT imaging and reconstruction techniques for quantification in radionuclide therapy are not necessarily the same as those designed to optimize diagnostic imaging quality. The current overview is intended as an introduction to an upcoming series of MIRD pamphlets with detailed radionuclide-specific recommendations intended to provide best-practice SPECT quantification-based guidance for radionuclide dosimetry. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/3053203
- author
- Dewaraja, Y. K. ; Frey, E. C. ; Sgouros, G. ; Brill, A. B. ; Roberson, P. ; Zanzonico, P. B. and Ljungberg, Michael LU
- organization
- publishing date
- 2012
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Journal of Nuclear Medicine
- volume
- 53
- issue
- 8
- pages
- 1310 - 1325
- publisher
- Society of Nuclear Medicine
- external identifiers
-
- wos:000307201300034
- scopus:84864751150
- pmid:22743252
- ISSN
- 0161-5505
- DOI
- 10.2967/jnumed.111.100123
- language
- English
- LU publication?
- yes
- additional info
- 8
- id
- a2367947-150b-495a-8e87-dbc9694100a6 (old id 3053203)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/22743252
- date added to LUP
- 2016-04-04 09:08:24
- date last changed
- 2022-03-31 01:04:33
@article{a2367947-150b-495a-8e87-dbc9694100a6, abstract = {{In internal radionuclide therapy, a growing interest in voxel-level estimates of tissue-absorbed dose has been driven by the desire to report radiobiologic quantities that account for the biologic consequences of both spatial and temporal nonuniformities in these dose estimates. This report presents an overview of 3-dimensional SPECT methods and requirements for internal dosimetry at both regional and voxel levels. Combined SPECT/CT image-based methods are emphasized, because the CT-derived anatomic information allows one to address multiple technical factors that affect SPECT quantification while facilitating the patient-specific voxel-level dosimetry calculation itself. SPECT imaging and reconstruction techniques for quantification in radionuclide therapy are not necessarily the same as those designed to optimize diagnostic imaging quality. The current overview is intended as an introduction to an upcoming series of MIRD pamphlets with detailed radionuclide-specific recommendations intended to provide best-practice SPECT quantification-based guidance for radionuclide dosimetry.}}, author = {{Dewaraja, Y. K. and Frey, E. C. and Sgouros, G. and Brill, A. B. and Roberson, P. and Zanzonico, P. B. and Ljungberg, Michael}}, issn = {{0161-5505}}, language = {{eng}}, number = {{8}}, pages = {{1310--1325}}, publisher = {{Society of Nuclear Medicine}}, series = {{Journal of Nuclear Medicine}}, title = {{MIRD Pamphlet No. 23: Quantitative SPECT for Patient-Specific 3-Dimensional Dosimetry in Internal Radionuclide Therapy}}, url = {{http://dx.doi.org/10.2967/jnumed.111.100123}}, doi = {{10.2967/jnumed.111.100123}}, volume = {{53}}, year = {{2012}}, }