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Single-fiber diffuse optical time-of-flight spectroscopy

Alerstam, Erik LU ; Svensson, Tomas LU ; Andersson-Engels, Stefan LU ; Spinelli, Lorenzo; Contini, Davide; Dalla Mora, Alberto; Tosi, Alberto; Zappa, Franco and Pifferi, Antonio (2012) In Optics Letters 37(14). p.2877-2879
Abstract
We demonstrate interstitial diffuse optical time-of-fight spectroscopy based on a single fiber for both light delivery and detection. Detector saturation due to the massive short-time reflection is avoided by ultrafast gating of a single photon avalanche diode. We show that the effects of scattering and absorption are separable and that absorption can be assessed independently of scattering. Measurements on calibrated liquid phantoms and subsequent Monte Carlo-based evaluation illustrate that absorption coefficients can be accurately assessed over a wide range of medically relevant optical properties. Our findings pave the way to simplified and less invasive interstitial in vivo spectroscopy. (C) 2012 Optical Society of America
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Optics Letters
volume
37
issue
14
pages
2877 - 2879
publisher
Optical Society of America
external identifiers
  • wos:000306709900036
  • scopus:84864339037
ISSN
0146-9592
DOI
10.1364/OL.37.002877
language
English
LU publication?
yes
id
83e6f46a-bafc-4add-a8a1-4af3e18f4e02 (old id 3059858)
date added to LUP
2012-09-26 14:56:00
date last changed
2017-04-23 03:55:56
@article{83e6f46a-bafc-4add-a8a1-4af3e18f4e02,
  abstract     = {We demonstrate interstitial diffuse optical time-of-fight spectroscopy based on a single fiber for both light delivery and detection. Detector saturation due to the massive short-time reflection is avoided by ultrafast gating of a single photon avalanche diode. We show that the effects of scattering and absorption are separable and that absorption can be assessed independently of scattering. Measurements on calibrated liquid phantoms and subsequent Monte Carlo-based evaluation illustrate that absorption coefficients can be accurately assessed over a wide range of medically relevant optical properties. Our findings pave the way to simplified and less invasive interstitial in vivo spectroscopy. (C) 2012 Optical Society of America},
  author       = {Alerstam, Erik and Svensson, Tomas and Andersson-Engels, Stefan and Spinelli, Lorenzo and Contini, Davide and Dalla Mora, Alberto and Tosi, Alberto and Zappa, Franco and Pifferi, Antonio},
  issn         = {0146-9592},
  language     = {eng},
  number       = {14},
  pages        = {2877--2879},
  publisher    = {Optical Society of America},
  series       = {Optics Letters},
  title        = {Single-fiber diffuse optical time-of-flight spectroscopy},
  url          = {http://dx.doi.org/10.1364/OL.37.002877},
  volume       = {37},
  year         = {2012},
}